Publications
Citation
Nierman, W., Eisen, J. A., Fraser, C. M.
Microbial genome sequencing 2000: new insights into physiology, evolution and expression analysis
Res Microbiol. 2000 Mar 01; 151(2): 79-84.
Abstract
The complete genome sequence has been reported for 24 microbial organisms. The genome organization and gene content of these organisms has revealed an incredible diversity. Nearly half of the open reading frames identified by these sequencing projects are for potential genes with no known biological function. Efforts to make evolutionary sense and biological sense of the gene content of these organisms have been initiated. The greatest future challenge of genomics will be to determine function for the unknown genes.