JCVI: Spectrum of Mitochondrial Genomic Variation and Associated Clinical Presentation of Prostate Cancer in South African Men.
 
 
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Citation

McCrow JP, Petersen DC, Louw M, Chan EK, Harmeyer K, Vecchiarelli S, Lyons RJ, Bornman MS, Hayes VM

Spectrum of Mitochondrial Genomic Variation and Associated Clinical Presentation of Prostate Cancer in South African Men.

The Prostate. 2016 Mar 01; 76: 349-58.

External Citation

Abstract

Prostate cancer incidence and mortality rates are significantly increased in African-American men, but limited studies have been performed within Sub-Saharan African populations. As mitochondria control energy metabolism and apoptosis we speculate that somatic mutations within mitochondrial genomes are candidate drivers of aggressive prostate carcinogenesis.