Peterson, S. N., Fraser, C. M.
The Complexity of Simplicity
Genome Biol. 2001 Feb 08; 2(2): COMMENT2002.
What is the minimum number of genes or functions necessary to support cellular life? The concept of a 'minimal genome' has become popular, but is it a useful concept, and if so, what might a minimal genome encode? We argue that the concept may be useful, even though the goal of defining a general minimal genome may never be attained.