JCVI: Toward an Ontological Treatment of Disease and Diagnosis.
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Scheuermann RH, Ceusters W, Smith B

Toward an Ontological Treatment of Disease and Diagnosis.

Summit on translational bioinformatics. 2009 May 01; 2009: 116-20.

External Citation


Many existing biomedical vocabulary standards rest on incomplete, inconsistent or confused accounts of basic terms pertaining to diseases, diagnoses, and clinical phenotypes. Here we outline what we believe to be a logically and biologically coherent framework for the representation of such entities and of the relations between them. We defend a view of disease as involving in every case some physical basis within the organism that bears a disposition toward the execution of pathological processes. We present our view in the form of a list of terms and definitions designed to provide a consistent starting point for the representation of both disease and diagnosis in information systems in the future.

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