Lawniczak, M. K., Emrich, S. J., Holloway, A. K., Regier, A. P., Olson, M., White, B., Redmond, S., Fulton, L., Appelbaum, E., Godfrey, J., Farmer, C., Chinwalla, A., Yang, S. P., Minx, P., Nelson, J., Kyung, K., Walenz, B. P., Garcia-Hernandez, E., Aguiar, M., Viswanathan, L. D., Rogers, Y. H., Strausberg, R. L., Saski, C. A., Lawson, D., Collins, F. H., Kafatos, F. C., Christophides, G. K., Clifton, S. W., Kirkness, E. F., Besansky, N. J.
Widespread Divergence Between Incipient Anopheles gambiae Species Revealed by Whole Genome Sequences
Science. 2010 Oct 22; 330(6003): 512-4.
The Afrotropical mosquito Anopheles gambiae sensu stricto, a major vector of malaria, is currently undergoing speciation into the M and S molecular forms. These forms have diverged in larval ecology and reproductive behavior through unknown genetic mechanisms, despite considerable levels of hybridization. Previous genome-wide scans using gene-based microarrays uncovered divergence between M and S that was largely confined to gene-poor pericentromeric regions, prompting a speciation-with-ongoing-gene-flow model that implicated only about 3% of the genome near centromeres in the speciation process. Here, based on the complete M and S genome sequences, we report widespread and heterogeneous genomic divergence inconsistent with appreciable levels of interform gene flow, suggesting a more advanced speciation process and greater challenges to identify genes critical to initiating that process.