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Human Microbiome Studies (HMS)

Overview

As a leading genomics research organization, the J. Craig Venter Institute has numerous projects and programs that are focused on this emerging research area to identify and characterize the human microbiome — the microbial populations that natively inhabit the human body — and to determine its role in health and disease. JCVI led the foray into this field with a seminal publication in 2006 and has since developed many active areas of research with various clinical sites. Here we outline these projects which investigate the relationship between human health and disease and how this correlates with changes in the human microbiome.  

Featured Highlights

A Metagenomics Approach to Understanding the Relationship...

Bacterial Vaginosis (BV), also called nonspecific vaginitis or Gardnerella-associated vaginitis, is a condition that is estimated to affect...

A Pilot Gut Microbiome study to evaluate TEDDY Infectious Agents

In this study, we propose to investigate the Prokaryotic species associated with the gut microbiome using whole genome shotgun metagenomic...

Algorithmically-Tuned Protein Families, Rule Base and...

We are developing computational tools to analyze the complexity of metagenomic sequencing data generated by the Human Microbiome Project.

Astronaut Microbiome

Our goal is to determine how the composition of the human microbiome changes during long-term space exploration and to evaluate its...

Asymptomatic Bacteriuria: Microbiome and Metaproteome

Clinical dogma is that healthy urine is sterile and the presence of bacteria with an inflammatory response is indicative of urinary tract...

Bacterial Translocation and Changes in the Intestinal Microbiome...

According to the Centers for Disease Control and Prevention, mortality associated with chronic liver disease ranks as the 12th most common...

Chronic Wound Microbiome

Chronic wound is a major public healthcare burden that costs approximately $25 billion per year and affects about 1% of the US population....

Colon Cancer Pilot Study

Colonic adenomatous polyps are common tumors occurring in ~50% of Western populations with ~10% risk of malignant progression.

Evaluation of the cutaneous microbiome in psoriasis

Psoriasis, a highly prevalent disease of humans of unknown cause, although it is considered to be a T cell — mediated autoimmune disease,...

Human Microbiome Project (HMP)

The NIH Human Microbiome Project (HMP) was initiated to help determine the core human microbiome, to understand the changes in the human...

Making a Quantum Leap in Plaque Research with Modern Sciences

Tooth decay (caries) remains a major health issue in the United States and worldwide with a prevalence of more than 50% in young children...

Molecular Hallmarks of Naturally Acquired Immunity to Malaria

Prospective studies of immune responses before, during, and after a given perturbation, whether by infection or vaccination, provide the...

Nasopharynx Microbiome and Vaccination in Children

The nasopharynx (NP) is home to many microorganisms that begin colonizing the body soon after birth. The collection of microbes, the...

PFAPA

Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis syndrome (PFAPA) is a periodic fever disorder of childhood classically...

Progression of Esophageal Cancer

The distal esophagus is an important anatomic locus where gastric acid reflux causes reflux esophagitis (RE), Barrett's esophagus (BE)...

Respiratory Microbiome Associated with Respiratory Syncytial...

As the single most important cause of serious lower respiratory tract disease in infants and young children in the United States and...

Revealing Roles of Uncultivated Species in the Oral Microbiome

Many human microbial infectious diseases including oral caries are polymicrobial in nature, and closely associated with ecological...

The Ferret Upper Respiratory Microbiome

Infection susceptibility and disease severity is regulated by a complex balance between the genotype of the pathogen, the genotype of the...

Type 1 Diabetes: Investigating the Gut Microbiome, Urinary...

Type 1 diabetes mellitus (T1D) is characterized by autoimmune destruction of the insulin producing - cells of pancreatic islets. It is...

Urethral Catheter-Associated Polybacterial Biofilm Formation and...

Biofilms are matrix-enclosed microbial assemblies adhering to non-biological and biological surfaces. They undergo dynamic...

Zoo in You Traveling Exhibition

The Oregon Museum of Science and Industry (OMSI), in partnership with the JCVI, is developing a 2,000 square foot bilingual (English and...