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Meta-CATS: Metadata-driven Comparative Analysis Tool for Sequences


What is it?

The metadata-driven comparative analysis tool for sequences (meta-CATS) rapidly identifies sequence variations that significantly correlate between groups of viruses with different attributes.

How do I use it?

  1. Go to the meta-CATS page in IRD or ViPR
  2. Specify the sequences that you want to include in the analysis
  3. Divide your sequences into groups based on: host species, year or place of isolation, virulence, tropism, etc.
  4. Verify the groupings
  5. Click “Run” 

What can you do?

  • Meta-CATS performs tandem chi-square tests to identify significant positions that vary according to the specified sequence groupings
  • The results are helpful in generating hypotheses that can be tested experimentally.





Pickett BE, Liu M, et al.
Metadata-driven Comparative Analysis Tool for Sequences (meta-CATS): an Automated Process for Identifying Significant Sequence Variations That Correlate With Virus Attributes.

Virology. 2013 Dec 01; 447: 45-51.[more]

Pickett BE, Greer DS, et al.
Virus Pathogen Database and Analysis Resource (ViPR): a Comprehensive Bioinformatics Database and Analysis Resource for the Coronavirus Research Community.

Viruses. 2012 Nov 01; 4: 3209-26.[more]

Pickett BE, Sadat EL, et al.
ViPR: an Open Bioinformatics Database and Analysis Resource for Virology Research.

Nucleic Acids Research. 2012 Jan 01; 40: D593-8.[more]


National Institute of Allergy and Infectious Disease (NIAID)

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