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The Microbial Protein Interaction Database

Interaction Evidences

prrB - prrA ( Mycobacterium tuberculosis )

Protein A	Protein B
P0A5Z8 Sensor-type histidine kinase prrB prrB Rv0902c, MT0925	P0A5Z6 Transcriptional regulatory protein prrA prrA Rv0903c, MT0926
CMR Search...	CMR Search...
GO MF: two-component sensor activity GO MF: ATP binding GO CC: integral to membrane GO CC: plasma membrane GO BP: peptidyl-histidine phosphorylation GO BP: two-component signal transduction system (p...	GO MF: DNA binding GO MF: two-component response regulator activity GO CC: cytoplasm GO BP: transcription GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...

List of evidences (45)

Experiments (1)

Method	DB Source	Type	Publication
enzymatic study		direct interaction	Nowak E et al. (2006)

Interologs (43)

MXAN_3451 (16%) - MXAN_3450 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 33% E-Value: 1.69e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (16%) - phoP2 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 33% E-Value: 1.63e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

creC (13%) - creB (31%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 21% Positives: 32% E-Value: 1.10e-14

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

MXAN_5211 (13%) - MXAN_3450 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 32% E-Value: 9.27e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (12%) - MXAN_3450 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 28% E-Value: 1.10e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr0533 (13%) - sll0649 (30%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 2.00e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_5211 (13%) - phoP2 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 8.97e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_4164 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 30% E-Value: 1.43e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4165 (13%) - MXAN_4164 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 30% E-Value: 6.43e-15

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

cpxA (11%) - cpxR (33%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 19% Positives: 28% E-Value: 9.59e-15

Method	DB Source	Type	Publication
unspecified method		physical association	Nakayama S et al. (2003)

kdpD (12%) - kdpE (30%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 19% Positives: 30% E-Value: 2.07e-17

Method	DB Source	Type	Publication
adenylate cyclase complementation		physical association	Luttmann D et al. (2009)
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)
enzymatic study		physical association	Heermann R et al. (2003)
protein kinase assay		physical association	Luttmann D et al. (2009)

MXAN_5211 (13%) - MXAN_1680 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 30% E-Value: 4.46e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (11%) - MXAN_3450 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 26% E-Value: 5.26e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (11%) - MXAN_1349 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 26% E-Value: 4.16e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (12%) - MXAN_5995 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 27% E-Value: 4.31e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (12%) - MXAN_4164 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 27% E-Value: 1.69e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (11%) - MXAN_5313 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 26% E-Value: 7.85e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (11%) - phoP1 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 26% E-Value: 3.41e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoQ (12%) - phoP (27%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 2.21e-15

Method	DB Source	Type	Publication
far western blotting		physical association	Chamnongpol S et al. (2000)
surface plasmon resonance		physical association	Castelli ME et al. (2003)

basS (12%) - basR (28%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 4.61e-13

Method	DB Source	Type	Publication
coimmunoprecipitation		physical association	Kato A et al. (2004)

MXAN_1350 (12%) - MXAN_1680 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 27% E-Value: 1.21e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (11%) - phoP3 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 26% E-Value: 1.87e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (11%) - phoP2 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 26% E-Value: 5.09e-16

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoQ (11%) - phoP (26%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 17% Positives: 32% E-Value: 2.89e-15

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

MXAN_3451 (16%) - MXAN_2606 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 23% E-Value: 5.82e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

rstB (11%) - rstA (23%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 1.81e-09

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

MXAN_5211 (13%) - MXAN_2606 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 3.19e-10

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 1.75e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (12%) - MXAN_2606 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 3.77e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1350 (12%) - MXAN_2606 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 8.69e-12

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_0460 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 2.89e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (12%) - MXAN_0460 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 7.87e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (11%) - MXAN_2606 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 18% E-Value: 1.81e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (11%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 18% E-Value: 9.94e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 3.09e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (12%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 8.40e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (12%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 2.07e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (12%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 3.65e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 9.62e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (12%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 18% E-Value: 2.62e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (12%) - cheB1 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 5.27e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (11%) - MXAN_0460 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 1.64e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (11%) - MXAN_7143 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.64e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Domain-Domain Interactions (1)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID	predicted interaction	Response_reg	HisKA

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