The Microbial Protein Interaction Database

physical association

Hallez R et al. (2007)

slr2100 (32%) - slr2098 (17%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 24% Positives: 42% E-Value: 1.40e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_5995 (32%) - MXAN_2785 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 39% E-Value: 1.83e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (31%) - MXAN_2785 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 38% E-Value: 2.73e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4072 (29%) - MXAN_2785 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 38% E-Value: 4.51e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (29%) - MXAN_2785 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 37% E-Value: 2.24e-15

Method

DB Source

Type

Publication

physical association

slr1909 (29%) - sll1003 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 21% Positives: 40% E-Value: 6.09e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1305 (29%) - slr2104 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 21% Positives: 39% E-Value: 1.71e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

zraR (35%) - zraS (12%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 21% Positives: 31% E-Value: 4.81e-22

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

MXAN_5995 (32%) - sdeK (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 37% E-Value: 3.95e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (27%) - MXAN_2785 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 36% E-Value: 5.69e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (28%) - MXAN_2785 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 37% E-Value: 2.92e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (29%) - MXAN_7363 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 37% E-Value: 1.04e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (27%) - MXAN_2785 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 36% E-Value: 5.69e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (31%) - MXAN_7363 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 36% E-Value: 8.22e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr1037 (34%) - slr1393 (12%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 6.96e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1584 (24%) - CcaS (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 20% Positives: 37% E-Value: 1.90e-10

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation reaction	Hirose Y et al. (2008)

MXAN_2606 (29%) - sdeK (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 36% E-Value: 4.83e-10

Method

DB Source

Type

Publication

physical association

MXAN_3450 (24%) - MXAN_2785 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 34% E-Value: 8.50e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (31%) - sdeK (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 35% E-Value: 3.82e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (29%) - sdeK (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 37% E-Value: 4.99e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (32%) - MXAN_0459 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 33% E-Value: 6.50e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (33%) - MXAN_0459 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 34% E-Value: 3.12e-21

Method

DB Source

Type

Publication

physical association

sll1905 (37%) - sll1353 (10%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 3.57e-13

Method

DB Source

Type

Publication

physical association

MXAN_5995 (32%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 1.96e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (33%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 2.02e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (33%) - MXAN_1350 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 34% E-Value: 5.89e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (33%) - phoR1 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 1.36e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7143 (27%) - sdeK (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 36% E-Value: 2.83e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (27%) - sdeK (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 35% E-Value: 1.23e-09

Method

DB Source

Type

Publication

physical association

phoP2 (27%) - sdeK (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 34% E-Value: 3.70e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (31%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 2.92e-15

Method

DB Source

Type

Publication

physical association

MXAN_4645 (31%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 31% E-Value: 6.30e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1349 (32%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 31% E-Value: 1.11e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1349 (32%) - phoR1 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 30% E-Value: 1.60e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (29%) - MXAN_0459 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 8.21e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4072 (29%) - MXAN_0459 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 1.60e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP1 (31%) - phoR1 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 30% E-Value: 4.66e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

divK (28%) - BruAb1_0598 (11%) (Brucella abortus)

Geometric mean of BLAST Identity: 18% Positives: 33% E-Value: 1.27e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Hallez R et al. (2007)

slr1400 (25%) - sll0474 (12%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 32% E-Value: 5.89e-12

Method

DB Source

Type

Publication

physical association

slr1760 (31%) - slr1759 (11%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 1.23e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

yycF (34%) - yycG (10%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 18% Positives: 32% E-Value: 5.15e-16

Method	DB Source	Type	Publication
enzymatic study		physical association	Fukuchi K et al. (2000)

glnG (31%) - glnL (10%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 5.89e-16

Method

DB Source

Type

Publication

physical association

Salinas P et al. (2003)

divK (30%) - pleC (11%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 18% Positives: 33% E-Value: 2.24e-15

Method

DB Source

Type

Publication

dephosphorylation

phosphorylation

pleD (31%) - pleC (11%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 2.73e-13

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

pleD (31%) - divJ (10%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 6.30e-14

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

MXAN_2606 (11%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 2.39e-13

Method

DB Source

Type

Publication

physical association

MXAN_2606 (29%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 5.16e-12

Method

DB Source

Type

Publication

physical association

MXAN_2606 (29%) - MXAN_1350 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 32% E-Value: 1.50e-11

Method

DB Source

Type

Publication

physical association

pilR (30%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 2.24e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (30%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 4.82e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (30%) - pilS (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 32% E-Value: 2.55e-19

Method

DB Source

Type

Publication

physical association

pilR (30%) - MXAN_1350 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 32% E-Value: 1.40e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (29%) - phoR1 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 3.45e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (31%) - MXAN_1350 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 32% E-Value: 1.83e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4072 (29%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 32% E-Value: 4.82e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4072 (29%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 1.04e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (28%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 3.12e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (28%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 6.73e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (28%) - phoR1 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 4.51e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (31%) - pilS (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 32% E-Value: 2.16e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (31%) - phoR1 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 2.73e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (29%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 32% E-Value: 2.47e-14

Method

DB Source

Type

Publication

physical association

MXAN_5853 (29%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 5.33e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cpxR (35%) - cpxA (8%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 3.82e-11

Method	DB Source	Type	Publication
unspecified method		physical association	Nakayama S et al. (2003)

sll1229 (28%) - sll1228 (10%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 17% Positives: 31% E-Value: 9.72e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll0649 (29%) - slr0533 (10%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 1.11e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

torR (28%) - torS (10%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 17% Positives: 27% E-Value: 1.77e-08

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

divK (28%) - pleC (11%) (Brucella abortus - Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 17% Positives: 33% E-Value: 4.98e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Hallez R et al. (2007)

divK (30%) - divJ (10%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 17% Positives: 32% E-Value: 5.15e-16

Method

DB Source

Type

Publication

protein kinase assay

phosphorylation

Paul R et al. (2008)

asgD (27%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 6.09e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

nla28 (33%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 1.60e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (27%) - pilS (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 32% E-Value: 6.95e-17

Method

DB Source

Type

Publication

physical association

MXAN_2606 (29%) - pilS (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 33% E-Value: 2.73e-17

Method

DB Source

Type

Publication

physical association

phoP2 (27%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 1.83e-13

Method

DB Source

Type

Publication

physical association

phoP2 (27%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 3.95e-12

Method

DB Source

Type

Publication

physical association

phoP2 (27%) - pilS (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 31% E-Value: 2.09e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (26%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 2.03e-12

Method

DB Source

Type

Publication

physical association

MXAN_1680 (26%) - MXAN_1350 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 31% E-Value: 5.89e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7143 (27%) - phoR1 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 31% E-Value: 2.03e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (27%) - phoR1 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 2.65e-12

Method

DB Source

Type

Publication

physical association

MXAN_4645 (31%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 3.23e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (27%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 6.09e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (27%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 1.31e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (33%) - MXAN_0461 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 6.51e-15

Method

DB Source

Type

Publication

physical association

slr1584 (24%) - sll1475 (10%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 1.40e-09

Method

DB Source

Type

Publication

physical association

slr1909 (29%) - slr0210 (9%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 2.65e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

hnr (27%) - arcB (9%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 16% Positives: 31% E-Value: 2.24e-11

Method	DB Source	Type	Publication
enzymatic study		physical association	Mika F et al. (2005)

kdpE (26%) - kdpD (10%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 4.99e-11

Method	DB Source	Type	Publication
adenylate cyclase complementation		physical association	Luttmann D et al. (2009)
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)
enzymatic study		physical association	Heermann R et al. (2003)
protein kinase assay		physical association	Luttmann D et al. (2009)

ompR (34%) - envZ (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 3.34e-11

Method	DB Source	Type	Publication
electrophoretic mobility shift assay		physical association	Harlocker SL et al. (1995)
far western blotting		physical association	Cai SJ et al. (2002)
pull down		physical association	Cai SJ et al. (2002)

MXAN_7143 (27%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 1.55e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (27%) - MXAN_7059 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 6.97e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (29%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 2.65e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (29%) - MXAN_7059 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 2.74e-09

Method

DB Source

Type

Publication

physical association

aglZ (23%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 30% E-Value: 8.80e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cheB1 (24%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 1.71e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cheB1 (24%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 3.70e-10

Method

DB Source

Type

Publication

physical association

aglZ (23%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 1.90e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

frzS (23%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 30% E-Value: 7.70e-12

Method

DB Source

Type

Publication

physical association

MXAN_3450 (24%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 9.09e-13

Method

DB Source

Type

Publication

physical association

MXAN_3450 (24%) - MXAN_7206 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 1.96e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (24%) - pilS (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 30% E-Value: 1.04e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cheB1 (24%) - MXAN_1350 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 1.08e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

frzS (23%) - MXAN_1350 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 31% E-Value: 4.83e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6149 (23%) - MXAN_2606 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 32% E-Value: 5.51e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (27%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 2.03e-08

Method

DB Source

Type

Publication

physical association

pilR (30%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 2.48e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (26%) - pilS (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 32% E-Value: 1.07e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (24%) - phoR1 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 1.31e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (30%) - MXAN_3451 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 6.52e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (29%) - MXAN_3451 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 6.97e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4072 (29%) - MXAN_3451 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 1.40e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (27%) - MXAN_7059 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 6.97e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4245 (21%) - MXAN_0459 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 3.94e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

vieA (26%) - vieS (10%) (Vibrio cholerae O395)

Geometric mean of BLAST Identity: 16% Positives: 31% E-Value: 2.48e-10

Method	DB Source	Type	Publication
in-gel kinase assay		direct interaction	Martinez-Wilson HF et al. (2008)

basR (26%) - basS (8%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 1.19e-08

Method	DB Source	Type	Publication
coimmunoprecipitation		physical association	Kato A et al. (2004)

sll0797 (23%) - sll0798 (10%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 7.45e-11

Method

DB Source

Type

Publication

physical association

sll1291 (22%) - sasA (10%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 15% Positives: 29% E-Value: 7.20e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

cheY (24%) - arcB (9%) (Escherichia coli O157:H7 - Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 29% E-Value: 2.74e-09

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Kato M et al. (1999)

basR (27%) - basS (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 5.16e-08

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

creB (28%) - creC (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 2.48e-10

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

cheB1 (24%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 1.90e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (24%) - MXAN_7059 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 1.04e-08

Method

DB Source

Type

Publication

physical association

MXAN_6149 (23%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 30% E-Value: 6.10e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (33%) - MXAN_5211 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 1.40e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (33%) - MXAN_7398 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 2.83e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (26%) - MXAN_7059 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 28% E-Value: 1.08e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (24%) - MXAN_3451 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 2.65e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (27%) - MXAN_3451 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 5.34e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (31%) - MXAN_5211 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 4.36e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (31%) - MXAN_7398 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 8.80e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4072 (29%) - MXAN_7398 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 1.45e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (29%) - MXAN_7398 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 7.45e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1708 (20%) - slr1805 (9%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 4.52e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1592 (23%) - slr1414 (9%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 2.56e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_5995 (32%) - MXAN_6688 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 3.02e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (27%) - MXAN_5211 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 9.10e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (29%) - MXAN_5211 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 3.57e-09

Method

DB Source

Type

Publication

physical association

MXAN_0460 (33%) - MXAN_6688 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 1.45e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (27%) - MXAN_7398 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 5.52e-10

Method

DB Source

Type

Publication

physical association

pilR (30%) - MXAN_5211 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 3.34e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1349 (32%) - MXAN_6688 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 1.71e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (29%) - MXAN_3606 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 1.66e-10

Method

DB Source

Type

Publication

physical association

MXAN_5212 (22%) - MXAN_7059 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 28% E-Value: 3.95e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (28%) - MXAN_7398 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 9.41e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (27%) - MXAN_5211 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 9.10e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (27%) - MXAN_7398 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 1.83e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (29%) - MXAN_5211 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 3.70e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (29%) - MXAN_7142 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 4.83e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Cj1227c (23%) - A3ZCK1 (8%) (Campylobacter jejuni - Campylobacter jejuni subsp jejuni HB93-13)

Geometric mean of BLAST Identity: 14% Positives: 28% E-Value: 8.81e-08

Method	DB Source	Type	Publication
adenylate cyclase complementation		physical association	Svensson SL et al. (2009)

regR (19%) - regS (9%) (Bradyrhizobium japonicum)

Geometric mean of BLAST Identity: 13% Positives: 26% E-Value: 7.70e-08

Method	DB Source	Type	Publication
affinity chromatography technology		physical association	Emmerich R et al. (1999)

asgD (27%) - MXAN_6688 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 9.41e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (29%) - MXAN_6688 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 3.70e-10

Method

DB Source

Type

Publication

physical association

MXAN_3450 (24%) - MXAN_5211 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 1.36e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cheB1 (24%) - MXAN_7398 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 23% E-Value: 5.16e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

aglZ (23%) - MXAN_7398 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 24% E-Value: 2.65e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6149 (23%) - MXAN_7398 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 25% E-Value: 1.66e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (27%) - MXAN_6688 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 2.83e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (27%) - MXAN_5211 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 2.74e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (26%) - MXAN_5211 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 1.40e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4072 (29%) - MXAN_6688 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 23% E-Value: 7.45e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (28%) - MXAN_6688 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 4.83e-10

Method

DB Source

Type

Publication

physical association