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The Microbial Protein Interaction Database

Interaction Evidences

phoP - phoP ( Bacillus subtilis )

Protein A	Protein B
P13792 Alkaline phosphatase synthesis transcriptional regulatory protein phoP phoP BSU29110	P13792 Alkaline phosphatase synthesis transcriptional regulatory protein phoP phoP BSU29110
CMR Search...	CMR Search...
GO MF: DNA binding GO MF: two-component response regulator activity GO CC: cytoplasm GO BP: transcription GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p... GO BP: phosphate transport	GO MF: DNA binding GO MF: two-component response regulator activity GO CC: cytoplasm GO BP: transcription GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p... GO BP: phosphate transport

List of evidences (209)

Experiments (2)

Method	DB Source	Type	Publication
genetic interference		physical association	Chen Y et al. (2003)
x-ray crystallography		physical association	Chen Y et al. (2003)

Interologs (204)

cpxR (42%) - cpxR (42%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 42% Positives: 58% E-Value: 5.09e-44

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_4164 (40%) - MXAN_4164 (40%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 40% Positives: 65% E-Value: 2.29e-44

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (42%) - phoP2 (38%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 40% Positives: 56% E-Value: 3.30e-39

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (38%) - MXAN_5313 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 40% Positives: 56% E-Value: 3.30e-39

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoB (39%) - phoB (39%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 39% Positives: 59% E-Value: 7.61e-40

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

creB (39%) - creB (39%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 39% Positives: 55% E-Value: 1.34e-36

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

ompR (38%) - ompR (38%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 38% Positives: 57% E-Value: 1.81e-41

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoB (39%) - ompR (38%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 38% Positives: 58% E-Value: 1.17e-40

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

ompR (38%) - phoB (39%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 38% Positives: 58% E-Value: 1.17e-40

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

baeR (38%) - baeR (38%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 38% Positives: 59% E-Value: 6.88e-41

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

cusR (38%) - cusR (38%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 38% Positives: 55% E-Value: 7.12e-38

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoP2 (38%) - phoP2 (38%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 38% Positives: 52% E-Value: 1.06e-33

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

kdpE (36%) - creB (39%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 37% Positives: 55% E-Value: 1.14e-35

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

creB (39%) - kdpE (36%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 37% Positives: 55% E-Value: 1.14e-35

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_4164 (40%) - MXAN_1680 (32%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 36% Positives: 57% E-Value: 7.88e-33

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (32%) - MXAN_4164 (40%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 36% Positives: 57% E-Value: 7.88e-33

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cusR (38%) - yedW (33%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 35% Positives: 53% E-Value: 1.10e-34

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

yedW (33%) - cusR (38%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 35% Positives: 53% E-Value: 1.10e-34

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_3450 (35%) - MXAN_3450 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 54% E-Value: 1.81e-33

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

arcA (34%) - arcA (34%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 34% Positives: 50% E-Value: 3.92e-28

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

rstA (32%) - kdpE (36%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 34% Positives: 53% E-Value: 1.54e-32

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

kdpE (36%) - rstA (32%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 34% Positives: 53% E-Value: 1.54e-32

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

yedW (33%) - yedW (33%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 33% Positives: 52% E-Value: 1.70e-31

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_1680 (32%) - MXAN_3450 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 33% Positives: 51% E-Value: 2.22e-27

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (35%) - MXAN_1680 (32%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 33% Positives: 51% E-Value: 2.22e-27

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

rstA (32%) - rstA (32%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 32% Positives: 52% E-Value: 2.45e-30

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

qseB (32%) - qseB (32%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 32% Positives: 57% E-Value: 1.30e-31

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

sll0797 (30%) - sll0797 (30%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 30% Positives: 51% E-Value: 2.63e-24

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_1349 (42%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 45% E-Value: 4.04e-33

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_1349 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 45% E-Value: 4.04e-33

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5212 (27%) - MXAN_3450 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 51% E-Value: 1.94e-27

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (35%) - MXAN_5212 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 51% E-Value: 1.94e-27

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP (29%) - phoP (29%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 29% Positives: 52% E-Value: 1.82e-25

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)
molecular sieving		physical association	Bachhawat P et al. (2007)
x-ray crystallography		physical association	Bachhawat P et al. (2007)

phoP2 (38%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 29% Positives: 42% E-Value: 2.81e-26

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (22%) - phoP2 (38%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 29% Positives: 42% E-Value: 2.81e-26

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_4164 (40%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 29% Positives: 47% E-Value: 1.30e-31

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_4164 (40%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 29% Positives: 47% E-Value: 1.30e-31

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

torR (28%) - torR (28%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 28% Positives: 48% E-Value: 8.74e-20

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_2606 (22%) - MXAN_5995 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 28% Positives: 42% E-Value: 4.19e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (35%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 28% Positives: 42% E-Value: 4.19e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (38%) - MXAN_6149 (21%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 28% Positives: 45% E-Value: 7.91e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6149 (21%) - phoP2 (38%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 28% Positives: 45% E-Value: 7.91e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (42%) - MXAN_7363 (19%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 28% Positives: 38% E-Value: 4.63e-29

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (19%) - MXAN_5313 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 28% Positives: 38% E-Value: 4.63e-29

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (35%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 43% E-Value: 3.67e-26

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_3450 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 43% E-Value: 3.67e-26

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_4164 (40%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 45% E-Value: 4.32e-31

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (18%) - MXAN_4164 (40%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 45% E-Value: 4.32e-31

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (38%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 40% E-Value: 6.26e-22

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoP2 (38%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 40% E-Value: 9.33e-26

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (18%) - phoP2 (38%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 40% E-Value: 9.33e-26

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (18%) - phoP2 (38%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 40% E-Value: 6.26e-22

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_4164 (40%) - MXAN_2785 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 41% E-Value: 4.33e-27

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_4164 (40%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 41% E-Value: 4.33e-27

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP3 (37%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 41% E-Value: 1.59e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (18%) - phoP3 (37%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 41% E-Value: 1.59e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (35%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 41% E-Value: 1.22e-25

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (18%) - MXAN_3450 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 41% E-Value: 1.22e-25

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoP2 (38%) - MXAN_7143 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 39% E-Value: 4.79e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7143 (17%) - phoP2 (38%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 39% E-Value: 4.79e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (42%) - pilR (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 40% E-Value: 1.30e-27

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (15%) - MXAN_5313 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 40% E-Value: 1.30e-27

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (17%) - phoP2 (38%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 39% E-Value: 3.67e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (38%) - MXAN_5853 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 39% E-Value: 3.67e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll0649 (45%) - sll1592 (13%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 24% Positives: 36% E-Value: 3.10e-29

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1592 (13%) - sll0649 (45%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 24% Positives: 36% E-Value: 3.10e-29

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_4072 (16%) - phoP2 (38%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 39% E-Value: 4.64e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (38%) - MXAN_4072 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 39% E-Value: 4.64e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_5995 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 37% E-Value: 1.40e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_3450 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 37% E-Value: 1.22e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (35%) - MXAN_2785 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 37% E-Value: 1.40e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (35%) - MXAN_2785 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 37% E-Value: 1.22e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (42%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 40% E-Value: 1.03e-28

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (14%) - MXAN_5313 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 40% E-Value: 1.03e-28

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (17%) - MXAN_3450 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 40% E-Value: 4.79e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (35%) - MXAN_5853 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 40% E-Value: 4.79e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (15%) - MXAN_5995 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 37% E-Value: 6.27e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (15%) - MXAN_3450 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 38% E-Value: 5.48e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (35%) - pilR (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 37% E-Value: 6.27e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (35%) - pilR (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 38% E-Value: 5.48e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6296 (15%) - MXAN_5995 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 37% E-Value: 2.15e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6296 (15%) - MXAN_3450 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 37% E-Value: 1.88e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (35%) - MXAN_6296 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 37% E-Value: 2.15e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (35%) - MXAN_6296 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 37% E-Value: 1.88e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 35% E-Value: 7.40e-19

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1680 (32%) - pilR (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 36% E-Value: 6.70e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (15%) - MXAN_1680 (32%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 36% E-Value: 6.70e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (14%) - MXAN_5995 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 37% E-Value: 4.96e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (35%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 37% E-Value: 4.96e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5212 (27%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 39% E-Value: 1.31e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (18%) - MXAN_5212 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 39% E-Value: 1.31e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1905 (22%) - slr1305 (21%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 21% Positives: 32% E-Value: 1.35e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1305 (21%) - sll1905 (22%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 21% Positives: 32% E-Value: 1.35e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_6149 (21%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 37% E-Value: 2.09e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_6149 (21%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 37% E-Value: 2.09e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

fixJ (20%) - fixJ (20%) (Rhizobium meliloti (Sinorhizobium meliloti))

Geometric mean of BLAST Identity: 20% Positives: 36% E-Value: 3.12e-09

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Gouet P et al. (1999)

sll1228 (18%) - sll1229 (22%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 4.97e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1229 (22%) - sll1228 (18%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 4.97e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_7396 (18%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 33% E-Value: 2.46e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 33% E-Value: 2.46e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

frzS (19%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 36% E-Value: 2.16e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (22%) - frzS (19%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 36% E-Value: 2.16e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7363 (19%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 29% E-Value: 3.93e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_7363 (19%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 29% E-Value: 3.93e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

glnG (19%) - glnG (19%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 19% Positives: 34% E-Value: 1.11e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Salinas P et al. (2003)

MXAN_2606 (22%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 1.65e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (18%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 1.65e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6149 (21%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 34% E-Value: 4.65e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6149 (21%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 35% E-Value: 6.94e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (18%) - MXAN_6149 (21%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 35% E-Value: 6.94e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (18%) - MXAN_6149 (21%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 34% E-Value: 4.65e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4072 (16%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 1.22e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_4072 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 1.22e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 30% E-Value: 2.46e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_2785 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 30% E-Value: 2.46e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7024 (13%) - MXAN_5212 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 35% E-Value: 1.31e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5212 (27%) - MXAN_7024 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 35% E-Value: 1.31e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (17%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 9.68e-15

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5853 (17%) - MXAN_6149 (21%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 34% E-Value: 2.73e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6149 (21%) - MXAN_5853 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 34% E-Value: 2.73e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_5853 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 9.68e-15

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

TP_0519 (18%) - TP_0519 (18%) (Treponema pallidum)

Geometric mean of BLAST Identity: 18% Positives: 28% E-Value: 6.07e-13

Method

DB Source

Type

Publication

two hybrid array

physical association

Titz B et al. (2008)

slr2024 (18%) - slr2024 (18%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 33% E-Value: 2.72e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr2100 (23%) - slr2098 (14%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 28% E-Value: 4.80e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr2098 (14%) - slr2100 (23%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 28% E-Value: 4.80e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_7396 (18%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 5.49e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (18%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 5.49e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cheB1 (15%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 3.68e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (22%) - cheB1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 3.68e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

nla28 (18%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 2.02e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (18%) - nla28 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 2.02e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (15%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 1.11e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (22%) - pilR (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 1.11e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (14%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 8.75e-16

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 8.75e-16

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7363 (19%) - MXAN_2785 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 25% E-Value: 1.31e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_7363 (19%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 25% E-Value: 1.31e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6296 (15%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 3.80e-15

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (22%) - MXAN_6296 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 3.80e-15

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

frzZ (14%) - MXAN_2606 (22%) (Myxococcus xanthus (strain DK 1622) - Myxococcus xanthus)

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 2.82e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (22%) - frzZ (14%) (Myxococcus xanthus (strain DK 1622) - Myxococcus xanthus)

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 2.82e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

slr2104 (14%) - slr1305 (21%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 1.26e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1305 (21%) - slr2104 (14%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 1.26e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

asgD (18%) - MXAN_7143 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 2.82e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7143 (17%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 2.82e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (17%) - MXAN_0460 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 1.11e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

pilR (15%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 3.68e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (18%) - pilR (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 3.68e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 5.50e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 8.19e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (18%) - MXAN_2785 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 8.19e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

asgD (18%) - MXAN_2785 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 5.50e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_2785 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 26% E-Value: 8.20e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6296 (15%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 1.26e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6296 (15%) - frzS (19%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 31% E-Value: 1.11e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (18%) - MXAN_6296 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 1.26e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

frzS (19%) - MXAN_6296 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 31% E-Value: 1.11e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr1760 (19%) - slr1759 (13%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 3.44e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1759 (13%) - slr1760 (19%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 3.44e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

cheB1 (15%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 8.20e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cheB1 (15%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 1.22e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (18%) - cheB1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 1.22e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (18%) - cheB1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 8.20e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (15%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 2.47e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (18%) - pilR (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 2.47e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (14%) - MXAN_7143 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 1.50e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (14%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 1.95e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (14%) - MXAN_7396 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 2.91e-15

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (18%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 2.91e-15

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7143 (17%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 1.50e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (18%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 1.95e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4072 (16%) - MXAN_0460 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 1.50e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (17%) - MXAN_4072 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 1.50e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 2.91e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_4072 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 4.07e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (14%) - MXAN_2785 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 2.91e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4072 (16%) - MXAN_2785 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 4.07e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6296 (15%) - MXAN_7143 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 6.49e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6296 (15%) - asgD (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 8.48e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_6296 (15%) - MXAN_0460 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 4.65e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7143 (17%) - MXAN_6296 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 6.49e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (18%) - MXAN_6296 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 8.48e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_0460 (17%) - MXAN_6296 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 4.65e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (17%) - MXAN_4072 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 1.60e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4072 (16%) - MXAN_5853 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 1.60e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

bvgA (16%) - bvgS (14%) (Bordetella pertussis)

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 4.07e-09

Method	DB Source	Type	Publication
genetic interference		physical association	Merkel TJ et al. (2003)

bvgS (14%) - bvgA (16%) (Bordetella pertussis)

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 4.07e-09

Method	DB Source	Type	Publication
genetic interference		physical association	Merkel TJ et al. (2003)

cheB (15%) - cheY (15%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 1.04e-08

Method	DB Source	Type	Publication
unspecified method		physical association	Ninfa EG et al. (1991)

cheY (15%) - cheB (15%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 1.04e-08

Method	DB Source	Type	Publication
unspecified method		physical association	Ninfa EG et al. (1991)

slr1594 (15%) - slr1594 (15%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 15% Positives: 28% E-Value: 2.31e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

evgA (11%) - evgS (20%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 32% E-Value: 1.14e-11

Method	DB Source	Type	Publication
surface plasmon resonance		physical association	Perraud AL et al. (2000)
surface plasmon resonance		physical association	Tanabe H et al. (1998)

evgS (20%) - evgA (11%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 32% E-Value: 1.14e-11

Method	DB Source	Type	Publication
surface plasmon resonance		physical association	Perraud AL et al. (2000)
surface plasmon resonance		physical association	Tanabe H et al. (1998)

arcB (15%) - cheY (15%) (Escherichia coli O157:H7 - Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 28% E-Value: 7.18e-10

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Kato M et al. (1999)

cheY (15%) - arcB (15%) (Escherichia coli O157:H7 - Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 28% E-Value: 7.18e-10

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Kato M et al. (1999)

MXAN_0460 (17%) - frzZ (14%) (Myxococcus xanthus - Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 3.44e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

frzZ (14%) - MXAN_0460 (17%) (Myxococcus xanthus - Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 3.44e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cheY (14%) - HP_0392 (13%) (Helicobacter pylori (Campylobacter pylori))

Geometric mean of BLAST Identity: 14% Positives: 29% E-Value: 2.23e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Rain JC et al. (2001)

HP_0392 (13%) - cheY (14%) (Helicobacter pylori (Campylobacter pylori))

Geometric mean of BLAST Identity: 14% Positives: 29% E-Value: 2.23e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Rain JC et al. (2001)

slr1594 (15%) - slr1759 (13%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 1.27e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1759 (13%) - slr1594 (15%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 1.27e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

arcB (15%) - hnr (13%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 1.89e-10

Method	DB Source	Type	Publication
enzymatic study		physical association	Mika F et al. (2005)

hnr (13%) - arcB (15%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 1.89e-10

Method	DB Source	Type	Publication
enzymatic study		physical association	Mika F et al. (2005)

vieA (16%) - vieS (12%) (Vibrio cholerae O395)

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 4.35e-07

Method	DB Source	Type	Publication
in-gel kinase assay		direct interaction	Martinez-Wilson HF et al. (2008)

vieS (12%) - vieA (16%) (Vibrio cholerae O395)

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 4.35e-07

Method	DB Source	Type	Publication
in-gel kinase assay		direct interaction	Martinez-Wilson HF et al. (2008)

Domain-Domain Interactions (3)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Response_reg
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Trans_reg_C
structural domain contact	3DID	predicted interaction	Trans_reg_C	Trans_reg_C

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