About
Search
Interaction Evidences
Help
Contact Us

The Microbial Protein Interaction Database

Interaction Evidences

bvgS - bvgA ( Bordetella pertussis )

Protein A	Protein B
P16575 Virulence sensor protein bvgS bvgS BP1877	P0A4H2 Virulence factors putative positive transcription regulator bvgA bvgA BP1878
CMR Search...	CMR Search...
GO MF: transporter activity GO MF: two-component sensor activity GO MF: ATP binding GO MF: two-component response regulator activity GO CC: integral to membrane GO CC: outer membrane-bounded periplasmic space GO CC: plasma membrane GO BP: transport GO BP: pathogenesis GO BP: regulation of transcription, DNA-dependent GO BP: peptidyl-histidine phosphorylation GO BP: two-component signal transduction system (p...	GO MF: transcription factor activity GO MF: sequence-specific DNA binding GO MF: two-component response regulator activity GO CC: intracellular GO BP: transcription GO BP: pathogenesis GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...

List of evidences (84)

Experiments (1)

Method	DB Source	Type	Publication
genetic interference		physical association	Merkel TJ et al. (2003)

Interologs (77)

evgS (26%) - evgA (34%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 30% Positives: 50% E-Value: 4.92e-77

Method	DB Source	Type	Publication
surface plasmon resonance		physical association	Perraud AL et al. (2000)
surface plasmon resonance		physical association	Tanabe H et al. (1998)

MXAN_2785 (13%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 4.51e-30

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (8%) - MXAN_6149 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 1.50e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (8%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 1.15e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (13%) - MXAN_5995 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 3.82e-25

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (13%) - MXAN_7363 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 4.67e-27

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (13%) - MXAN_4164 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 1.31e-25

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (8%) - phoP1 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 1.19e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1353 (9%) - sll1905 (21%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 1.50e-25

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

slr0210 (8%) - slr1909 (26%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 6.10e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

arcB (13%) - cheY (15%) (Escherichia coli O157:H7 - Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 1.31e-29

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Kato M et al. (1999)

MXAN_2606 (6%) - MXAN_6149 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 6.98e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (8%) - phoP2 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 5.01e-13

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR1 (8%) - phoP2 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 1.04e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

sdeK (8%) - phoP2 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 1.46e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

vieS (16%) - vieA (13%) (Vibrio cholerae O395)

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 3.13e-23

Method	DB Source	Type	Publication
in-gel kinase assay		direct interaction	Martinez-Wilson HF et al. (2008)

slr1393 (10%) - slr1037 (18%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 1.04e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1759 (11%) - slr1760 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 1.40e-27

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1805 (5%) - sll1708 (32%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 3.96e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

phoR2 (5%) - MXAN_6149 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 23% E-Value: 1.36e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (6%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 6.54e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (6%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 23% E-Value: 5.35e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1003 (6%) - slr1909 (26%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 22% E-Value: 1.84e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1414 (5%) - sll1592 (25%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 22% E-Value: 2.32e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

creC (5%) - creB (25%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 6.77e-10

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

MXAN_7398 (8%) - cheB1 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 1.46e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (5%) - MXAN_6149 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 23% E-Value: 1.66e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (6%) - phoP2 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 2.85e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

pilS (7%) - phoP2 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 23% E-Value: 1.72e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (6%) - phoP2 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 22% E-Value: 2.32e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

sdeK (8%) - MXAN_5995 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 2.84e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (8%) - MXAN_1349 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 3.24e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (6%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 22% E-Value: 9.44e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR2 (5%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 22% E-Value: 1.04e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (8%) - MXAN_7363 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 1.19e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (8%) - MXAN_7363 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 2.48e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (8%) - MXAN_4164 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 3.36e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (8%) - MXAN_4164 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 1.19e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (5%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 7.48e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr0533 (6%) - sll0649 (18%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 19% E-Value: 9.76e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

narQ (4%) - narL (28%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 19% E-Value: 2.25e-13

Method	DB Source	Type	Publication
enzymatic study		physical association	Schroder I et al. (1994)

narQ (4%) - narP (30%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 20% E-Value: 5.35e-15

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

pleC (10%) - divK (12%) (Brucella abortus - Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.61e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Hallez R et al. (2007)

pleC (10%) - divK (12%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 6.31e-24

Method

DB Source

Type

Publication

dephosphorylation

phosphorylation

MXAN_2606 (6%) - cheB1 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 6.76e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (5%) - phoP2 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 20% E-Value: 5.55e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR3 (6%) - phoP2 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 21% E-Value: 4.85e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (5%) - phoP2 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 20% E-Value: 8.28e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR2 (5%) - phoP2 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 21% E-Value: 4.54e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (6%) - phoP2 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 21% E-Value: 4.10e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (6%) - MXAN_1349 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 7.23e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (6%) - MXAN_7363 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 5.53e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (6%) - MXAN_4164 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.56e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pdhS (9%) - divK (12%) (Brucella abortus)

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 5.53e-20

Method

DB Source

Type

Publication

two hybrid

physical association

Hallez R et al. (2007)

kdpD (6%) - A2VGV6 (17%) (Mycobacterium tuberculosis C - Mycobacterium tuberculosis)

Geometric mean of BLAST Identity: 10% Positives: 18% E-Value: 5.18e-14

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Davey CA et al. (2002)

prrB (5%) - prrA (20%) (Mycobacterium tuberculosis)

Geometric mean of BLAST Identity: 10% Positives: 18% E-Value: 2.94e-09

Method	DB Source	Type	Publication
enzymatic study		direct interaction	Nowak E et al. (2006)

divJ (8%) - divK (12%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 3.35e-21

Method

DB Source

Type

Publication

protein kinase assay

phosphorylation

Paul R et al. (2008)

MXAN_2606 (6%) - MXAN_5995 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 4.53e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (5%) - cheB1 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.61e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (6%) - cheB1 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 8.28e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1350 (5%) - cheB1 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 1.67e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (6%) - MXAN_7363 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 6.77e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (6%) - MXAN_4164 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 1.91e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4165 (6%) - MXAN_4164 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 7.49e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5996 (6%) - MXAN_4164 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.28e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (6%) - frzZ (13%) (Myxococcus xanthus (strain DK 1622) - Myxococcus xanthus)

Geometric mean of BLAST Identity: 9% Positives: 17% E-Value: 7.73e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

BruAb1_0598 (7%) - divK (12%) (Brucella abortus)

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 2.65e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Hallez R et al. (2007)

cpxA (5%) - cpxR (16%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 9% Positives: 16% E-Value: 4.11e-07

Method	DB Source	Type	Publication
unspecified method		physical association	Nakayama S et al. (2003)

yycG (5%) - yycF (16%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 9% Positives: 17% E-Value: 4.24e-12

Method	DB Source	Type	Publication
enzymatic study		physical association	Fukuchi K et al. (2000)

kinA (5%) - spo0F (16%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 9% Positives: 16% E-Value: 5.19e-10

Method	DB Source	Type	Publication
genetic interference		physical association	Stephenson SJ et al. (2002)

yedV (4%) - yedW (21%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 9% Positives: 18% E-Value: 4.85e-08

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

kdpD (5%) - kdpE (15%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 9% Positives: 16% E-Value: 2.18e-12

Method	DB Source	Type	Publication
adenylate cyclase complementation		physical association	Luttmann D et al. (2009)
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)
enzymatic study		physical association	Heermann R et al. (2003)
protein kinase assay		physical association	Luttmann D et al. (2009)

MXAN_5211 (5%) - MXAN_4164 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 5.55e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (5%) - MXAN_5995 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 16% E-Value: 6.34e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

envZ (5%) - ompR (15%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 8% Positives: 16% E-Value: 2.85e-08

Method	DB Source	Type	Publication
electrophoretic mobility shift assay		physical association	Harlocker SL et al. (1995)
far western blotting		physical association	Cai SJ et al. (2002)
pull down		physical association	Cai SJ et al. (2002)

MXAN_0460 (2%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 1.61e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (2%) - frzZ (13%) (Myxococcus xanthus - Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 9% E-Value: 2.33e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Domain-Domain Interactions (5)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Response_reg
structural domain contact	3DID	predicted interaction	Response_reg	HisKA
structural domain contact	3DID	predicted interaction	Response_reg	PAS
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Hpt
structural domain contact	3DID	predicted interaction	Response_reg	GerE

Secondary references (1)

Method	DB Source	Type	Publication
Not Curated		predicted interaction	Merkel TJ et al. (1998)

Please submit feedback about this entry to the curator