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The Microbial Protein Interaction Database

Interaction Evidences

slr1759 - slr1594 ( Synechocystis sp (strain PCC 6803) )

Protein A	Protein B
P73035 Sensor protein slr1759	P72972 PatA subfamily slr1594
CMR Search...	CMR Search...
GO MF: two-component sensor activity GO MF: ATP binding GO MF: two-component response regulator activity GO CC: membrane GO BP: regulation of transcription, DNA-dependent GO BP: peptidyl-histidine phosphorylation GO BP: two-component signal transduction system (p...	GO MF: two-component response regulator activity GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...

List of evidences (125)

Experiments (1)

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

Interologs (121)

sphS (4%) - slr1594 (100%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 21% Positives: 27% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sasA (4%) - slr1594 (100%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 21% Positives: 28% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

ETR1 (8%) - slr1214 (40%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 6.83e-55

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sasA (4%) - sll1291 (32%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 9.57e-41

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr2098 (17%) - slr2100 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 2.43e-52

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1905 (18%) - slr1305 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 20% E-Value: 3.62e-56

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1228 (9%) - sll1229 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 9.60e-29

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_7206 (9%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 3.21e-12

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7206 (9%) - MXAN_2785 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 16% E-Value: 1.03e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (10%) - MXAN_2785 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 1.18e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (9%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 8.70e-26

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (9%) - MXAN_2785 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 17% E-Value: 6.23e-24

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (9%) - MXAN_4164 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 16% E-Value: 4.48e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_4164 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 5.10e-26

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (7%) - MXAN_4164 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 1.88e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr2104 (11%) - slr1305 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 8% Positives: 16% E-Value: 1.48e-41

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1353 (8%) - sll1905 (9%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 4.17e-32

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

pleC (6%) - pleD (10%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 2.00e-22

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

divJ (6%) - pleD (10%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 4.18e-20

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

MXAN_2606 (7%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 6.46e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (7%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 1.34e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (9%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 1.44e-12

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (8%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 1.75e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_5995 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 7.88e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 1.64e-24

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 3.65e-24

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

asgD (6%) - MXAN_2785 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 2.15e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (7%) - MXAN_2785 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 15% E-Value: 4.33e-17

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7363 (9%) - MXAN_5313 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 15% E-Value: 9.62e-25

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll0474 (6%) - slr1400 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 1.75e-22

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

slr0210 (6%) - slr1909 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.59e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr0533 (6%) - sll0649 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.30e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_2606 (7%) - MXAN_5995 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 14% E-Value: 2.90e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (6%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 3.00e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (8%) - MXAN_2606 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 13% E-Value: 6.04e-19

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

asgD (6%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 13% E-Value: 6.69e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (5%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.44e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (9%) - MXAN_4645 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 14% E-Value: 7.90e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (7%) - MXAN_4645 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 13% E-Value: 3.31e-17

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_4645 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 13% E-Value: 9.00e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (5%) - MXAN_2785 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 4.63e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (5%) - MXAN_4164 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 1.88e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr1147 (4%) - slr1783 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 2.72e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

slr1393 (5%) - slr1037 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 2.37e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

yycG (4%) - yycF (9%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 6% Positives: 12% E-Value: 1.10e-16

Method	DB Source	Type	Publication
enzymatic study		physical association	Fukuchi K et al. (2000)

yedV (3%) - yedW (9%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 3.43e-10

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

glnL (4%) - glnG (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 7.16e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Salinas P et al. (2003)

MXAN_7059 (4%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 1.22e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (4%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 1.14e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7059 (4%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 2.54e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5314 (5%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 3.10e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5314 (5%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 6.91e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (4%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 6.92e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

pilS (4%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 1.44e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1350 (5%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 8.16e-16

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR2 (4%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 9.66e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR2 (4%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 2.01e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (4%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 6.26e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (4%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 5.85e-10

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR3 (4%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 1.30e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (5%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 6.46e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (4%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 4.79e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

sdeK (4%) - MXAN_5995 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 2.15e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (4%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 4.48e-10

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

sdeK (4%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 9.99e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (4%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 3.92e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (5%) - MXAN_4645 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 3.32e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (6%) - MXAN_4645 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 12% E-Value: 1.65e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (3%) - MXAN_2785 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 3.11e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7059 (4%) - MXAN_2785 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 8.18e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5211 (3%) - MXAN_2785 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 1.35e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (3%) - MXAN_4164 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 1.35e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (4%) - MXAN_4164 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 3.55e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (3%) - MXAN_4164 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 5.85e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (4%) - MXAN_5313 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 6.47e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (5%) - MXAN_5313 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 7.14e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (4%) - MXAN_5313 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 4.96e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (5%) - MXAN_5995 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 3.21e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (5%) - phoP1 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 5.47e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

HP_0392 (3%) - cheY (8%) (Helicobacter pylori (Campylobacter pylori))

Geometric mean of BLAST Identity: 5% Positives: 8% E-Value: 2.81e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Rain JC et al. (2001)

sll1003 (4%) - slr1909 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 5% Positives: 11% E-Value: 7.90e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1305 (3%) - slr2104 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 5% Positives: 9% E-Value: 6.04e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1305 (3%) - sll1905 (9%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 5% Positives: 10% E-Value: 1.49e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

yedW (9%) - yedW (3%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 5% Positives: 8% E-Value: 1.76e-10

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

creC (4%) - creB (7%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 5% Positives: 10% E-Value: 2.01e-06

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

baeR (9%) - baeR (3%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 5% Positives: 8% E-Value: 3.67e-08

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_5211 (3%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 11% E-Value: 2.01e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (3%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 10% E-Value: 1.88e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (3%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 10% E-Value: 4.64e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (3%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 9% E-Value: 4.34e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (3%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 11% E-Value: 4.20e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoP3 (2%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 8% E-Value: 2.30e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (4%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 9% E-Value: 6.47e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR2 (4%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 10% E-Value: 9.03e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoP2 (2%) - asgD (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 9% E-Value: 1.76e-06

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoP2 (2%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 9% E-Value: 3.67e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (3%) - MXAN_4645 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 9% E-Value: 2.38e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5314 (5%) - MXAN_4645 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 10% E-Value: 1.70e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (3%) - MXAN_4645 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 10% E-Value: 1.03e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (5%) - MXAN_4645 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 11% E-Value: 4.48e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (3%) - MXAN_4164 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 9% E-Value: 2.38e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (4%) - MXAN_5313 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 5% Positives: 10% E-Value: 7.16e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr2100 (2%) - slr2098 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 4% Positives: 8% E-Value: 2.91e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

phoP (9%) - phoP (2%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 4% Positives: 8% E-Value: 5.12e-10

Method	DB Source	Type	Publication
genetic interference		physical association	Chen Y et al. (2003)
x-ray crystallography		physical association	Chen Y et al. (2003)

ompR (3%) - phoB (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 4% Positives: 9% E-Value: 1.44e-08

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoB (8%) - phoB (3%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 4% Positives: 9% E-Value: 2.46e-08

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

creB (7%) - creB (2%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 4% Positives: 7% E-Value: 2.63e-06

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

kdpE (2%) - creB (7%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 4% Positives: 8% E-Value: 1.76e-06

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

glnG (8%) - glnG (2%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 4% Positives: 8% E-Value: 4.49e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Salinas P et al. (2003)

yedW (3%) - cusR (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 4% Positives: 8% E-Value: 1.88e-08

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_3450 (2%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 4% Positives: 7% E-Value: 2.46e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_3450 (2%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 4% Positives: 7% E-Value: 5.48e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoP2 (2%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 4% Positives: 8% E-Value: 1.65e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1349 (2%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 4% Positives: 7% E-Value: 5.48e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (2%) - MXAN_2785 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 4% Positives: 8% E-Value: 1.76e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (2%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 4% Positives: 7% E-Value: 3.67e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (2%) - MXAN_7396 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 4% Positives: 8% E-Value: 8.18e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (2%) - MXAN_2785 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 4% Positives: 9% E-Value: 2.63e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (10%) - MXAN_4164 (2%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 4% Positives: 8% E-Value: 1.14e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (3%) - MXAN_4645 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 4% Positives: 7% E-Value: 3.21e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (2%) - MXAN_5313 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 4% Positives: 9% E-Value: 1.82e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Domain-Domain Interactions (3)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Response_reg
structural domain contact	3DID	predicted interaction	Response_reg	HisKA
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Hpt

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