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The Microbial Protein Interaction Database

Interaction Evidences

frzZ - MXAN_0460 ( Myxococcus xanthus-Myxococcus xanthus (strain DK 1622))

Protein A	Protein B
Q7BU54 Response regulator FrzZ frzZ	Q1DF43 Response regulator MXAN_0460
CMR Search...	CMR Search...
GO MF: two-component response regulator activity GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...	GO MF: two-component response regulator activity GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...

List of evidences (62)

Experiments (1)

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Interologs (60)

frzZ (86%) - MXAN_2606 (15%) (Myxococcus xanthus (strain DK 1622) - Myxococcus xanthus)

Geometric mean of BLAST Identity: 35% Positives: 48% E-Value: 1.95e-67

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_0460 (100%) - MXAN_0460 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 44% E-Value: 6.69e-72

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

aglZ (15%) - MXAN_3450 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 30% E-Value: 1.20e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr2100 (13%) - slr2098 (27%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 2.96e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_7396 (13%) - MXAN_3450 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 1.24e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_4645 (16%) - asgD (21%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 26% E-Value: 3.38e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (16%) - MXAN_5313 (21%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 26% E-Value: 2.26e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

ompR (12%) - phoB (23%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 1.24e-09

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoB (23%) - phoB (13%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 2.12e-09

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_4645 (16%) - MXAN_7143 (19%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 26% E-Value: 1.16e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

aglZ (15%) - MXAN_1349 (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 27% E-Value: 8.32e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (13%) - MXAN_7363 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 6.37e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - asgD (21%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 25% E-Value: 3.74e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - pilR (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 1.47e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (16%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 23% E-Value: 3.86e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (12%) - MXAN_4245 (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 3.27e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (13%) - pilR (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 9.51e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6149 (11%) - MXAN_5853 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 2.77e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

rstA (13%) - kdpE (18%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 1.16e-07

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

aglZ (15%) - MXAN_2606 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 3.06e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6149 (11%) - asgD (21%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 4.13e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - MXAN_6149 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 6.59e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - phoP2 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 3.74e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (16%) - MXAN_5995 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 1.47e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (16%) - MXAN_2606 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 2.86e-10

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5313 (13%) - phoP2 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 2.42e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

bvgA (10%) - bvgS (19%) (Bordetella pertussis)

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 4.00e-08

Method	DB Source	Type	Publication
genetic interference		physical association	Merkel TJ et al. (2003)

sll1229 (14%) - sll1228 (14%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 1.20e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll0649 (13%) - sll1592 (15%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 1.24e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

phoP (16%) - phoP (12%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 3.99e-12

Method	DB Source	Type	Publication
genetic interference		physical association	Chen Y et al. (2003)
x-ray crystallography		physical association	Chen Y et al. (2003)

cpxR (16%) - cpxR (13%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 2.12e-09

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoB (13%) - ompR (14%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 3.74e-10

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

kdpE (12%) - creB (15%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 3.50e-08

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

baeR (15%) - baeR (13%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 1.52e-07

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

cusR (16%) - cusR (12%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 1.20e-08

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_7396 (13%) - MXAN_2606 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 3.16e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - cheB1 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 6.16e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6149 (11%) - phoP2 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 4.13e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (16%) - MXAN_7396 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 1.57e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (13%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 3.61e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (13%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 4.27e-10

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (13%) - MXAN_5212 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 8.90e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - MXAN_4164 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 5.22e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7024 (14%) - MXAN_5212 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 8.05e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr1305 (11%) - slr2104 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 6.16e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1305 (11%) - sll1905 (15%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 23% E-Value: 3.27e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1759 (11%) - slr1760 (15%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 1.57e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

ompR (14%) - ompR (12%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 23% E-Value: 2.19e-10

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

evgA (11%) - evgS (16%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 23% E-Value: 9.51e-10

Method	DB Source	Type	Publication
surface plasmon resonance		physical association	Perraud AL et al. (2000)
surface plasmon resonance		physical association	Tanabe H et al. (1998)

MXAN_6149 (11%) - MXAN_2606 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 23% E-Value: 3.50e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (12%) - MXAN_4072 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 1.98e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (13%) - MXAN_4645 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 2.34e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll0797 (15%) - sll0797 (11%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 2.27e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr2024 (12%) - slr2024 (12%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 22% E-Value: 2.19e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

torR (13%) - torR (11%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 7.54e-07

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

torR (11%) - torS (12%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 22% E-Value: 2.51e-06

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

cusR (12%) - yedW (13%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 22% E-Value: 1.52e-07

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

sll1905 (11%) - slr1305 (12%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 20% E-Value: 5.05e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_6149 (11%) - MXAN_7396 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 19% E-Value: 1.92e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr2104 (9%) - slr1305 (12%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 19% E-Value: 5.77e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

Domain-Domain Interactions (1)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Response_reg

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