The Microbial Protein Interaction Database

physical association

asgD (13%) - pilR (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 36% Positives: 46% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (13%) - pilR (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 36% Positives: 45% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - pilR (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 46% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (97%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 32% Positives: 42% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (97%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 37% E-Value: 0

Method

DB Source

Type

Publication

physical association

MXAN_1350 (97%) - MXAN_1680 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 39% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - pilR (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 29% Positives: 35% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (18%) - MXAN_7143 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 38% E-Value: 4.01e-61

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (97%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 32% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (18%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 39% E-Value: 2.13e-62

Method

DB Source

Type

Publication

physical association

phoR3 (16%) - MXAN_7143 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 36% E-Value: 8.66e-56

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (16%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 38% E-Value: 1.43e-58

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (15%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 35% E-Value: 2.52e-55

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

zraS (13%) - zraR (39%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 23% Positives: 35% E-Value: 3.76e-55

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

asgD (13%) - MXAN_7143 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 34% E-Value: 1.10e-50

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (13%) - MXAN_7143 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 35% E-Value: 6.87e-49

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

glnL (14%) - glnG (37%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 22% Positives: 35% E-Value: 4.76e-46

Method

DB Source

Type

Publication

physical association

Salinas P et al. (2003)

asgD (13%) - nla28 (37%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 34% E-Value: 1.87e-50

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (12%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 33% E-Value: 1.06e-49

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 35% E-Value: 2.61e-52

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (13%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 35% E-Value: 2.13e-50

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

difE (9%) - nla19 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 4.16e-50

Method

DB Source

Type

Publication

physical association

Lancero HL et al. (2005)

MXAN_6688 (10%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 4.76e-50

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 26% E-Value: 2.28e-48

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

nifL (10%) - nifA (30%) (Azotobacter vinelandii)

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 6.23e-38

Method

DB Source

Type

Publication

physical association

Lei S et al. (1999)

MXAN_2606 (18%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 26% E-Value: 6.06e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (18%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 26% E-Value: 3.55e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1672 (14%) - slr1529 (18%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 5.86e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_2606 (18%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 25% E-Value: 1.22e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (16%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 25% E-Value: 7.66e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (16%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 25% E-Value: 8.46e-19

Method

DB Source

Type

Publication

physical association

cph1 (12%) - slr1529 (18%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 3.01e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_7059 (14%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 4.35e-11

Method

DB Source

Type

Publication

physical association

MXAN_5314 (15%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 5.31e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR2 (14%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 2.73e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (16%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 1.54e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (16%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 1.71e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (14%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 8.77e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 1.50e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (13%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 9.69e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 7.42e-11

Method

DB Source

Type

Publication

physical association

pilS (13%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 1.60e-13

Method

DB Source

Type

Publication

physical association

pilS (13%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 7.93e-13

Method

DB Source

Type

Publication

physical association

phoR2 (14%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 5.49e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (18%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 3.00e-24

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (13%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 1.22e-09

Method

DB Source

Type

Publication

physical association

sdeK (13%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 6.08e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (12%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 3.02e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1353 (15%) - sll1905 (11%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 9.67e-19

Method

DB Source

Type

Publication

physical association

pleC (18%) - pleD (10%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 3.01e-16

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

MXAN_2606 (9%) - MXAN_2606 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 5.48e-22

Method

DB Source

Type

Publication

physical association

MXAN_6688 (10%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 1.35e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (18%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 18% E-Value: 3.79e-23

Method

DB Source

Type

Publication

physical association

MXAN_7398 (16%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 3.44e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (18%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 3.21e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (18%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 18% E-Value: 2.22e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1166 (18%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 1.22e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (18%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 5.48e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (18%) - MXAN_5313 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 2.22e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (18%) - MXAN_5313 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 1.30e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (12%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 6.08e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7142 (19%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 6.95e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (15%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 6.06e-17

Method

DB Source

Type

Publication

physical association

sll0798 (15%) - sll0797 (9%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 6.06e-17

Method

DB Source

Type

Publication

physical association

divJ (15%) - pleD (10%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 1.49e-15

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

MXAN_6688 (10%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 2.73e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (18%) - MXAN_5995 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 6.26e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5314 (15%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 4.81e-14

Method

DB Source

Type

Publication

physical association

MXAN_5314 (15%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 17% E-Value: 3.33e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 6.28e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (16%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 6.93e-17

Method

DB Source

Type

Publication

physical association

MXAN_2606 (18%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 1.59e-21

Method

DB Source

Type

Publication

physical association

phoR1 (18%) - phoP3 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 3.67e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (18%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 9.35e-22

Method

DB Source

Type

Publication

physical association

phoR1 (18%) - MXAN_1349 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 9.99e-24

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (18%) - MXAN_1349 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 1.70e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (16%) - MXAN_5995 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 8.75e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (16%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 7.65e-20

Method

DB Source

Type

Publication

physical association

MXAN_2785 (16%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 5.30e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (16%) - MXAN_5313 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 2.81e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (18%) - phoP1 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 2.81e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoQ (10%) - phoP (11%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 2.02e-12

Method	DB Source	Type	Publication
far western blotting		physical association	Chamnongpol S et al. (2000)
surface plasmon resonance		physical association	Castelli ME et al. (2003)

cpxA (14%) - cpxR (8%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 3.01e-16

Method	DB Source	Type	Publication
unspecified method		physical association	Nakayama S et al. (2003)

sll0474 (16%) - slr1400 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.14e-19

Method

DB Source

Type

Publication

physical association

slr1147 (13%) - sll0797 (9%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 2.16e-10

Method

DB Source

Type

Publication

physical association

slr1147 (13%) - slr1783 (9%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 8.48e-11

Method

DB Source

Type

Publication

physical association

sll0790 (14%) - sll0789 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.71e-15

Method

DB Source

Type

Publication

physical association

slr0210 (15%) - slr1909 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.76e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr0533 (15%) - sll0649 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.65e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

yycG (14%) - yycF (8%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.35e-20

Method	DB Source	Type	Publication
enzymatic study		physical association	Fukuchi K et al. (2000)

kdpD (14%) - A2VGV6 (8%) (Mycobacterium tuberculosis C - Mycobacterium tuberculosis)

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.77e-12

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Davey CA et al. (2002)

arcB (15%) - cheY (8%) (Escherichia coli O157:H7 - Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 4.21e-14

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Kato M et al. (1999)

phoQ (11%) - phoP (10%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 19% E-Value: 3.94e-12

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

MXAN_7059 (14%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 3.94e-12

Method

DB Source

Type

Publication

physical association

asgD (13%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 8.77e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 6.71e-12

Method

DB Source

Type

Publication

physical association

MXAN_7206 (8%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 6.50e-07

Method

DB Source

Type

Publication

physical association

pilS (13%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 7.17e-14

Method

DB Source

Type

Publication

physical association

MXAN_7059 (14%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 2.73e-13

Method

DB Source

Type

Publication

physical association

pilS (13%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 4.97e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 4.65e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (10%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.15e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR2 (14%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 2.47e-14

Method

DB Source

Type

Publication

physical association

phoR2 (14%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.71e-15

Method

DB Source

Type

Publication

physical association

MXAN_7398 (16%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.07e-17

Method

DB Source

Type

Publication

physical association

phoR3 (16%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 2.02e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR2 (14%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 7.17e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (14%) - MXAN_1680 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 19% E-Value: 1.50e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (13%) - MXAN_1680 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 2.73e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_1680 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 2.55e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (13%) - MXAN_5995 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 6.28e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (13%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 5.50e-10

Method

DB Source

Type

Publication

physical association

MXAN_3451 (13%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 2.31e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (13%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 1.60e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (18%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.39e-21

Method

DB Source

Type

Publication

physical association

MXAN_2606 (18%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.39e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (13%) - MXAN_5313 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 2.91e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (13%) - MXAN_5313 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 2.23e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (12%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 2.73e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (12%) - MXAN_1680 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.04e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (15%) - MXAN_5995 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 7.41e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

basS (12%) - basR (8%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.95e-11

Method	DB Source	Type	Publication
coimmunoprecipitation		physical association	Kato A et al. (2004)

sll1003 (14%) - slr1909 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 18% E-Value: 4.07e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1228 (15%) - sll1229 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 1.65e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1475 (14%) - slr1584 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 3.68e-14

Method

DB Source

Type

Publication

physical association

slr1759 (13%) - slr1760 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 1.11e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

CcaS (14%) - slr1584 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 3.68e-14

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation reaction	Hirose Y et al. (2008)

kinA (12%) - spo0F (8%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.11e-14

Method	DB Source	Type	Publication
genetic interference		physical association	Stephenson SJ et al. (2002)

prrB (15%) - prrA (7%) (Mycobacterium tuberculosis)

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 4.07e-13

Method	DB Source	Type	Publication
enzymatic study		direct interaction	Nowak E et al. (2006)

basS (13%) - basR (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 9.69e-11

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

kdpD (14%) - kdpE (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 10% Positives: 18% E-Value: 1.76e-16

Method	DB Source	Type	Publication
adenylate cyclase complementation		physical association	Luttmann D et al. (2009)
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)
enzymatic study		physical association	Heermann R et al. (2003)
protein kinase assay		physical association	Luttmann D et al. (2009)

torS (14%) - torR (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 10% Positives: 18% E-Value: 3.22e-14

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

envZ (12%) - ompR (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 3.68e-14

Method	DB Source	Type	Publication
electrophoretic mobility shift assay		physical association	Harlocker SL et al. (1995)
far western blotting		physical association	Cai SJ et al. (2002)
pull down		physical association	Cai SJ et al. (2002)

MXAN_6688 (10%) - MXAN_5995 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 1.40e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (10%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 1.22e-09

Method

DB Source

Type

Publication

physical association

asgD (13%) - phoP3 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.00e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (13%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 2.55e-11

Method

DB Source

Type

Publication

physical association

pilS (13%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 2.09e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.95e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (13%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.60e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (13%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 6.71e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (16%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 9.36e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5314 (15%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.22e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (16%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.95e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3606 (11%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.55e-08

Method

DB Source

Type

Publication

physical association

MXAN_7059 (14%) - MXAN_5212 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 3.56e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (16%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 9.36e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (14%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.00e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (16%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 1.95e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (12%) - MXAN_5212 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 2.47e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

regB (13%) - regA (8%) (Rhodobacter sphaeroides (strain ATCC 17023 / 241 / NCIB 8253 / DSM158))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 3.22e-10

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Potter CA et al. (2006)

slr2104 (12%) - slr1305 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 9% Positives: 18% E-Value: 5.31e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1905 (12%) - slr1305 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 9% Positives: 18% E-Value: 4.50e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

yedV (10%) - yedW (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 9% Positives: 16% E-Value: 2.09e-09

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

MXAN_7206 (8%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 5.88e-08

Method

DB Source

Type

Publication

physical association

MXAN_7206 (8%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 4.07e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 5.50e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (10%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 3.56e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_1680 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 2.23e-07

Method

DB Source

Type

Publication

physical association

asgD (13%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 2.23e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 1.71e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (10%) - MXAN_1349 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 3.81e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3606 (11%) - MXAN_5212 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 1.40e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (13%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 16% E-Value: 1.71e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4165 (11%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 6.08e-09

Method

DB Source

Type

Publication

physical association

MXAN_5996 (12%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 6.95e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0461 (8%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 2.39e-09

Method

DB Source

Type

Publication

physical association

difE (9%) - difD (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 2.23e-07

Method

DB Source

Type

Publication

physical association

Lancero HL et al. (2005)

MXAN_7206 (8%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.71e-07

Method

DB Source

Type

Publication

physical association