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The Microbial Protein Interaction Database

Interaction Evidences

MXAN_2606 - MXAN_6149 ( Myxococcus xanthus (strain DK 1622) )

Protein A	Protein B
Q1D948 Sensor protein MXAN_2606	Q1CZ93 DNA-binding response regulator, LuxR family MXAN_6149
CMR Search...	CMR Search...
GO MF: two-component sensor activity GO MF: ATP binding GO MF: two-component response regulator activity GO CC: membrane GO BP: regulation of transcription, DNA-dependent GO BP: peptidyl-histidine phosphorylation GO BP: two-component signal transduction system (p...	GO MF: transcription factor activity GO MF: sequence-specific DNA binding GO MF: two-component response regulator activity GO CC: intracellular GO BP: transcription GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...

List of evidences (44)

Experiments (1)

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Interologs (40)

MXAN_2606 (88%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 48% Positives: 64% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (88%) - fruA (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 42% Positives: 53% E-Value: 0

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7398 (5%) - MXAN_6149 (93%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 26% E-Value: 2.45e-59

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (5%) - MXAN_6149 (93%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 25% E-Value: 5.45e-59

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (4%) - MXAN_6149 (93%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 26% E-Value: 3.20e-59

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (4%) - MXAN_6149 (93%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 25% E-Value: 7.87e-58

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (4%) - MXAN_6149 (93%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 25% E-Value: 1.59e-58

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (13%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 3.34e-24

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

evgS (9%) - evgA (25%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 8.52e-16

Method	DB Source	Type	Publication
surface plasmon resonance		physical association	Perraud AL et al. (2000)
surface plasmon resonance		physical association	Tanabe H et al. (1998)

arcB (9%) - hnr (24%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 1.11e-11

Method	DB Source	Type	Publication
enzymatic study		physical association	Mika F et al. (2005)

bvgS (7%) - bvgA (27%) (Bordetella pertussis)

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 4.68e-14

Method	DB Source	Type	Publication
genetic interference		physical association	Merkel TJ et al. (2003)

slr1805 (7%) - sll1708 (28%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 1.96e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_7206 (7%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 8.24e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (6%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 2.32e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll0649 (5%) - sll1592 (29%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 4.83e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1414 (5%) - sll1592 (29%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 4.23e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_1350 (7%) - fruA (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 1.78e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr0210 (5%) - slr1909 (23%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 7.98e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_1350 (7%) - MXAN_0460 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 15% E-Value: 2.57e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (5%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 19% E-Value: 3.13e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.66e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (4%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 3.35e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (5%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 6.98e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (5%) - fruA (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.01e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (7%) - MXAN_0460 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 6.11e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (4%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 6.75e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (4%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 18% E-Value: 2.03e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (6%) - MXAN_0460 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 1.72e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

fixJ (22%) - fixJ (3%) (Rhizobium meliloti (Sinorhizobium meliloti))

Geometric mean of BLAST Identity: 9% Positives: 16% E-Value: 1.72e-08

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Gouet P et al. (1999)

asgD (4%) - fruA (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 5.18e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (4%) - fruA (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 2.10e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (4%) - fruA (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 2.74e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (5%) - MXAN_0460 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 2.32e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - MXAN_0460 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 1.23e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (4%) - fruA (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 1.72e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (4%) - fruA (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 5.18e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (4%) - MXAN_0460 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 11% E-Value: 7.47e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (16%) - MXAN_0460 (4%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 5.01e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR1 (4%) - MXAN_0460 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 11% E-Value: 8.83e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0461 (4%) - MXAN_0460 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 11% E-Value: 1.23e-06

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

Domain-Domain Interactions (3)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Response_reg
structural domain contact	3DID	predicted interaction	Response_reg	HisKA
structural domain contact	3DID	predicted interaction	Response_reg	GerE

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