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The Microbial Protein Interaction Database

Interaction Evidences

MXAN_7396 - MXAN_3450 ( Myxococcus xanthus (strain DK 1622) )

Protein A	Protein B
Q1CVS0 Response regulator/adenylate cyclase MXAN_7396	Q1D6S6 DNA-binding heavy metal response regulator MXAN_3450
CMR Search...	CMR Search...
GO MF: adenylate cyclase activity GO MF: two-component response regulator activity GO BP: intracellular signaling cascade GO BP: regulation of transcription, DNA-dependent GO BP: cyclic nucleotide biosynthetic process GO BP: two-component signal transduction system (p...	GO MF: DNA binding GO MF: two-component response regulator activity GO CC: intracellular GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...

List of evidences (78)

Experiments (1)

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

Interologs (75)

MXAN_7396 (94%) - MXAN_5212 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 55% Positives: 65% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (94%) - phoP2 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 54% Positives: 63% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (94%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 51% Positives: 63% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (94%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 36% Positives: 46% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (94%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 36% Positives: 46% E-Value: 0

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (94%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 43% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5212 (9%) - MXAN_3450 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 29% Positives: 33% E-Value: 3.87e-59

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (88%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 28% Positives: 34% E-Value: 2.42e-61

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (8%) - MXAN_3450 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 33% E-Value: 6.83e-60

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1680 (7%) - MXAN_3450 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 31% E-Value: 1.86e-61

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

yedW (33%) - yedW (9%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 7.63e-19

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoP (29%) - phoP (10%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 1.54e-15

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)
molecular sieving		physical association	Bachhawat P et al. (2007)
x-ray crystallography		physical association	Bachhawat P et al. (2007)

qseB (35%) - qseB (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 17% Positives: 25% E-Value: 2.80e-21

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

yedW (9%) - cusR (34%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 17% Positives: 27% E-Value: 2.15e-17

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_6149 (10%) - phoP2 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 25% E-Value: 9.03e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (9%) - MXAN_1680 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 25% E-Value: 2.90e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (9%) - MXAN_5212 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 24% E-Value: 8.44e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (10%) - phoP2 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 24% E-Value: 8.44e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll0797 (31%) - sll0797 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 2.30e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

phoP (32%) - phoP (8%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 5.29e-20

Method	DB Source	Type	Publication
genetic interference		physical association	Chen Y et al. (2003)
x-ray crystallography		physical association	Chen Y et al. (2003)

cusR (7%) - yedW (33%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 16% Positives: 25% E-Value: 7.39e-18

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

cusR (34%) - cusR (7%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 16% Positives: 24% E-Value: 2.08e-16

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_2606 (8%) - phoP2 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 23% E-Value: 4.05e-16

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

cpxR (29%) - cpxR (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 4.33e-14

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

ompR (8%) - phoB (28%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 3.00e-15

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

kdpE (8%) - creB (29%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 22% E-Value: 9.66e-14

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

kdpE (8%) - rstA (27%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 2.90e-14

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_2606 (8%) - MXAN_5995 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 2.90e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (8%) - MXAN_1349 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 5.12e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (7%) - MXAN_1680 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 3.79e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (8%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 7.15e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (7%) - MXAN_5313 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 8.44e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

ompR (26%) - ompR (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 3.32e-14

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoB (7%) - ompR (26%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 8.73e-15

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoB (28%) - phoB (7%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 7.90e-16

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

creB (29%) - creB (7%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 5.66e-14

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

creB (7%) - kdpE (30%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 6.05e-16

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoP2 (31%) - phoP2 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 1.82e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (28%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 3.32e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (7%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 1.95e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (6%) - MXAN_5313 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 6.05e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7024 (6%) - MXAN_5212 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 5.12e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

rstA (6%) - kdpE (30%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 1.65e-13

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

baeR (29%) - baeR (6%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 7.39e-14

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_4645 (6%) - MXAN_5995 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 9.34e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

torR (19%) - torR (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 2.30e-07

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

arcA (23%) - arcA (7%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 2.15e-09

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

rstA (27%) - rstA (6%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 4.64e-12

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_6149 (10%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 7.92e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr2100 (8%) - slr2098 (14%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 3.11e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_5995 (9%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 6.06e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (9%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.26e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_6149 (10%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 3.21e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (9%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 7.92e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (9%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 1.65e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1349 (9%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 5.48e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (9%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.22e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (9%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 2.54e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (8%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 7.16e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5212 (9%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 15% E-Value: 8.18e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (10%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 9.67e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr1305 (7%) - slr2104 (13%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 4.96e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

glnG (13%) - glnG (7%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.26e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Salinas P et al. (2003)

MXAN_2606 (14%) - MXAN_2606 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 3.55e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (8%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 1.44e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (7%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 1.60e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (8%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 4.64e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (7%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 1.26e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (7%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.65e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (7%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 14% E-Value: 6.70e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (7%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 3.32e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (7%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 6.48e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (6%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 1.14e-06

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_4645 (6%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 4.64e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_4645 (6%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 2.30e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Domain-Domain Interactions (2)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Response_reg
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Trans_reg_C

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