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The Microbial Protein Interaction Database

Interaction Evidences

MXAN_3450 - MXAN_1679 ( Myxococcus xanthus (strain DK 1622) )

Protein A	Protein B
Q1D6S6 DNA-binding heavy metal response regulator MXAN_3450	Q1DBP2 Sensor protein MXAN_1679
CMR Search...	CMR Search...
GO MF: DNA binding GO MF: two-component response regulator activity GO CC: intracellular GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...	GO MF: two-component sensor activity GO MF: ATP binding GO CC: integral to membrane GO BP: peptidyl-histidine phosphorylation GO BP: two-component signal transduction system (p...

List of evidences (49)

Experiments (1)

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Interologs (47)

phoP2 (31%) - MXAN_1679 (95%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 54% Positives: 64% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (88%) - MXAN_5211 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 39% Positives: 50% E-Value: 1.45e-58

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (88%) - MXAN_3451 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 39% Positives: 49% E-Value: 6.50e-59

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (88%) - phoR2 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 37% Positives: 45% E-Value: 9.38e-58

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_3450 (88%) - phoR1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 37% Positives: 48% E-Value: 2.82e-58

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_1679 (95%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 37% Positives: 47% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (14%) - MXAN_1679 (95%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 36% Positives: 47% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - MXAN_1679 (95%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 41% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (13%) - MXAN_1679 (95%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 43% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

prrA (35%) - prrB (19%) (Mycobacterium tuberculosis)

Geometric mean of BLAST Identity: 26% Positives: 38% E-Value: 1.05e-16

Method	DB Source	Type	Publication
enzymatic study		direct interaction	Nowak E et al. (2006)

sll0649 (32%) - slr0533 (19%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 25% Positives: 38% E-Value: 8.59e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_5313 (34%) - phoR3 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 34% E-Value: 8.03e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr1584 (33%) - sll1475 (15%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 23% Positives: 37% E-Value: 2.50e-18

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

slr1584 (33%) - CcaS (15%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 23% Positives: 37% E-Value: 2.50e-18

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation reaction	Hirose Y et al. (2008)

yedW (33%) - yedV (16%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 23% Positives: 38% E-Value: 2.11e-17

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

basR (30%) - basS (18%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 23% Positives: 38% E-Value: 1.62e-17

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

phoP2 (31%) - MXAN_5211 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 35% E-Value: 8.59e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (31%) - phoR3 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 33% E-Value: 1.73e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (33%) - MXAN_5211 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 36% E-Value: 1.73e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (31%) - MXAN_3451 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 34% E-Value: 3.86e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (34%) - phoR1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 35% E-Value: 7.77e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

basR (29%) - basS (17%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 22% Positives: 37% E-Value: 9.18e-17

Method	DB Source	Type	Publication
coimmunoprecipitation		physical association	Kato A et al. (2004)

creB (29%) - creC (17%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 22% Positives: 34% E-Value: 2.34e-12

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

phoP2 (31%) - phoR2 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 31% E-Value: 5.57e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP3 (33%) - phoR1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 34% E-Value: 4.26e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (31%) - phoR1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 33% E-Value: 1.67e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_4164 (28%) - MXAN_5211 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 34% E-Value: 1.52e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP1 (31%) - phoR1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 34% E-Value: 1.47e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (28%) - MXAN_4165 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 33% E-Value: 1.98e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

ompR (26%) - envZ (15%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 20% Positives: 34% E-Value: 1.02e-11

Method	DB Source	Type	Publication
electrophoretic mobility shift assay		physical association	Harlocker SL et al. (1995)
far western blotting		physical association	Cai SJ et al. (2002)
pull down		physical association	Cai SJ et al. (2002)

MXAN_1349 (27%) - phoR1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 33% E-Value: 2.12e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (15%) - MXAN_5211 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 25% E-Value: 5.05e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (14%) - phoR3 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 24% E-Value: 1.52e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (14%) - MXAN_1166 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 1.12e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (14%) - MXAN_5211 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 7.54e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (13%) - MXAN_5211 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 22% E-Value: 3.06e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (14%) - phoR2 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 4.88e-06

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (13%) - phoR3 (18%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 21% E-Value: 6.16e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (13%) - MXAN_5211 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 9.84e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (15%) - phoR1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 9.84e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (13%) - MXAN_3451 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 4.42e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (14%) - MXAN_3451 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 3.38e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_5211 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 1.52e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (14%) - phoR1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 2.96e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - phoR2 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 1.98e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - phoR1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 5.96e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (14%) - phoR1 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 1.47e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Domain-Domain Interactions (1)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID	predicted interaction	Response_reg	HisKA

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