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The Microbial Protein Interaction Database

Interaction Evidences

MXAN_3450 - MXAN_3450 ( Myxococcus xanthus (strain DK 1622) )

Protein A	Protein B
Q1D6S6 DNA-binding heavy metal response regulator MXAN_3450	Q1D6S6 DNA-binding heavy metal response regulator MXAN_3450
CMR Search...	CMR Search...
GO MF: DNA binding GO MF: two-component response regulator activity GO CC: intracellular GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...	GO MF: DNA binding GO MF: two-component response regulator activity GO CC: intracellular GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...

List of evidences (83)

Experiments (1)

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Interologs (79)

MXAN_1680 (33%) - MXAN_3450 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 54% Positives: 64% E-Value: 1.71e-62

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (88%) - MXAN_1680 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 54% Positives: 64% E-Value: 1.71e-62

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5212 (33%) - MXAN_3450 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 54% Positives: 63% E-Value: 4.97e-66

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (88%) - MXAN_5212 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 54% Positives: 63% E-Value: 4.97e-66

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

qseB (35%) - qseB (35%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 35% Positives: 49% E-Value: 4.70e-28

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_3450 (88%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 45% E-Value: 7.43e-58

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (14%) - MXAN_3450 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 45% E-Value: 7.43e-58

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_3450 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 45% E-Value: 1.50e-58

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (88%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 45% E-Value: 1.50e-58

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cusR (34%) - cusR (34%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 34% Positives: 46% E-Value: 2.41e-24

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_3450 (88%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 34% Positives: 40% E-Value: 3.02e-59

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (13%) - MXAN_3450 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 34% Positives: 40% E-Value: 3.02e-59

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

pilR (13%) - MXAN_3450 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 34% Positives: 42% E-Value: 9.71e-58

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (88%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 34% Positives: 42% E-Value: 9.71e-58

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

yedW (33%) - yedW (33%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 33% Positives: 50% E-Value: 3.05e-27

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

cusR (34%) - yedW (33%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 33% Positives: 48% E-Value: 8.57e-26

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

yedW (33%) - cusR (34%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 33% Positives: 48% E-Value: 8.57e-26

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoP (32%) - phoP (32%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 32% Positives: 50% E-Value: 2.85e-25

Method	DB Source	Type	Publication
genetic interference		physical association	Chen Y et al. (2003)
x-ray crystallography		physical association	Chen Y et al. (2003)

MXAN_5313 (34%) - phoP2 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 32% Positives: 45% E-Value: 2.33e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (31%) - MXAN_5313 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 32% Positives: 45% E-Value: 2.33e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll0797 (31%) - sll0797 (31%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 31% Positives: 44% E-Value: 3.05e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

phoP2 (31%) - phoP2 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 31% Positives: 43% E-Value: 5.03e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (28%) - MXAN_1680 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 44% E-Value: 1.79e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (33%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 44% E-Value: 1.79e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cpxR (29%) - cpxR (29%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 29% Positives: 46% E-Value: 2.19e-17

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

creB (29%) - creB (29%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 29% Positives: 41% E-Value: 1.42e-16

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

kdpE (30%) - creB (29%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 29% Positives: 44% E-Value: 1.51e-18

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

creB (29%) - kdpE (30%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 29% Positives: 44% E-Value: 1.51e-18

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoP (29%) - phoP (29%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 29% Positives: 47% E-Value: 1.91e-21

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)
molecular sieving		physical association	Bachhawat P et al. (2007)
x-ray crystallography		physical association	Bachhawat P et al. (2007)

rstA (27%) - kdpE (30%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 29% Positives: 44% E-Value: 4.56e-19

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

kdpE (30%) - rstA (27%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 29% Positives: 44% E-Value: 4.56e-19

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

baeR (29%) - baeR (29%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 29% Positives: 44% E-Value: 8.31e-17

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoB (28%) - phoB (28%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 28% Positives: 42% E-Value: 1.16e-18

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_4164 (28%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 28% Positives: 42% E-Value: 1.57e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoB (28%) - ompR (26%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 27% Positives: 43% E-Value: 1.28e-17

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

ompR (26%) - phoB (28%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 27% Positives: 43% E-Value: 1.28e-17

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

rstA (27%) - rstA (27%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 27% Positives: 42% E-Value: 1.28e-17

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

ompR (26%) - ompR (26%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 26% Positives: 44% E-Value: 1.42e-16

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

arcA (23%) - arcA (23%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 23% Positives: 37% E-Value: 1.29e-09

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoP2 (31%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 31% E-Value: 4.41e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (14%) - phoP2 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 31% E-Value: 4.41e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1680 (33%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 30% E-Value: 1.16e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (13%) - MXAN_1680 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 30% E-Value: 1.16e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_5995 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 31% E-Value: 6.37e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (31%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 31% E-Value: 6.37e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5212 (33%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 29% E-Value: 1.05e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - MXAN_5212 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 29% E-Value: 1.05e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (34%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 31% E-Value: 2.67e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (13%) - MXAN_5313 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 31% E-Value: 2.67e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

fixJ (20%) - fixJ (20%) (Rhizobium meliloti (Sinorhizobium meliloti))

Geometric mean of BLAST Identity: 20% Positives: 34% E-Value: 5.97e-07

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Gouet P et al. (1999)

MXAN_2606 (14%) - MXAN_5995 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 3.16e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (31%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 3.16e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (31%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 28% E-Value: 1.79e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - phoP2 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 28% E-Value: 1.79e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (13%) - MXAN_5995 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 29% E-Value: 4.13e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (31%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 29% E-Value: 4.13e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (28%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 7.79e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (28%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 1.57e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 1.57e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (14%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 7.79e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

torR (19%) - torR (19%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 19% Positives: 31% E-Value: 5.40e-08

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_1349 (27%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 5.58e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (14%) - MXAN_1349 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 32% E-Value: 5.58e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (28%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 28% E-Value: 3.16e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 28% E-Value: 3.16e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (15%) - MXAN_0460 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 22% E-Value: 1.74e-06

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (14%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 3.87e-06

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 7.80e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 3.17e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (13%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 3.17e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 1.57e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (14%) - MXAN_2785 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 7.80e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

glnG (13%) - glnG (13%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 8.33e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Salinas P et al. (2003)

MXAN_7396 (13%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 1.57e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (14%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 1.57e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (13%) - MXAN_2606 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 5.05e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (13%) - MXAN_7396 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 2.05e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (13%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 2.05e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (14%) - pilR (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 5.05e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Domain-Domain Interactions (3)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Response_reg
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Trans_reg_C
structural domain contact	3DID	predicted interaction	Trans_reg_C	Trans_reg_C

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