The Microbial Protein Interaction Database

physical association

MXAN_2606 (88%) - MXAN_1349 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 54% Positives: 65% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (88%) - MXAN_5995 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 51% Positives: 63% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (88%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 50% Positives: 62% E-Value: 0

Method

DB Source

Type

Publication

physical association

MXAN_2606 (88%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 39% Positives: 49% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (17%) - MXAN_2606 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 39% Positives: 49% E-Value: 0

Method

DB Source

Type

Publication

physical association

MXAN_2606 (88%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 38% Positives: 46% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (88%) - cheB1 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 38% Positives: 45% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (88%) - MXAN_4645 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 37% Positives: 47% E-Value: 0

Method

DB Source

Type

Publication

physical association

MXAN_2606 (88%) - MXAN_7363 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 37% Positives: 43% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (88%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 36% Positives: 43% E-Value: 0

Method

DB Source

Type

Publication

physical association

MXAN_2606 (88%) - frzS (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 46% E-Value: 0

Method

DB Source

Type

Publication

physical association

MXAN_2606 (88%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 35% Positives: 43% E-Value: 0

Method

DB Source

Type

Publication

physical association

MXAN_2606 (88%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 33% Positives: 44% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (13%) - MXAN_4164 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 33% Positives: 41% E-Value: 1.50e-71

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (7%) - MXAN_4164 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 31% E-Value: 3.71e-62

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (5%) - MXAN_4164 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 25% E-Value: 1.41e-61

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (4%) - MXAN_4164 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 25% E-Value: 1.84e-61

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - MXAN_4164 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 25% E-Value: 7.48e-63

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (88%) - MXAN_4164 (5%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 25% E-Value: 8.84e-64

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (13%) - MXAN_5995 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 29% E-Value: 4.15e-25

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (13%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 29% E-Value: 4.74e-25

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (4%) - MXAN_4164 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 25% E-Value: 3.84e-63

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (4%) - MXAN_4164 (88%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 21% E-Value: 4.54e-60

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (9%) - MXAN_5313 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 27% E-Value: 1.21e-28

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr2104 (12%) - slr1305 (20%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 16% Positives: 24% E-Value: 3.63e-25

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_7206 (7%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 4.30e-18

Method

DB Source

Type

Publication

physical association

pilS (7%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 22% E-Value: 3.52e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (13%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 9.25e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (13%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 9.89e-23

Method

DB Source

Type

Publication

physical association

pilS (7%) - MXAN_5313 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 22% E-Value: 4.29e-26

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr0533 (6%) - sll0649 (34%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 6.19e-25

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

phoB (36%) - phoB (5%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 2.87e-26

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_7206 (7%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 1.17e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (7%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 9.57e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (7%) - MXAN_1680 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 7.59e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (7%) - MXAN_1680 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 3.89e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (13%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 7.32e-22

Method

DB Source

Type

Publication

physical association

MXAN_2785 (13%) - MXAN_4645 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 9.89e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (15%) - MXAN_2785 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 4.44e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (13%) - MXAN_7363 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 5.25e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1229 (10%) - sll1228 (17%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 2.79e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1475 (5%) - slr1584 (32%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 9.57e-18

Method

DB Source

Type

Publication

physical association

sll1353 (10%) - sll1905 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 2.79e-17

Method

DB Source

Type

Publication

physical association

slr1759 (10%) - slr1760 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 9.91e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr2098 (9%) - slr2100 (19%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 4.60e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

CcaS (5%) - slr1584 (32%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 9.57e-18

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation reaction	Hirose Y et al. (2008)

yycG (4%) - yycF (35%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 2.97e-23

Method	DB Source	Type	Publication
enzymatic study		physical association	Fukuchi K et al. (2000)

phoP (36%) - phoP (5%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 9.55e-26

Method	DB Source	Type	Publication
genetic interference		physical association	Chen Y et al. (2003)
x-ray crystallography		physical association	Chen Y et al. (2003)

cpxR (31%) - cpxR (5%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 18% E-Value: 1.06e-20

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoB (5%) - ompR (31%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 1.69e-22

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

ompR (5%) - phoB (36%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 8.94e-24

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

rstA (6%) - kdpE (31%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 1.38e-16

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

rstA (28%) - rstA (6%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 5.08e-15

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

baeR (38%) - baeR (5%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 1.74e-27

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

yedW (5%) - cusR (30%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 4.30e-18

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_7398 (5%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 1.63e-17

Method

DB Source

Type

Publication

physical association

phoP2 (33%) - phoP2 (5%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 18% E-Value: 3.64e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (7%) - MXAN_1680 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 9.27e-13

Method

DB Source

Type

Publication

physical association

MXAN_7363 (9%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 5.61e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (5%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 1.53e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (5%) - MXAN_5313 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 18% E-Value: 4.44e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (6%) - MXAN_5995 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 2.88e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1228 (9%) - sll1229 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 2.60e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1759 (10%) - slr1594 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 1.87e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll0790 (5%) - sll0789 (30%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 9.57e-18

Method

DB Source

Type

Publication

physical association

slr0210 (5%) - slr1909 (28%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 1.02e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

yedW (28%) - yedW (5%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 1.34e-19

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

ompR (31%) - ompR (5%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 5.25e-20

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

arcB (9%) - cheY (15%) (Escherichia coli O157:H7 - Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 4.16e-13

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Kato M et al. (1999)

creB (33%) - creB (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 4.29e-22

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

kdpE (5%) - creB (33%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 1.99e-23

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

torS (5%) - torR (26%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 6.64e-15

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

envZ (5%) - ompR (31%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 7.84e-16

Method	DB Source	Type	Publication
electrophoretic mobility shift assay		physical association	Harlocker SL et al. (1995)
far western blotting		physical association	Cai SJ et al. (2002)
pull down		physical association	Cai SJ et al. (2002)

MXAN_6688 (5%) - MXAN_5995 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 2.06e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (4%) - phoP3 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 5.25e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (4%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 2.13e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 8.66e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (4%) - phoP3 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 17% E-Value: 6.21e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (4%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 16% E-Value: 6.21e-17

Method

DB Source

Type

Publication

physical association

MXAN_3451 (4%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 1.75e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - MXAN_1349 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 1.53e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (4%) - MXAN_1349 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 16% E-Value: 1.09e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (9%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 2.52e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (4%) - MXAN_5313 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 17% E-Value: 7.57e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (4%) - MXAN_5313 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 5.80e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (4%) - phoP1 (32%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 17% E-Value: 2.36e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cpxA (4%) - cpxR (31%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 5.43e-17

Method	DB Source	Type	Publication
unspecified method		physical association	Nakayama S et al. (2003)

sll0798 (5%) - sll0797 (25%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 21% E-Value: 7.10e-13

Method

DB Source

Type

Publication

physical association

slr1147 (5%) - sll0797 (25%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.48e-10

Method

DB Source

Type

Publication

physical association

slr1147 (5%) - slr1783 (22%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 15% E-Value: 1.58e-12

Method

DB Source

Type

Publication

physical association

sll1905 (6%) - slr1305 (20%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 15% E-Value: 5.25e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

arcA (30%) - arcA (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 4.30e-18

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

arcB (9%) - hnr (13%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 3.52e-12

Method	DB Source	Type	Publication
enzymatic study		physical association	Mika F et al. (2005)

creB (4%) - kdpE (31%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 2.70e-16

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

kdpD (4%) - kdpE (31%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.48e-14

Method	DB Source	Type	Publication
adenylate cyclase complementation		physical association	Luttmann D et al. (2009)
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)
enzymatic study		physical association	Heermann R et al. (2003)
protein kinase assay		physical association	Luttmann D et al. (2009)

phoP (30%) - phoP (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 4.02e-16

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)
molecular sieving		physical association	Bachhawat P et al. (2007)
x-ray crystallography		physical association	Bachhawat P et al. (2007)

kdpE (5%) - rstA (28%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 4.60e-16

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

qseB (28%) - qseB (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 5.81e-15

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

cusR (4%) - yedW (28%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 19% E-Value: 6.21e-17

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

cusR (30%) - cusR (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 19% E-Value: 2.00e-15

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

pleC (7%) - pleD (18%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.48e-14

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

MXAN_7206 (7%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 2.44e-13

Method

DB Source

Type

Publication

physical association

MXAN_7206 (7%) - cheB1 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 1.17e-11

Method

DB Source

Type

Publication

physical association

pilS (7%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 1.87e-13

Method

DB Source

Type

Publication

physical association

pilS (7%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 2.00e-15

Method

DB Source

Type

Publication

physical association

pilS (7%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 1.48e-14

Method

DB Source

Type

Publication

physical association

MXAN_7396 (4%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 5.81e-15

Method

DB Source

Type

Publication

physical association

MXAN_3450 (29%) - MXAN_3450 (4%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 7.59e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (7%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.02e-15

Method

DB Source

Type

Publication

physical association

MXAN_1350 (7%) - cheB1 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 15% E-Value: 4.92e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7143 (4%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 9.91e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (4%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 5.25e-16

Method

DB Source

Type

Publication

physical association

MXAN_5211 (4%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 15% E-Value: 5.25e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (4%) - MXAN_5995 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 8.11e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (4%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.21e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (4%) - MXAN_1680 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 6.01e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (4%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 15% E-Value: 1.69e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1166 (7%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 16% E-Value: 1.58e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (4%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 4.76e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (4%) - MXAN_5995 (30%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.13e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (4%) - MXAN_5212 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 5.81e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (4%) - MXAN_5212 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 7.59e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (5%) - MXAN_1680 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 2.21e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (4%) - MXAN_5313 (35%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 4.15e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (4%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 2.88e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (4%) - phoP2 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.06e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll0797 (25%) - sll0797 (4%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 1.58e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1393 (5%) - slr1037 (18%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 14% E-Value: 3.89e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

torR (26%) - torR (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 2.88e-14

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

glnL (7%) - glnG (14%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 5.44e-13

Method

DB Source

Type

Publication

physical association

Salinas P et al. (2003)

MXAN_7206 (7%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.81e-12

Method

DB Source

Type

Publication

physical association

MXAN_5211 (4%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 1.43e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (7%) - frzS (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 4.76e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (7%) - MXAN_0460 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 9.60e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (7%) - MXAN_0460 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 4.03e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (4%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 9.27e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (4%) - MXAN_1680 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 7.35e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (4%) - MXAN_1680 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 14% E-Value: 1.13e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (7%) - MXAN_4645 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 2.44e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (7%) - MXAN_4645 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.02e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1349 (5%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 14% E-Value: 7.84e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (7%) - MXAN_5889 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 7.35e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (7%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 1.10e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5212 (4%) - MXAN_3450 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 2.14e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (7%) - MXAN_7363 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 1.30e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (7%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 2.36e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

bvgS (7%) - bvgA (12%) (Bordetella pertussis)

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 7.86e-08

Method	DB Source	Type	Publication
genetic interference		physical association	Merkel TJ et al. (2003)

sll0474 (5%) - slr1400 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 4.92e-14

Method

DB Source

Type

Publication

physical association

slr2100 (5%) - slr2098 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 2.98e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

pleC (7%) - divK (13%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 9% Positives: 17% E-Value: 3.77e-10

Method

DB Source

Type

Publication

dephosphorylation

phosphorylation

MXAN_6688 (5%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 4.60e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 4.92e-14

Method

DB Source

Type

Publication

physical association

MXAN_5995 (5%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 5.81e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (4%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 1.13e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (4%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 1.21e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 3.64e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (4%) - cheB1 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 5.82e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - cheB1 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 2.36e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP3 (5%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 4.45e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (4%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 1.58e-12

Method

DB Source

Type

Publication

physical association

MXAN_7398 (5%) - cheB1 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 4.45e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (5%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 1.93e-10

Method

DB Source

Type

Publication

physical association

phoP2 (5%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 2.07e-12

Method

DB Source

Type

Publication

physical association

phoP2 (5%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 1.53e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (7%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 1.87e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (7%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 1.53e-11

Method

DB Source

Type

Publication

physical association

MXAN_1350 (7%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 7.85e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (4%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 9.92e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (4%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 2.53e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (4%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 2.70e-12

Method

DB Source

Type

Publication

physical association

MXAN_7398 (5%) - MXAN_4645 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 9.27e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (5%) - MXAN_4645 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 5.81e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (5%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 2.61e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (5%) - MXAN_7363 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 4.92e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (5%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 4.30e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (5%) - MXAN_4645 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 8.67e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (5%) - MXAN_7363 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 12% E-Value: 4.60e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (6%) - MXAN_0460 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 2.70e-08

Method

DB Source

Type

Publication

physical association

TP_0519 (14%) - TP_0519 (4%) (Treponema pallidum)

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.25e-09

Method

DB Source

Type

Publication

two hybrid array

physical association

Titz B et al. (2008)

sphS (4%) - slr1594 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 7.60e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1305 (4%) - slr2104 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 5.26e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1305 (4%) - sll1905 (16%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 3.77e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll0649 (5%) - sll1592 (13%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 9.27e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1414 (5%) - sll1592 (13%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 8.12e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

kinA (6%) - spo0F (13%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 8% Positives: 15% E-Value: 2.44e-09

Method	DB Source	Type	Publication
genetic interference		physical association	Stephenson SJ et al. (2002)

zraS (5%) - zraR (14%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 8% Positives: 15% E-Value: 1.53e-11

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

glnG (14%) - glnG (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 4.45e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Salinas P et al. (2003)

divJ (4%) - pleD (18%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 4.76e-13

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

MXAN_7143 (4%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 5.27e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (4%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 2.98e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (4%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 11% E-Value: 2.79e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (4%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 11% E-Value: 2.98e-11

Method

DB Source

Type

Publication

physical association

asgD (4%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 2.21e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (4%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 11% E-Value: 2.21e-10

Method

DB Source

Type

Publication

physical association

asgD (4%) - cheB1 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.43e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

nla28 (4%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 2.53e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (4%) - nla28 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 1.39e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - frzS (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 2.28e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (4%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 1.17e-11

Method

DB Source

Type

Publication

physical association

MXAN_7398 (5%) - MXAN_0460 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 3.65e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - MXAN_0460 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 1.93e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (4%) - asgD (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.81e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (4%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.93e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (4%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.43e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (5%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 4.45e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (4%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 3.52e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (4%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 2.61e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (4%) - MXAN_0460 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 11% E-Value: 1.39e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (4%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 2.00e-11

Method

DB Source

Type

Publication

physical association

MXAN_7396 (4%) - MXAN_4645 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 1.21e-12

Method

DB Source

Type

Publication

physical association

MXAN_7143 (4%) - MXAN_4645 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 5.63e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (4%) - MXAN_4645 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 2.98e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (5%) - MXAN_5889 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 2.79e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - MXAN_5889 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 1.48e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (4%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 5.44e-09

Method

DB Source

Type

Publication

physical association

asgD (4%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.34e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 2.21e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (4%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 11% E-Value: 1.58e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (4%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.21e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (4%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 7.11e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5212 (4%) - MXAN_7396 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 3.30e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6688 (5%) - MXAN_7363 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 2.61e-11

Method

DB Source

Type

Publication

physical association

phoR1 (4%) - MXAN_7363 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 11% E-Value: 1.87e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (5%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 2.61e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (5%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 6.65e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (5%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 2.14e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (4%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 2.79e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (5%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 1.34e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (4%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 3.65e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5212 (4%) - MXAN_7024 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 3.19e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (4%) - MXAN_2606 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 6.01e-12

Method

DB Source

Type

Publication

physical association

cheY (3%) - HP_0392 (17%) (Helicobacter pylori (Campylobacter pylori))

Geometric mean of BLAST Identity: 7% Positives: 13% E-Value: 1.13e-10

Method

DB Source

Type

Publication

physical association

Rain JC et al. (2001)

HP_0392 (3%) - cheY (15%) (Helicobacter pylori (Campylobacter pylori))

Geometric mean of BLAST Identity: 7% Positives: 13% E-Value: 2.70e-08

Method

DB Source

Type

Publication

physical association

Rain JC et al. (2001)

cheY (3%) - cheB (15%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.94e-06

Method	DB Source	Type	Publication
unspecified method		physical association	Ninfa EG et al. (1991)

slr1594 (16%) - slr1594 (3%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 9.60e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr2024 (14%) - slr2024 (4%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 1.64e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

cheY (3%) - arcB (16%) (Escherichia coli O157:H7 - Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 3.90e-07

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Kato M et al. (1999)

divJ (4%) - divK (13%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 1.21e-08

Method

DB Source

Type

Publication

protein kinase assay

phosphorylation

Paul R et al. (2008)

MXAN_5211 (4%) - MXAN_0460 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.17e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (14%) - MXAN_0460 (4%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 7.86e-08

Method

DB Source

Type

Publication

physical association

MXAN_7396 (4%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 13% E-Value: 9.28e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (4%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 2.29e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (4%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 10% E-Value: 2.29e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (4%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 1.21e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (4%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 13% E-Value: 1.93e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (4%) - pilR (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 7.60e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (4%) - MXAN_4645 (16%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 2.98e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (4%) - MXAN_2785 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 10% E-Value: 1.34e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7143 (4%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.30e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (4%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 6.88e-08

Method

DB Source

Type

Publication

physical association

MXAN_5211 (4%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 10% E-Value: 6.88e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (4%) - MXAN_6296 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 4.61e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0461 (4%) - MXAN_0460 (14%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.94e-06

Method

DB Source

Type

Publication

physical association