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The Microbial Protein Interaction Database

Interaction Evidences

MXAN_5995 - MXAN_6296 ( Myxococcus xanthus (strain DK 1622) )

Protein A	Protein B
Q1CZP3 DNA-binding reponse regulator MXAN_5995	Q1CYV2 Response regulator MXAN_6296
CMR Search...	CMR Search...
GO MF: DNA binding GO MF: two-component response regulator activity GO CC: intracellular GO BP: transcription GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...	GO MF: two-component response regulator activity GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...

List of evidences (62)

Experiments (1)

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Interologs (59)

MXAN_3450 (35%) - MXAN_6296 (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 59% Positives: 68% E-Value: 1.23e-49

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (100%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 49% Positives: 62% E-Value: 3.43e-68

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (100%) - MXAN_4645 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 48% Positives: 59% E-Value: 5.12e-68

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (23%) - MXAN_6296 (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 48% Positives: 58% E-Value: 7.20e-46

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7396 (23%) - MXAN_6296 (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 47% Positives: 55% E-Value: 2.24e-43

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (22%) - MXAN_6296 (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 47% Positives: 59% E-Value: 1.55e-40

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7143 (19%) - MXAN_6296 (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 44% Positives: 55% E-Value: 4.83e-42

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

frzS (17%) - MXAN_6296 (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 41% Positives: 53% E-Value: 1.19e-40

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (16%) - MXAN_6296 (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 40% Positives: 50% E-Value: 6.30e-42

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP (28%) - phoP (36%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 32% Positives: 50% E-Value: 1.28e-18

Method	DB Source	Type	Publication
genetic interference		physical association	Chen Y et al. (2003)
x-ray crystallography		physical association	Chen Y et al. (2003)

ompR (38%) - phoB (25%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 31% Positives: 48% E-Value: 2.76e-17

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoB (25%) - phoB (37%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 31% Positives: 47% E-Value: 7.25e-18

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

cpxR (27%) - cpxR (34%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 30% Positives: 48% E-Value: 2.67e-16

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoP2 (35%) - MXAN_7143 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 48% E-Value: 8.29e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1349 (39%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 46% E-Value: 1.28e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (28%) - MXAN_4164 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 47% E-Value: 1.79e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (32%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 46% E-Value: 5.38e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (38%) - MXAN_4645 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 43% E-Value: 2.85e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

creB (34%) - kdpE (25%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 29% Positives: 43% E-Value: 1.51e-15

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

baeR (25%) - baeR (33%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 29% Positives: 48% E-Value: 6.14e-17

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_3450 (35%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 29% Positives: 43% E-Value: 5.94e-16

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoP2 (35%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 29% Positives: 44% E-Value: 7.25e-18

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

rstA (31%) - kdpE (25%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 28% Positives: 42% E-Value: 5.38e-13

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_4164 (33%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 28% Positives: 44% E-Value: 2.26e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

arcA (23%) - arcA (31%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 27% Positives: 45% E-Value: 4.12e-13

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

MXAN_2606 (23%) - MXAN_5995 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 40% E-Value: 2.76e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1592 (23%) - sll0649 (28%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 25% Positives: 42% E-Value: 1.09e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_7396 (23%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 37% E-Value: 8.59e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (23%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 38% E-Value: 2.76e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (22%) - MXAN_7143 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 40% E-Value: 8.60e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (24%) - MXAN_2606 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 36% E-Value: 3.49e-12

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

pilR (18%) - MXAN_5995 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 37% E-Value: 2.67e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1905 (20%) - slr1305 (26%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 23% Positives: 33% E-Value: 1.16e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

glnG (27%) - glnG (19%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 23% Positives: 34% E-Value: 5.75e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Salinas P et al. (2003)

asgD (22%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 37% E-Value: 7.52e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (23%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 35% E-Value: 1.09e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (17%) - MXAN_5995 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 36% E-Value: 9.82e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7396 (23%) - MXAN_4645 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 33% E-Value: 1.62e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (23%) - MXAN_4645 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 34% E-Value: 5.20e-12

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (23%) - MXAN_1349 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 37% E-Value: 1.20e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr1305 (19%) - sll1905 (25%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 22% Positives: 37% E-Value: 8.03e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

asgD (22%) - MXAN_4645 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 35% E-Value: 1.12e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6296 (18%) - MXAN_7143 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 35% E-Value: 5.04e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (18%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 33% E-Value: 3.38e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (17%) - MXAN_7143 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 35% E-Value: 1.42e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7143 (19%) - MXAN_4645 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 32% E-Value: 3.49e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_5995 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 33% E-Value: 3.86e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (19%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 32% E-Value: 5.39e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_6296 (18%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 33% E-Value: 4.41e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

sll1228 (16%) - sll1229 (23%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 20% Positives: 32% E-Value: 7.78e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

aglZ (16%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 6.58e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

frzS (17%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 33% E-Value: 5.76e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_4645 (17%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 33% E-Value: 1.24e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

aglZ (16%) - MXAN_1349 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 32% E-Value: 2.26e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 32% E-Value: 3.86e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5853 (17%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 33% E-Value: 1.33e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_6149 (16%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 31% E-Value: 1.68e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_2606 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 4.88e-06

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (14%) - MXAN_4645 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 7.28e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Domain-Domain Interactions (2)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Response_reg
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Trans_reg_C

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