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The Microbial Protein Interaction Database

Interaction Evidences

MXAN_7398 - MXAN_5889 ( Myxococcus xanthus (strain DK 1622) )

Protein A	Protein B
Q1CVR8 Sensor protein MXAN_7398	Q1CZZ7 Response regulator MXAN_5889
CMR Search...	CMR Search...
GO MF: two-component sensor activity GO MF: ATP binding GO CC: membrane GO BP: signal transduction GO BP: peptidyl-histidine phosphorylation	GO MF: two-component response regulator activity GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...

List of evidences (83)

Experiments (1)

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Interologs (81)

MXAN_7398 (79%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 47% Positives: 59% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (79%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 45% Positives: 56% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (79%) - cheB1 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 42% Positives: 52% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_5889 (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 32% E-Value: 2.87e-48

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (6%) - MXAN_5889 (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 33% E-Value: 9.23e-51

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (8%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 8.43e-16

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

asgD (7%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 22% E-Value: 1.94e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 21% E-Value: 4.63e-10

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

sdeK (8%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 22% E-Value: 7.64e-13

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1166 (7%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 21% E-Value: 2.37e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 1.18e-17

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7363 (8%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 3.66e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 21% E-Value: 1.03e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (8%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 1.88e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 2.62e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr2098 (8%) - slr2100 (25%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 7.63e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

kdpD (7%) - A2VGV6 (27%) (Mycobacterium tuberculosis C - Mycobacterium tuberculosis)

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 5.47e-11

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Davey CA et al. (2002)

MXAN_2606 (29%) - MXAN_2606 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 1.10e-15

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5211 (7%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 1.65e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5314 (7%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 4.19e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1350 (7%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 7.63e-17

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR3 (6%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 1.49e-12

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_1680 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 3.80e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7059 (8%) - MXAN_1680 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 6.91e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (7%) - MXAN_1680 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 6.25e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 6.25e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 9.03e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (7%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 3.79e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (7%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 2.15e-15

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1350 (7%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 1.49e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 2.29e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (7%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 3.67e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (7%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 2.45e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (8%) - MXAN_5313 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 1.39e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - MXAN_5313 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 2.37e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (8%) - MXAN_5313 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 2.90e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7142 (7%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 6.69e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr1147 (6%) - slr1783 (26%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 1.10e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

sll1228 (7%) - sll1229 (22%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 6.26e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr0533 (7%) - sll0649 (24%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 5.47e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

prrB (5%) - prrA (30%) (Mycobacterium tuberculosis)

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 8.74e-09

Method	DB Source	Type	Publication
enzymatic study		direct interaction	Nowak E et al. (2006)

arcB (7%) - cheY (24%) (Escherichia coli O157:H7 - Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 2.15e-11

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Kato M et al. (1999)

pleC (7%) - pleD (24%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 5.65e-16

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

divJ (7%) - pleD (24%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 2.45e-15

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

asgD (7%) - cheB1 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 3.10e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (7%) - cheB1 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 1.76e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - cheB1 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 7.40e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (7%) - frzS (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 3.21e-15

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

pilS (6%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 7.15e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1350 (7%) - cheB1 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 1.22e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (7%) - frzS (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 2.22e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR2 (6%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 3.21e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

pilS (6%) - MXAN_1680 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 5.85e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (7%) - MXAN_1680 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 1.35e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (6%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 3.21e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5314 (7%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 8.17e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (7%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 3.21e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3606 (6%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 9.99e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_4165 (6%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 5.12e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR3 (6%) - MXAN_5313 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 5.66e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (6%) - MXAN_5313 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 2.72e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (6%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 1.03e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (6%) - MXAN_1680 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 8.45e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (6%) - MXAN_4164 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 2.30e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - phoP1 (24%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 6.04e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

BruAb1_0598 (7%) - divK (20%) (Brucella abortus)

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 1.30e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Hallez R et al. (2007)

sll1353 (7%) - sll1905 (23%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 1.59e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

slr0210 (7%) - slr1909 (21%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 9.02e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1393 (6%) - slr1037 (24%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 1.82e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

pleC (7%) - divK (20%) (Brucella abortus - Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 9.02e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Hallez R et al. (2007)

pleC (7%) - divK (22%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 2.63e-13

Method

DB Source

Type

Publication

dephosphorylation

phosphorylation

divJ (7%) - divK (22%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 1.14e-12

Method

DB Source

Type

Publication

protein kinase assay

phosphorylation

Paul R et al. (2008)

phoR1 (7%) - MXAN_1349 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 21% E-Value: 1.94e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (7%) - MXAN_1349 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 20% E-Value: 3.43e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pdhS (7%) - divK (20%) (Brucella abortus)

Geometric mean of BLAST Identity: 11% Positives: 21% E-Value: 2.81e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Hallez R et al. (2007)

sasA (6%) - sll1291 (20%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 11% Positives: 20% E-Value: 1.39e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

envZ (6%) - ompR (21%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 20% E-Value: 3.80e-08

Method	DB Source	Type	Publication
electrophoretic mobility shift assay		physical association	Harlocker SL et al. (1995)
far western blotting		physical association	Cai SJ et al. (2002)
pull down		physical association	Cai SJ et al. (2002)

glnL (7%) - glnG (18%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 2.22e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Salinas P et al. (2003)

sll1003 (5%) - slr1909 (21%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 18% E-Value: 2.63e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr2104 (7%) - slr1305 (14%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 18% E-Value: 2.15e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1905 (7%) - slr1305 (14%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 1.82e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

Domain-Domain Interactions (1)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID	predicted interaction	Response_reg	HisKA

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