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The Microbial Protein Interaction Database

Interaction Evidences

asgD - pilR ( Myxococcus xanthus (strain DK 1622) )

Protein A	Protein B
Q1CWW4 Sensor protein asgD MXAN_6996	Q1D0A2 Pilin regulatory protein PilR pilR MXAN_5784
CMR Search...	CMR Search...
GO MF: two-component sensor activity GO MF: ATP binding GO MF: two-component response regulator activity GO CC: membrane GO BP: regulation of transcription, DNA-dependent GO BP: peptidyl-histidine phosphorylation GO BP: two-component signal transduction system (p...	GO MF: transcription factor binding GO MF: transcription factor activity GO MF: nucleoside-triphosphatase activity GO MF: ATP binding GO MF: two-component response regulator activity GO CC: intracellular GO BP: transcription GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p...

List of evidences (146)

Experiments (1)

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Interologs (142)

asgD (87%) - MXAN_7143 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 60% Positives: 70% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (87%) - nla28 (37%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 57% Positives: 70% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (87%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 37% Positives: 48% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (87%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 28% Positives: 35% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (87%) - phoP3 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 34% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (7%) - pilR (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 33% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (18%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 39% E-Value: 2.14e-63

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (87%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 32% E-Value: 0

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

asgD (87%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 31% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (5%) - pilR (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 27% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (5%) - pilR (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 30% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (5%) - pilR (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 29% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (5%) - pilR (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 27% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (5%) - pilR (100%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 28% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (10%) - MXAN_7143 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 29% E-Value: 1.75e-57

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (10%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 29% E-Value: 5.44e-59

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - MXAN_7143 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 25% E-Value: 4.78e-47

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (8%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 25% E-Value: 6.45e-48

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (5%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 20% E-Value: 2.15e-47

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

glnG (37%) - glnG (6%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 2.71e-42

Method	DB Source	Type	Publication
two hybrid		physical association	Salinas P et al. (2003)

MXAN_7398 (18%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 5.14e-25

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (4%) - MXAN_7143 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 6.90e-46

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (5%) - MXAN_7143 (42%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 20% E-Value: 1.64e-47

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (5%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 6.67e-49

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7059 (11%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 19% E-Value: 4.98e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (11%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 2.47e-19

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

sdeK (10%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 20% E-Value: 1.55e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (4%) - MXAN_5853 (39%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 2.15e-47

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (18%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 18% E-Value: 1.60e-22

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

sdeK (10%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 19% E-Value: 3.12e-18

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR1 (7%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 4.23e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (18%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.40e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 17% E-Value: 1.66e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 8.25e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7398 (18%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 11% Positives: 18% E-Value: 1.40e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1672 (5%) - slr1529 (18%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 17% E-Value: 9.41e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_7143 (6%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 16% E-Value: 1.45e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (11%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 14% E-Value: 2.24e-20

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7059 (11%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 14% E-Value: 1.55e-21

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7059 (11%) - MXAN_1680 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 15% E-Value: 8.50e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (10%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 14% E-Value: 1.40e-18

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

sdeK (10%) - MXAN_5313 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 10% Positives: 14% E-Value: 5.69e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (5%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 3.83e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (5%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 1.90e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cheB1 (5%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 8.25e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cheB1 (5%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 4.09e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP3 (5%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 9.74e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (5%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 6.11e-06

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1350 (7%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 6.75e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0460 (11%) - MXAN_0460 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 1.90e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

pilR (5%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 6.11e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 3.58e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (10%) - MXAN_5995 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 1.60e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (10%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 4.08e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (5%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 1.45e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7059 (11%) - MXAN_5212 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 2.02e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (8%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 2.32e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (6%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 15% E-Value: 5.00e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (11%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 5.69e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (8%) - MXAN_5313 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 13% E-Value: 9.42e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (8%) - MXAN_0460 (11%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 9% Positives: 14% E-Value: 1.55e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

slr1305 (6%) - sll1905 (11%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.27e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

yycG (7%) - yycF (8%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 6.75e-09

Method	DB Source	Type	Publication
enzymatic study		physical association	Fukuchi K et al. (2000)

kdpD (8%) - kdpE (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 9.42e-11

Method	DB Source	Type	Publication
adenylate cyclase complementation		physical association	Luttmann D et al. (2009)
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)
enzymatic study		physical association	Heermann R et al. (2003)
protein kinase assay		physical association	Luttmann D et al. (2009)

MXAN_1350 (7%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 7.22e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoP2 (4%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 1.23e-06

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoP2 (4%) - MXAN_7396 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 14% E-Value: 6.11e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (7%) - MXAN_1680 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 2.74e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 3.83e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - phoP3 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 4.37e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 2.65e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.11e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_4645 (5%) - asgD (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 2.93e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - MXAN_1349 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.19e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_5995 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 8.53e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 7.46e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 13% E-Value: 5.17e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - MXAN_5313 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.55e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (8%) - MXAN_5995 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 8% Positives: 12% E-Value: 1.90e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1475 (7%) - slr1584 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 8.53e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

sll1353 (4%) - sll1905 (11%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 9.74e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

CcaS (7%) - slr1584 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 8.53e-08

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation reaction	Hirose Y et al. (2008)

cpxR (8%) - cpxR (5%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 2.10e-10

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

arcB (6%) - cheY (8%) (Escherichia coli O157:H7 - Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 3.24e-07

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Kato M et al. (1999)

MXAN_2606 (5%) - MXAN_5995 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.96e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (5%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 10% E-Value: 2.84e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (9%) - MXAN_2606 (5%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.72e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

cheB1 (5%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 3.70e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (5%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 10% E-Value: 5.53e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_3450 (9%) - MXAN_3450 (5%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 10% E-Value: 3.83e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (5%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.19e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7143 (6%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.90e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (5%) - MXAN_5995 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 6.32e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (5%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 5.53e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (5%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 3.83e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (5%) - MXAN_3450 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 10% E-Value: 1.04e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (5%) - MXAN_1680 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 2.10e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (5%) - MXAN_1680 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 2.10e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (5%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 10% E-Value: 1.32e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1350 (7%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 1.84e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1349 (5%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 3.83e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 1.90e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (6%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 4.52e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (6%) - MXAN_1680 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 1.72e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (8%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 1.90e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilR (5%) - MXAN_5313 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 11% E-Value: 2.24e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4645 (5%) - MXAN_5313 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 10% E-Value: 5.34e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (7%) - phoP1 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 7% Positives: 12% E-Value: 3.35e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

HP_0392 (5%) - cheY (7%) (Helicobacter pylori (Campylobacter pylori))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 9.74e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Rain JC et al. (2001)

sll0797 (9%) - sll0797 (4%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 3.70e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1228 (5%) - sll1229 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 3.70e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr2104 (5%) - slr1305 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 8.81e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1905 (6%) - slr1305 (7%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 3.70e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr0533 (5%) - sll0649 (8%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 1.90e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

phoP (8%) - phoP (5%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 2.32e-09

Method	DB Source	Type	Publication
genetic interference		physical association	Chen Y et al. (2003)
x-ray crystallography		physical association	Chen Y et al. (2003)

yedW (8%) - yedW (5%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 1.27e-07

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

ompR (8%) - ompR (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 3.24e-11

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoB (5%) - ompR (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 8.24e-11

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

ompR (4%) - phoB (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 1.78e-09

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoB (8%) - phoB (5%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 4.52e-09

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

arcA (9%) - arcA (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 3.46e-09

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

qseB (9%) - qseB (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 2.93e-08

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

baeR (7%) - baeR (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 2.40e-06

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

cusR (4%) - yedW (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 2.10e-06

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

cusR (8%) - cusR (4%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 9% E-Value: 1.90e-07

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

yedW (5%) - cusR (8%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 1.15e-08

Method	DB Source	Type	Publication
fluorescent resonance energy transfer		physical association	Gao R et al. (2008)

phoP2 (4%) - MXAN_2606 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 5.53e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoP2 (8%) - phoP2 (4%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 9% E-Value: 1.61e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (5%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 5.00e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_4645 (5%) - MXAN_5995 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 1.50e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7143 (6%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 1.66e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5995 (5%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 9% E-Value: 7.22e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (5%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 4.37e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (5%) - MXAN_1349 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 11% E-Value: 5.34e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3450 (5%) - MXAN_5212 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 9% E-Value: 5.00e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4164 (7%) - MXAN_4164 (6%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 1.15e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (5%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 4.37e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1680 (5%) - MXAN_4164 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 3.83e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (5%) - phoP2 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 9% E-Value: 3.46e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5313 (5%) - MXAN_4645 (7%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 9% E-Value: 3.03e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoP2 (4%) - MXAN_5313 (9%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 2.24e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7024 (5%) - MXAN_5212 (8%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 6% Positives: 10% E-Value: 2.65e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

Domain-Domain Interactions (3)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Response_reg
structural domain contact	3DID,iPfam	predicted interaction	Response_reg	Sigma54_activat
structural domain contact	3DID	predicted interaction	Response_reg	HisKA

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