The Microbial Protein Interaction Database

physical association

phoR1 (87%) - MXAN_3450 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 48% Positives: 60% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (87%) - MXAN_2606 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 33% Positives: 45% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (26%) - MXAN_5313 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 30% Positives: 42% E-Value: 6.96e-30

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

yycG (27%) - yycF (30%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 29% Positives: 43% E-Value: 3.95e-29

Method	DB Source	Type	Publication
enzymatic study		physical association	Fukuchi K et al. (2000)

MXAN_2785 (25%) - MXAN_5995 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 40% E-Value: 3.58e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (21%) - MXAN_5313 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 27% Positives: 39% E-Value: 2.40e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (25%) - MXAN_3450 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 39% E-Value: 4.67e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (25%) - MXAN_4164 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 26% Positives: 41% E-Value: 5.70e-24

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (21%) - phoP2 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 25% Positives: 36% E-Value: 1.15e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pilS (21%) - MXAN_3450 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 24% Positives: 36% E-Value: 1.36e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4165 (20%) - MXAN_4164 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 23% Positives: 38% E-Value: 8.53e-16

Method

DB Source

Type

Publication

physical association

slr0533 (17%) - sll0649 (30%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 22% Positives: 33% E-Value: 4.09e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

pilS (21%) - MXAN_1680 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 35% E-Value: 1.84e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (15%) - MXAN_1349 (32%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 30% E-Value: 7.46e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

creC (14%) - creB (32%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 21% Positives: 30% E-Value: 6.31e-19

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

MXAN_5314 (17%) - MXAN_3450 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 33% E-Value: 2.17e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (15%) - phoP2 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 29% E-Value: 9.75e-16

Method

DB Source

Type

Publication

physical association

CcaS (21%) - slr1584 (19%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 20% Positives: 33% E-Value: 1.11e-15

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation reaction	Hirose Y et al. (2008)

MXAN_2606 (15%) - MXAN_5995 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 30% E-Value: 8.82e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (15%) - MXAN_3450 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 29% E-Value: 1.15e-16

Method

DB Source

Type

Publication

physical association

asgD (14%) - phoP2 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 29% E-Value: 1.01e-12

Method

DB Source

Type

Publication

physical association

MXAN_1350 (17%) - MXAN_1680 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 2.10e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (15%) - MXAN_4164 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 20% Positives: 31% E-Value: 1.41e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

BruAb1_0598 (25%) - divK (14%) (Brucella abortus)

Geometric mean of BLAST Identity: 19% Positives: 28% E-Value: 1.01e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Hallez R et al. (2007)

sll0790 (15%) - sll0789 (25%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 19% Positives: 31% E-Value: 3.96e-17

Method

DB Source

Type

Publication

physical association

divJ (23%) - pleD (15%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 19% Positives: 28% E-Value: 1.27e-15

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

kdpD (13%) - kdpE (27%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 2.48e-15

Method	DB Source	Type	Publication
adenylate cyclase complementation		physical association	Luttmann D et al. (2009)
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)
enzymatic study		physical association	Heermann R et al. (2003)
protein kinase assay		physical association	Luttmann D et al. (2009)

divJ (23%) - divK (14%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 18% Positives: 27% E-Value: 4.10e-14

Method

DB Source

Type

Publication

protein kinase assay

phosphorylation

Paul R et al. (2008)

MXAN_7398 (11%) - phoP2 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 25% E-Value: 1.08e-14

Method

DB Source

Type

Publication

physical association

MXAN_2785 (25%) - MXAN_2606 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 2.03e-17

Method

DB Source

Type

Publication

physical association

MXAN_2785 (25%) - MXAN_4645 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 28% E-Value: 9.42e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (26%) - MXAN_2606 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 1.72e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (11%) - MXAN_4164 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 27% E-Value: 1.56e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pdhS (21%) - divK (14%) (Brucella abortus)

Geometric mean of BLAST Identity: 17% Positives: 27% E-Value: 1.19e-13

Method

DB Source

Type

Publication

physical association

Hallez R et al. (2007)

sll1475 (15%) - slr1584 (19%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 17% Positives: 27% E-Value: 2.17e-15

Method

DB Source

Type

Publication

physical association

envZ (12%) - ompR (25%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 17% Positives: 31% E-Value: 6.33e-11

Method	DB Source	Type	Publication
electrophoretic mobility shift assay		physical association	Harlocker SL et al. (1995)
far western blotting		physical association	Cai SJ et al. (2002)
pull down		physical association	Cai SJ et al. (2002)

MXAN_7206 (10%) - MXAN_3450 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 24% E-Value: 2.03e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (10%) - phoP2 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 24% E-Value: 1.72e-12

Method

DB Source

Type

Publication

physical association

MXAN_5211 (10%) - phoP2 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 24% E-Value: 5.18e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (10%) - MXAN_4164 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 25% E-Value: 2.48e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (8%) - MXAN_5313 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 24% E-Value: 1.50e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (9%) - MXAN_5313 (34%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 25% E-Value: 9.75e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (10%) - MXAN_5212 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 24% E-Value: 1.36e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (10%) - MXAN_4164 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 26% E-Value: 5.53e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (11%) - MXAN_5995 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 25% E-Value: 6.12e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cpxA (9%) - cpxR (27%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 16% Positives: 25% E-Value: 1.11e-15

Method	DB Source	Type	Publication
unspecified method		physical association	Nakayama S et al. (2003)

sll0798 (11%) - sll0797 (23%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 16% Positives: 25% E-Value: 1.23e-14

Method

DB Source

Type

Publication

physical association

slr1147 (12%) - sll0797 (23%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 16% Positives: 25% E-Value: 5.01e-12

Method

DB Source

Type

Publication

physical association

prrB (8%) - prrA (30%) (Mycobacterium tuberculosis)

Geometric mean of BLAST Identity: 16% Positives: 23% E-Value: 1.78e-13

Method	DB Source	Type	Publication
enzymatic study		direct interaction	Nowak E et al. (2006)

arcB (20%) - cheY (12%) (Escherichia coli O157:H7 - Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 9.76e-12

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Kato M et al. (1999)

pleC (17%) - pleD (15%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 16% Positives: 23% E-Value: 1.15e-16

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

pilS (21%) - MXAN_2606 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 5.92e-13

Method

DB Source

Type

Publication

physical association

MXAN_5211 (10%) - MXAN_3450 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 24% E-Value: 6.12e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (10%) - MXAN_1680 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 23% E-Value: 2.75e-10

Method

DB Source

Type

Publication

physical association

sdeK (9%) - MXAN_5995 (28%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 24% E-Value: 4.24e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (9%) - phoP2 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 24% E-Value: 4.69e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (9%) - MXAN_3450 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 24% E-Value: 5.35e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (9%) - phoP2 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 24% E-Value: 4.53e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (10%) - MXAN_4164 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 25% E-Value: 7.47e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5996 (10%) - MXAN_1680 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 23% E-Value: 6.12e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

pleC (17%) - divK (14%) (Brucella abortus - Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 2.17e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Hallez R et al. (2007)

pleC (17%) - divK (14%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 3.71e-15

Method

DB Source

Type

Publication

dephosphorylation

phosphorylation

MXAN_7059 (9%) - MXAN_3450 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 4.38e-12

Method

DB Source

Type

Publication

physical association

MXAN_1350 (17%) - MXAN_2606 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 6.75e-17

Method

DB Source

Type

Publication

physical association

phoR3 (8%) - phoP2 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 7.23e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR2 (8%) - phoP2 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 5.36e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (10%) - MXAN_1680 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 8.27e-11

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5314 (17%) - MXAN_4645 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 4.38e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (17%) - MXAN_4645 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 3.13e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (9%) - MXAN_5212 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 23% E-Value: 1.32e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (9%) - MXAN_4164 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 5.35e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

kdpD (8%) - A2VGV6 (25%) (Mycobacterium tuberculosis C - Mycobacterium tuberculosis)

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 2.25e-12

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Davey CA et al. (2002)

MXAN_2606 (12%) - MXAN_2606 (15%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 5.01e-12

Method

DB Source

Type

Publication

physical association

MXAN_5314 (17%) - MXAN_2606 (12%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 9.45e-11

Method

DB Source

Type

Publication

physical association

phoR2 (8%) - MXAN_3450 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 6.33e-11

Method

DB Source

Type

Publication

physical association

MXAN_7059 (9%) - MXAN_1680 (23%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 5.92e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (14%) - MXAN_4645 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 2.41e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (15%) - MXAN_4645 (13%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 21% E-Value: 2.32e-13

Method

DB Source

Type

Publication

physical association

MXAN_3606 (7%) - MXAN_5212 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 22% E-Value: 9.76e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoQ (7%) - phoP (22%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 2.49e-07

Method	DB Source	Type	Publication
far western blotting		physical association	Chamnongpol S et al. (2000)
surface plasmon resonance		physical association	Castelli ME et al. (2003)

sll1353 (14%) - sll1905 (13%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 21% E-Value: 1.46e-11

Method

DB Source

Type

Publication

physical association