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The Microbial Protein Interaction Database

Interaction Evidences

pleC - divK ( Caulobacter crescentus (Caulobacter vibrioides) )

Protein A	Protein B
P37894 Non-motile and phage-resistance protein pleC CC_2482	Q45976 Cell division response regulator DivK divK
CMR Search...	CMR Search...
GO MF: two-component sensor activity GO MF: protein binding GO MF: ATP binding GO CC: integral to membrane GO CC: plasma membrane GO BP: regulation of transcription, DNA-dependent GO BP: cell differentiation GO BP: peptidyl-histidine phosphorylation GO BP: two-component signal transduction system (p... GO BP: cell cycle	GO MF: protein binding GO MF: two-component response regulator activity GO BP: regulation of transcription, DNA-dependent GO BP: two-component signal transduction system (p... GO BP: cell division

List of evidences (156)

Experiments (2)

Method

DB Source

Type

Publication

dephosphorylation

phosphorylation

pleC (83%) - divK (76%) (Brucella abortus - Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 79% Positives: 85% E-Value: 0

Method	DB Source	Type	Publication
two hybrid		physical association	Hallez R et al. (2007)

pleC (83%) - pleD (34%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 53% Positives: 68% E-Value: 0

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

divJ (14%) - divK (100%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 37% Positives: 43% E-Value: 2.59e-58

Method

DB Source

Type

Publication

protein kinase assay

phosphorylation

Paul R et al. (2008)

pdhS (16%) - divK (76%) (Brucella abortus)

Geometric mean of BLAST Identity: 35% Positives: 46% E-Value: 7.81e-51

Method

DB Source

Type

Publication

two hybrid

physical association

Hallez R et al. (2007)

BruAb1_0598 (11%) - divK (76%) (Brucella abortus)

Geometric mean of BLAST Identity: 29% Positives: 38% E-Value: 5.07e-46

Method	DB Source	Type	Publication
two hybrid		physical association	Hallez R et al. (2007)

MXAN_2785 (17%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 22% Positives: 35% E-Value: 4.18e-20

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

divJ (14%) - pleD (34%) (Caulobacter crescentus (Caulobacter vibrioides))

Geometric mean of BLAST Identity: 21% Positives: 33% E-Value: 6.64e-34

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Paul R et al. (2008)

MXAN_2785 (17%) - MXAN_5995 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 36% E-Value: 2.01e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 37% E-Value: 2.14e-20

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 37% E-Value: 3.20e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 36% E-Value: 6.90e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (27%) - MXAN_2785 (17%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 35% E-Value: 7.13e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_7363 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 35% E-Value: 5.46e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2785 (17%) - MXAN_4164 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 21% Positives: 37% E-Value: 1.22e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1905 (13%) - slr1305 (27%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 19% Positives: 31% E-Value: 5.27e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1353 (11%) - sll1905 (34%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 19% Positives: 29% E-Value: 4.77e-24

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

phoR1 (10%) - phoP1 (36%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 19% Positives: 29% E-Value: 4.04e-23

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll0474 (12%) - slr1400 (27%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 9.93e-26

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

sll1228 (11%) - sll1229 (30%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 1.14e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1888 (10%) - divK (34%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 2.62e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr2104 (12%) - slr1305 (27%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 3.90e-26

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1393 (9%) - slr1037 (34%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 1.44e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1759 (13%) - slr1760 (24%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 2.71e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr2098 (10%) - slr2100 (31%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 18% Positives: 26% E-Value: 5.64e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

torS (11%) - torR (28%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 18% Positives: 28% E-Value: 4.94e-17

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

sdeK (11%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 1.30e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR1 (10%) - MXAN_1349 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 29% E-Value: 6.66e-22

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (10%) - MXAN_1349 (33%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 30% E-Value: 1.44e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (11%) - MXAN_5313 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 18% Positives: 31% E-Value: 9.98e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

bvgS (14%) - bvgA (21%) (Bordetella pertussis)

Geometric mean of BLAST Identity: 17% Positives: 27% E-Value: 1.30e-21

Method	DB Source	Type	Publication
genetic interference		physical association	Merkel TJ et al. (2003)

slr1759 (13%) - slr1594 (22%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 6.90e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

MXAN_2606 (10%) - MXAN_5995 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 2.80e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (29%) - MXAN_2606 (10%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 5.84e-18

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

asgD (9%) - phoP3 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 2.15e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (10%) - frzS (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 3.42e-18

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1350 (10%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 5.11e-14

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (10%) - phoP2 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 2.45e-16

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR1 (10%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 26% E-Value: 2.71e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (10%) - phoP3 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 7.62e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (11%) - MXAN_5995 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 6.26e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (11%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 6.69e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sdeK (11%) - phoP2 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 30% E-Value: 5.48e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (10%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 9.63e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (10%) - MXAN_2785 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 27% E-Value: 9.96e-18

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (10%) - MXAN_4164 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 1.70e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (9%) - MXAN_5313 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 29% E-Value: 2.53e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (10%) - MXAN_5313 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 17% Positives: 28% E-Value: 2.07e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

slr0210 (10%) - sll1624 (25%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 1.64e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr0533 (8%) - sll0649 (32%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 16% Positives: 30% E-Value: 8.43e-17

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

yycG (8%) - yycF (33%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 9.96e-18

Method	DB Source	Type	Publication
enzymatic study		physical association	Fukuchi K et al. (2000)

MXAN_7059 (9%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 9.66e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

asgD (9%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 7.64e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (10%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 2.99e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (10%) - frzS (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 31% E-Value: 3.00e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1350 (10%) - MXAN_0460 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 30% E-Value: 1.54e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (10%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 1.39e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (10%) - MXAN_0460 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 8.15e-20

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (10%) - phoP2 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 1.14e-17

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_2606 (10%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 29% E-Value: 4.47e-18

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1350 (10%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 30% E-Value: 3.92e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (9%) - MXAN_2785 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 1.65e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR1 (10%) - MXAN_2785 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 4.62e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (9%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 3.31e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7363 (9%) - MXAN_2785 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 5.64e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR1 (10%) - MXAN_7363 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 26% E-Value: 3.54e-19

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (10%) - MXAN_7363 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 27% E-Value: 7.62e-18

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7059 (9%) - MXAN_4164 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 16% Positives: 28% E-Value: 2.81e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

cph1 (8%) - rcp1 (27%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 15% Positives: 28% E-Value: 5.84e-14

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation	Yeh KC et al. (1997)
protein kinase assay		phosphorylation	Lamparter T et al. (2001)

slr0210 (10%) - slr1909 (24%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 2.53e-21

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sasA (8%) - sll1291 (27%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 3.54e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

arcB (9%) - hnr (23%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 2.80e-16

Method	DB Source	Type	Publication
enzymatic study		physical association	Mika F et al. (2005)

arcB (9%) - cheY (25%) (Escherichia coli O157:H7 - Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 2.90e-17

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Kato M et al. (1999)

MXAN_7059 (9%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 29% E-Value: 4.95e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

asgD (9%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 28% E-Value: 3.92e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 1.95e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 9.98e-10

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7398 (8%) - MXAN_0460 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 7.89e-15

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_0460 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 5.85e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR2 (7%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 24% E-Value: 6.47e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7398 (8%) - phoP2 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 1.10e-12

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7206 (8%) - phoP2 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 8.17e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

asgD (9%) - phoP2 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 3.21e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7398 (8%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 2.01e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 1.49e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (9%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 5.85e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (8%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 4.33e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 3.21e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (8%) - MXAN_5889 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 2.90e-13

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_5889 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 2.15e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_2785 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 25% E-Value: 3.32e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

asgD (9%) - MXAN_2785 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 26% E-Value: 1.30e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (8%) - MXAN_4164 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 7.63e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_4164 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 5.66e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (8%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 15% Positives: 27% E-Value: 6.26e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_2606 (10%) - frzZ (20%) (Myxococcus xanthus (strain DK 1622) - Myxococcus xanthus)

Geometric mean of BLAST Identity: 14% Positives: 28% E-Value: 7.62e-18

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

cpxA (7%) - cpxR (27%) (Salmonella typhimurium)

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 1.35e-10

Method	DB Source	Type	Publication
unspecified method		physical association	Nakayama S et al. (2003)

sll1003 (9%) - slr1909 (24%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 7.14e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

slr1805 (7%) - sll1708 (28%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 3.00e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

kinA (7%) - spo0F (30%) (Bacillus subtilis)

Geometric mean of BLAST Identity: 14% Positives: 28% E-Value: 3.43e-14

Method	DB Source	Type	Publication
genetic interference		physical association	Stephenson SJ et al. (2002)

kdpD (8%) - A2VGV6 (26%) (Mycobacterium tuberculosis C - Mycobacterium tuberculosis)

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 2.63e-10

Method	DB Source	Type	Publication
x-ray crystallography		physical association	Davey CA et al. (2002)

creC (7%) - creB (28%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 1.18e-10

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

zraS (7%) - zraR (25%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 3.66e-12

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

kdpD (7%) - kdpE (27%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 1.65e-12

Method	DB Source	Type	Publication
adenylate cyclase complementation		physical association	Luttmann D et al. (2009)
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)
enzymatic study		physical association	Heermann R et al. (2003)
protein kinase assay		physical association	Luttmann D et al. (2009)

MXAN_2606 (10%) - cheB1 (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 27% E-Value: 2.45e-16

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5314 (7%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 24% E-Value: 1.39e-07

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_1350 (10%) - cheB1 (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 28% E-Value: 2.15e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR2 (7%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 3.32e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (6%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 5.66e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

phoR2 (7%) - phoP2 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 2.72e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_1166 (7%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 23% E-Value: 9.34e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (7%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 2.63e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (7%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 4.33e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR2 (7%) - MXAN_4072 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 1.07e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7398 (8%) - MXAN_7363 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 3.43e-14

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - MXAN_7363 (25%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 2.54e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (6%) - MXAN_5313 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 25% E-Value: 4.33e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (8%) - MXAN_5995 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 1.82e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (8%) - MXAN_0460 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 14% Positives: 26% E-Value: 1.14e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

sll1229 (7%) - sll1228 (26%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 24% E-Value: 4.48e-10

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sasA (8%) - slr1594 (22%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 24% E-Value: 4.19e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

sll1475 (8%) - slr1584 (22%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 25% E-Value: 1.39e-11

Method

DB Source

Type

Publication

two hybrid

physical association

Sato S et al. (2007)

CcaS (8%) - slr1584 (22%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 13% Positives: 25% E-Value: 1.39e-11

Method	DB Source	Type	Publication
protein kinase assay		phosphorylation reaction	Hirose Y et al. (2008)

MXAN_5211 (6%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 23% E-Value: 2.46e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_5211 (6%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 24% E-Value: 1.26e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

asgD (9%) - cheB1 (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 26% E-Value: 3.21e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5314 (7%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 26% E-Value: 7.15e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_7206 (8%) - cheB1 (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 25% E-Value: 8.17e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

pilS (5%) - MXAN_2606 (29%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 23% E-Value: 9.34e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

MXAN_7398 (8%) - cheB1 (20%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 25% E-Value: 1.10e-12

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (6%) - MXAN_0460 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 23% E-Value: 7.39e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (6%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 25% E-Value: 2.90e-09

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (6%) - phoP2 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 24% E-Value: 2.38e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (6%) - phoP2 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 24% E-Value: 1.03e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_3451 (7%) - phoP2 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 25% E-Value: 1.10e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5314 (7%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 25% E-Value: 1.07e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (6%) - MXAN_4645 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 24% E-Value: 1.88e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

phoR3 (6%) - MXAN_5889 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 24% E-Value: 6.26e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (6%) - MXAN_2785 (27%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 22% E-Value: 4.19e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_5211 (6%) - MXAN_4164 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 24% E-Value: 7.15e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_4165 (7%) - MXAN_4164 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 24% E-Value: 7.39e-09

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

pilS (5%) - MXAN_5313 (31%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 24% E-Value: 7.15e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

MXAN_0459 (8%) - MXAN_4245 (22%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 13% Positives: 25% E-Value: 9.34e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

sll1334 (6%) - slr1909 (24%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 12% Positives: 22% E-Value: 2.46e-08

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

pilS (5%) - MXAN_7396 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 24% E-Value: 4.79e-08

Method

DB Source

Type

Publication

two hybrid

physical association

Whitworth DE et al. (2008)

pilS (5%) - phoP2 (26%) (Myxococcus xanthus (strain DK 1622))

Geometric mean of BLAST Identity: 12% Positives: 24% E-Value: 3.92e-06

Method	DB Source	Type	Publication
two hybrid		physical association	Whitworth DE et al. (2008)

yedV (5%) - yedW (26%) (Escherichia coli (strain K12))

Geometric mean of BLAST Identity: 11% Positives: 23% E-Value: 1.07e-07

Method	DB Source	Type	Publication
affinity chromatography technology		direct interaction	Yamamoto K et al. (2005)
biochemical		physical association	Yamamoto K et al. (2005)

sphS (5%) - slr1594 (22%) (Synechocystis sp (strain PCC 6803))

Geometric mean of BLAST Identity: 10% Positives: 20% E-Value: 6.92e-07

Method	DB Source	Type	Publication
two hybrid		physical association	Sato S et al. (2007)

Protein Complex Memberships (5)

Method	DB Source	Type	Publication
phosphatase assay		predicted interaction (assembly of 3 proteins)	Paul R et al. (2008)
protein kinase assay		predicted interaction (assembly of 3 proteins)	Paul R et al. (2008)
protein kinase assay		predicted interaction (assembly of 3 proteins)	Paul R et al. (2008)
cross-linking study		predicted interaction (assembly of 3 proteins)	Paul R et al. (2008)
enzymatic study		predicted interaction (assembly of 4 proteins)	Paul R et al. (2008)

Domain-Domain Interactions (2)

Method	DB Source	Type	Domain A	Domain B
structural domain contact	3DID	predicted interaction	Response_reg	HisKA
structural domain contact	3DID	predicted interaction	Response_reg	PAS

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