Anna Edlund, PhD

Assistant Professor

Anna Edlund is an assistant professor at the J. Craig Venter Institute in the Genomic Medicine group. Prior to her position at JCVI, Dr. Edlund was a post-doctoral fellow in natural products discovery, microbial chemical ecology and human microbiome research. Prior to joining JCVI, Dr. Edlund was an assistant professor at Stockholm University in the Department of Ecology, Environment, and Plant Sciences and on the faculty at San Diego State University in the Department of Biology.

She is passionate about understanding molecular mechanisms underlying the development of oral infectious disease, as well as mechanisms important in maintaining health. Her research focuses on developing in vitro tools that allow complex microbial communities to be reproducibly engineered, measured, and modeled. Such resources can facilitate the translation of microbiome discoveries into useful applications in medicine. Dr. Edlund’s research is funded by the NIH National Institute of Dental and Craniofacial Research (NIDCR).

She obtained her BASc in Biology and Microbiology from Sodertorn University, a BASc in Cell and Molecular Biology from the Karolinska Institute, and her PhD in Microbiology at the Swedish University of Agricultural Sciences in Uppsala.

Research Priorities

Oral microbial communities in health and disease
  • Identification of molecular mechanisms involved in the transition from a highly diverse and healthy oral microbiome to a disease-associated microbiome
  • Identification of molecular mechanisms involved in maintaining microbial community equilibrium (e.g. resistance to pathogen invasion)
  • Identification of causal gene and protein targets in disease and healthy states
The role of small molecules and their biosynthetic gene clusters in oral health and disease
  • Development of computational analysis approaches that facilitate our understanding of the wealth of natural products (NPs) human oral microbes can produce
  • Development of in vitro model systems to test ecological effects of NPs on health- and disease-associated microbial communities
  • The role of NPs in interactions between oral pathogens and commensal bacteria
Understanding the interplay between the complex oral microbiome and host factors (e.g. immune factors) in childhood caries (i.e. tooth decay)
  • Comparative microbiome-host analysis of healthy children and children with caries disease
  • Develop in vitro model systems of oral microbiomes representative of health and caries disease in children
  • Identification of causal target genes and proteins for childhood caries

Publications

Cariogenic Streptococcus mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization.
ACS infectious diseases. 2020-01-10;
PMID: 31906623
Discovery of a Novel Periodontal Disease-Associated Bacterium.
Microbial ecology. 2018-06-02;
PMID: 29860637
Targeted Antimicrobial Peptides: A Novel Technology to Eradicate Harmful Streptococcus Mutans.
Journal of the California Dental Association. 2017-10-01; 45.10: 557-564.
PMID: 29899655
Metabolic Fingerprints from the Human Oral Microbiome Reveal a Vast Knowledge Gap of Secreted Small Peptidic Molecules.
mSystems. 2017-07-01; 2.4:
PMID: 28761934
Uncovering the Horseshoe Effect in Microbial Analyses.
mSystems. 2017-01-01; 2.1:
PMID: 28251186
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.
Nature biotechnology. 2016-08-09; 34.8: 828-837.
PMID: 27504778
Metagenome and Metatranscriptome Analyses Using Protein Family Profiles.
PLoS computational biology. 2016-07-01; 12.7: e1004991.
PMID: 27400380
High-Quality Draft Genome Sequence of Low-pH-Active Veillonella parvula Strain SHI-1, Isolated from Human Saliva within an In Vitro Oral Biofilm Model.
Genome announcements. 2016-02-18; 4.1:
PMID: 26893419
Draft Genome Sequence of "Candidatus Bacteroides periocalifornicus," a New Member of the Bacteriodetes Phylum Found within the Oral Microbiome of Periodontitis Patients.
Genome announcements. 2015-12-23; 3.6:
PMID: 26701081
Meta-omics uncover temporal regulation of pathways across oral microbiome genera during in vitro sugar metabolism.
The ISME journal. 2015-12-01; 9.12: 2605-19.
PMID: 26023872
Bacteria-mediated effects of antibiotics on Daphnia nutrition.
Environmental science & technology. 2015-05-05; 49.9: 5779-87.
PMID: 25850437
Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle.
Proceedings of the National Academy of Sciences of the United States of America. 2015-01-06; 112.1: 244-9.
PMID: 25535390
Bacteriophage and their potential roles in the human oral cavity.
Journal of oral microbiology. 2015-01-01; 7.27423.
PMID: 25861745
An in vitro biofilm model system maintaining a highly reproducible species and metabolic diversity approaching that of the human oral microbiome.
Microbiome. 2013-10-02; 1.1: 25.
PMID: 24451062
Candidate phylum TM6 genome recovered from a hospital sink biofilm provides genomic insights into this uncultivated phylum.
Proceedings of the National Academy of Sciences of the United States of America. 2013-06-25; 110.26: E2390-9.
PMID: 23754396
Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform.
Genome research. 2013-05-01; 23.5: 867-77.
PMID: 23564253
Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes.
Journal of proteomics. 2012-08-30; 75.16: 5069-76.
PMID: 22641157
Microdiversity and evidence for high dispersal rates in the marine actinomycete 'Salinispora pacifica'.
Environmental microbiology. 2012-02-01; 14.2: 480-93.
PMID: 22117917
Antibiotic-induced change of bacterial communities associated with the copepod Nitocra spinipes.
PloS one. 2012-01-01; 7.5: e33107.
PMID: 22427962
Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicola.
Applied and environmental microbiology. 2011-09-01; 77.17: 5916-25.
PMID: 21724881
Use of bromodeoxyuridine immunocapture to identify psychrotolerant phenanthrene-degrading bacteria in phenanthrene-enriched polluted Baltic Sea sediments.
FEMS microbiology ecology. 2008-09-01; 65.3: 513-25.
PMID: 18616589
Active bacterial community structure along vertical redox gradients in Baltic Sea sediment.
Environmental microbiology. 2008-08-01; 10.8: 2051-63.
PMID: 18452546
Microbial community structure in polluted Baltic Sea sediments.
Environmental microbiology. 2006-02-01; 8.2: 223-32.
PMID: 16423011

Research Priorities

Oral microbial communities in health and disease
  • Identification of molecular mechanisms involved in the transition from a highly diverse and healthy oral microbiome to a disease-associated microbiome
  • Identification of molecular mechanisms involved in maintaining microbial community equilibrium (e.g. resistance to pathogen invasion)
  • Identification of causal gene and protein targets in disease and healthy states
The role of small molecules and their biosynthetic gene clusters in oral health and disease
  • Development of computational analysis approaches that facilitate our understanding of the wealth of natural products (NPs) human oral microbes can produce
  • Development of in vitro model systems to test ecological effects of NPs on health- and disease-associated microbial communities
  • The role of NPs in interactions between oral pathogens and commensal bacteria
Understanding the interplay between the complex oral microbiome and host factors (e.g. immune factors) in childhood caries (i.e. tooth decay)
  • Comparative microbiome-host analysis of healthy children and children with caries disease
  • Develop in vitro model systems of oral microbiomes representative of health and caries disease in children
  • Identification of causal target genes and proteins for childhood caries