Anna Edlund is an assistant professor at the J. Craig Venter Institute in the Genomic Medicine group. Prior to her position at JCVI, Dr. Edlund was a postdoctoral fellow in natural products discovery, microbial chemical ecology and human microbiome research. Prior to joining JCVI, Dr. Edlund was an assistant professor at Stockholm University in the Department of Ecology, Environment, and Plant Sciences and on the faculty at San Diego State University in the Department of Biology.
She is passionate about understanding molecular mechanisms underlying the development of oral infectious disease, as well as mechanisms important in maintaining health. Her research focuses on developing in vitro tools that allow complex microbial communities to be reproducibly engineered, measured, and modeled. Such resources can facilitate the translation of microbiome discoveries into useful applications in medicine. Dr. Edlund’s research is funded by the NIH National Institute of Dental and Craniofacial Research (NIDCR).
She obtained her BASc in Biology and Microbiology from Sodertorn University, a BASc in Cell and Molecular Biology from the Karolinska Institute, and her PhD in Microbiology at the Swedish University of Agricultural Sciences in Uppsala.
Oral microbial communities in health and disease
- Identification of molecular mechanisms involved in the transition from a highly diverse and healthy oral microbiome to a disease-associated microbiome
- Identification of molecular mechanisms involved in maintaining microbial community equilibrium (e.g. resistance to pathogen invasion)
- Identification of causal gene and protein targets in disease and healthy states
The role of small molecules and their biosynthetic gene clusters in oral health and disease
- Development of computational analysis approaches that facilitate our understanding of the wealth of natural products (NPs) human oral microbes can produce
- Development of in vitro model systems to test ecological effects of NPs on health- and disease-associated microbial communities
- The role of NPs in interactions between oral pathogens and commensal bacteria
Understanding the interplay between the complex oral microbiome and host factors (e.g. immune factors) in childhood caries (i.e. tooth decay)
- Comparative microbiome-host analysis of healthy children and children with caries disease
- Develop in vitro model systems of oral microbiomes representative of health and caries disease in children
- Identification of causal target genes and proteins for childhood caries