Bryan C. Frank, MSc, MBA, PMP

Staff Scientist



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Bryan Frank is a staff scientist for the Department of Infectious Disease at the J. Craig Venter Institute. He has been involved in a wide array of genomic and infectious disease-based studies dating back to his start at TIGR in 2001 working on mammalian models of human diseases. He developed high-throughput real-time quantitative RT-PCR and microarray protocols for the Institute running the TIGR Microarray Core Facility for its duration.

He has worked on a number or projects at JCVI related to persister states of Burkholderia, urine catheter biofilm and stool sample carbepenem resistance, multivalent vaccines for influenza, deep-sea soil core samplings, uranium mill tailings, as well as hypertension, pulmonary inflammation, autism, and other mammalian systemic conditions.

Bryan received his PMP (2017) from the Project Management Institute and his M.Sc. and MBA (2006) from Johns Hopkins University. He has worked in the Department of Infectious Disease since 2016.

Research Priorities

Studying host-pathogen interactions to elucidate gene networks critical to the infection pathway and for the host response

  • The role of B. pseudomallei persisters in meliodosis drug resistance and reemergence
  • S. aureus strain differences from a genomic and transcriptomic perspective in acquired resistant infections.

Antimicrobial resistance in the human microbiome and its correlation to disease manifestation.

  • Analysis of carbapenem resistance with indwelling urinary catheter biofilms
  • Exploring the existence of innate presence of antimicrobial resistance in fecal samples before and after malarial treatments

Development of robust and rapid detection methods for use in biosurveillance of environmentally complex communities.

  • Analysis of diverse aeronautical samples testing for incidental human microbiome transmission
  • Screening of variable aeronautical locations probing for the presence of fungal pathogens

Select Publications

Reducing the Bottleneck in Discovery of Novel Antibiotics.
Microbial ecology. 2017-04-01; 73.3: 658-667.
PMID: 27896376
The administration of intranasal live attenuated influenza vaccine induces changes in the nasal microbiota and nasal epithelium gene expression profiles.
Microbiome. 2015-12-15; 3.74.
PMID: 26667497
Genomic and transcriptomic differences in community acquired methicillin resistant Staphylococcus aureus USA300 and USA400 strains.
BMC genomics. 2014-12-19; 15.1145.
PMID: 25527145
A multi-omic systems approach to elucidating Yersinia virulence mechanisms.
Molecular bioSystems. 2013-01-27; 9.1: 44-54.
PMID: 23147219
A Multi-Omic View of Host-Pathogen-Commensal Interplay in Salmonella-Mediated Intestinal Infection.
PloS one. 2013-01-01; 8.12: e67155.
PMID: 23840608
Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation.
Molecular systems biology. 2012-06-26; 8.558.
PMID: 22735334
AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus.
Journal of the American Chemical Society. 2012-01-11; 134.1: 305-14.
PMID: 22122613
Comparative omics-driven genome annotation refinement: application across Yersiniae.
PloS one. 2012-01-01; 7.3: e33903.
PMID: 22479471
Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion.
Cancer research. 2010-09-01; 70.17: 6957-67.
PMID: 20651255