Chuck Merryman, PhD

Assistant Professor


858-750-4017

cmerryman

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Bio

Dr. Merryman's group is interested in tailoring the metabolism of synthetic cells. The lab employs a wide range of biochemical, molecular, and evolutionary approaches for the de novo construction of entire genomes and their subsequent evaluation. Methods for parallel genome assembly are being developed so that millions of rival genomic designs can be tested to identify those with the metabolic circuitry necessary for high-level compound production.

Previously, as a scientist with the Howard Hughes Medical Institute and as a postdoctoral researcher at M.I.T., Dr. Merryman developed methods for creating libraries of drug-like molecules and identifying desirable members through Mendelian evolution. Dr. Merryman holds bachelor's and master's degree's in chemistry and biophysics from the University of Montana, and a Ph.D. in molecular biology from the University of California at Santa Cruz.

Select Publications

Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome.
Science (New York, N.Y.). 2008-02-29; 319.5867: 1215-20.
PMID: 18218864
Transformation of aminoacyl tRNAs for the in vitro selection of "drug-like" molecules.
Chemistry & biology. 2004-04-01; 11.4: 575-82.
PMID: 15123252
A bifunctional tRNA for in vitro selection.
Chemistry & biology. 2002-06-01; 9.6: 741-6.
PMID: 12079786
Nucleotides in 16S rRNA protected by the association of 30S and 50S ribosomal subunits.
Journal of molecular biology. 1999-01-08; 285.1: 97-105.
PMID: 9878391
Nucleotides in 23S rRNA protected by the association of 30S and 50S ribosomal subunits.
Journal of molecular biology. 1999-01-08; 285.1: 107-13.
PMID: 9878392