Dominic Skinner, PhD

Postdoctoral Fellow

Dominic Skinner joined JCVI in 2021 as a postdoctoral fellow in Dr. Christine Cheng’s group. His current research projects use single nuclei transcriptomics to study opioid use disorder and HIV infection in clinical samples.

Previously, he worked under the mentorship of Dr. Thomas Lane at the University of Utah and University of California, Irvine studying the effects of the innate immune system on murine coronavirus infection of the central nervous system.

Dr. Skinner received his BSc in molecular and cellular biology from the University of Puget Sound and his PhD in neuroscience from the University of Utah.

Understanding brain circuitry changes in opioid use disorder and HIV infection
  • Profiling CNS and peripheral immune cells using snRNAseq, scRNAseq, ATACseq in separate brain regions in opioid and HIV infected clinical tissue
  • Using 3D-Organoid models to study effects of substance abuse on neurons, astrocytes, and oligodendrocytes in vitro

Publications

Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus.
Journal of virology. 2020-11-23; 94.24:
PMID: 32999036
Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system.
Glia. 2020-11-01; 68.11: 2345-2360.
PMID: 32449994
CXCR2 Signaling and Remyelination in Preclinical Models of Demyelination.
DNA and cell biology. 2020-01-01; 39.1: 3-7.
PMID: 31851535
Disrupted CXCR2 Signaling in Oligodendroglia Lineage Cells Enhances Myelin Repair in a Viral Model of Multiple Sclerosis.
Journal of virology. 2019-09-15; 93.18:
PMID: 31243125
Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease.
Viral immunology. 2019-01-01; 32.1: 25-37.
PMID: 30109979
Innate Immune Responses and Viral-Induced Neurologic Disease.
Journal of clinical medicine. 2018-12-20; 8.1:
PMID: 30577473
Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment.
European journal of immunology. 2018-07-01; 48.7: 1199-1210.
PMID: 29697856
Understanding brain circuitry changes in opioid use disorder and HIV infection
  • Profiling CNS and peripheral immune cells using snRNAseq, scRNAseq, ATACseq in separate brain regions in opioid and HIV infected clinical tissue
  • Using 3D-Organoid models to study effects of substance abuse on neurons, astrocytes, and oligodendrocytes in vitro