Lina Mastrangelo, PhD

Staff Scientist

Lina Mastrangelo is a staff scientist in Dr. Christine Cheng’s lab at JCVI. Dr. Mastrangelo completed her PhD studies at the University of East Anglia, Norwich, UK, and did her postdoctoral training at the University of California San Diego with Dr. Theodore Friedmann focusing on gene therapy and stem cell studies. She later joined Dr. Evan Snyder’s Lab at the Sanford Burnham Prebys Medical Discovery Institute (SBP) and Sanford Consortium for Regenerative Medicine (SCRM) to continue her research work in stem cells and neurodegenerative medicine.

At JCVI’s La Jolla Campus, Dr. Mastrangelo is using human induced pluripotent stem cells (hiPSCs) to generate 3D organoid culture systems or ‘mini-brains’ to model brain structure and function. She is combining this technology with single-cell analysis to profile the transcriptome of brain organoids derived from Alzheimer’s patients, with the goal of understanding the molecular cause of the disease for the development of new therapies.

Understanding molecular changes in neurodegenerative diseases
  • Develop 3D organoid models for Alzheimer’s disease
  • Utilize single cell transcriptomics to profile brain organoids derived from Alzheimer’s patients

Publications

The Genetics of Parkinson Disease.
Advances in genetics. 2017-09-02; 98.43-62.
PMID: 28942794
Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase.
Proceedings of the National Academy of Sciences of the United States of America. 2012-02-28; 109.9: 3377-82.
PMID: 22331909
Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells.
Cancer research. 2008-07-01; 68.13: 5487-91.
PMID: 18593952
Understanding molecular changes in neurodegenerative diseases
  • Develop 3D organoid models for Alzheimer’s disease
  • Utilize single cell transcriptomics to profile brain organoids derived from Alzheimer’s patients