Bio

Lauren Leone, M.S. is a Staff Scientist at the J. Craig Venter Institute working in the Informatics Department. Ms. Leone’s research is focused on genomics and comparative analysis of bacterial virulence and drug resistance as well as the study of the human microbiome in health and disease and as an evidence type for forensic investigations. Prior to JCVI, Ms. Leone was a Research Supervisor at the Bode Technology Group. She received her M.S. from George Mason University in Bioinformatics and her undergraduate degrees in biology and biochemistry from Syracuse University.

Research Priorities

Genomics and comparative analysis of pathogenic bacteria

  • Emphasis on pathogenicity and antimicrobial resistance mechanisms.

Analysis of human microbiome in health and disease

  • Emphasis on antimicrobial resistance prevalence and transfer, and biomarker discovery.

Application of microbiome technologies for forensic science

  • Emphasis on predictive modeling of forensic indicators.

Bioinformatics tool development and methods improvement

  • Emphasis on bacterial genomics and comparative analyses.
LOCUST: a custom sequence locus typer for classifying microbial isolates.
Bioinformatics (Oxford, England). 2017-06-01; 33.11: 1725-1726.
PMID: 28130240
The Threat of Antimicrobial Resistance on the Human Microbiome.
Microbial ecology. 2017-05-11;
PMID: 28492988
Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease.
Cell metabolism. 2017-05-02; 25.5: 1054-1062.e5.
PMID: 28467925
Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms.
mBio. 2016-12-13; 7.6:
PMID: 27965456
Escherichia coli O-Antigen Gene Clusters of Serogroups O62, O68, O131, O140, O142, and O163: DNA Sequences and Similarity between O62 and O68, and PCR-Based Serogrouping.
Biosensors. 2015-02-05; 5.1: 51-68.
PMID: 25664526
Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.
Antimicrobial agents and chemotherapy. 2014-08-01; 58.8: 4961-5.
PMID: 24913165
Pathogenomic inference of virulence-associated genes in Leptospira interrogans.
PLoS neglected tropical diseases. 2013-01-01; 7.10: e2468.
PMID: 24098822
PanOCT: automated clustering of orthologs using conserved gene neighborhood for pan-genomic analysis of bacterial strains and closely related species.
Nucleic acids research. 2012-12-01; 40.22: e172.
PMID: 22904089
Genetic and phenotypic diversity in Burkholderia: contributions by prophage and phage-like elements.
BMC microbiology. 2010-07-28; 10.202.
PMID: 20667135
The Protein Naming Utility: a rules database for protein nomenclature.
Nucleic acids research. 2010-01-01; 38.Database issue: D336-9.
PMID: 20007151
Genome Properties: a system for the investigation of prokaryotic genetic content for microbiology, genome annotation and comparative genomics.
Bioinformatics (Oxford, England). 2005-02-01; 21.3: 293-306.
PMID: 15347579