Maryann Platt, PhD

Postdoctoral Fellow

Maryann joined JCVI in 2019 working under Dr. Norberto Gonzalez-Juarbe. Her work focuses on co- and secondary infections to elucidate mechanisms behind cell and tissue damage in lungs and heart. Her experience with immune infiltration and neuroimmunology will help her determine the role of immune activation in these processes. Her previous work has shown that S. pyogenes infections lead to neuroinflammation, caveolin-1-mediated breakdown of the blood-brain barrier, and olfactory function deficits.

Originally from Holden, MA, Maryann has a PhD from Columbia University and a BA from Wesleyan University in Middletown, CT. Outside the lab, her favorite pastimes include running, ultimate frisbee, drawing her two cats, and cooking.

Research Priorities

Determine how infection-induced transcriptional dysregulation alters lung function
  • Integrate omics technologies to screen for transcriptional changes
  • Determine cellular and molecular components contributing to changes in epigenetic regulation
Determine mechanisms for cardiac damage after influenza infection
  • Screen for changes in adhesion molecule expression, cardiac muscle function, and immune response molecule expression
  • Determine effects of immune modulation and programmed cell death modulation

Publications

Global proteome and phosphoproteome characterization of sepsis-induced kidney injury.
Molecular & cellular proteomics : MCP. 2020-09-22;
PMID: 32963032
Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis.
Cell reports. 2020-08-25; 32.8: 108062.
PMID: 32846120

Research Priorities

Determine how infection-induced transcriptional dysregulation alters lung function
  • Integrate omics technologies to screen for transcriptional changes
  • Determine cellular and molecular components contributing to changes in epigenetic regulation
Determine mechanisms for cardiac damage after influenza infection
  • Screen for changes in adhesion molecule expression, cardiac muscle function, and immune response molecule expression
  • Determine effects of immune modulation and programmed cell death modulation