Sujal Phadke, PhD

Staff Scientist


858-200-1869

sphadke

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Bio

Sujal Phadke, PhD, is a staff scientist at the J. Craig Venter Institute working in the Microbial and Environmental Genomics group. Dr. Phadke is interested in understanding the evolutionary and molecular mechanisms that shape microbial diversity. This broad interest has led her to use various prokaryotic and eukaryotic models uniquely suited for addressing specific questions in evolutionary biology. Dr. Phadke's research combines experimental evolution, bioinformatics and molecular genetics tools to harness the power of computational and wet-lab approaches for investigating questions at the intersection of microbial evolution, genetics and development.  Prior to her appointment at JCVI, Dr. Phadke did postdoctoral research at the University of Michigan, Ann Arbor and Duke University. She received her PhD from the University of Houston in 2011.

Research Priorities

  • Support development of the IRD and ViPR databases
  • Analysis of host-virus interactions characterized using multi-omics datasets
  • Metagenomics and metatranscriptomics analyses to understand the functional diversity in microbial communities

Projects

Select Publications

Genome-Wide Screen for Saccharomyces cerevisiae Genes Contributing to Opportunistic Pathogenicity in an Invertebrate Model Host.
G3 (Bethesda, Md.). 2018-01-04; 8.1: 63-78.
PMID: 29122853
Harnessing the Power of PCR Molecular Fingerprinting Methods and Next Generation Sequencing for Understanding Structure and Function in Microbial Communities.
Methods in molecular biology (Clifton, N.J.). 2017-01-01; 1602.225-248.
PMID: 28540712
Unisexual reproduction of Cryptococcus gattii.
PloS one. 2014-01-01; 9.6: e111089.
PMID: 25337713
Genetic background alters dominance relationships between mat alleles in the ciliate Tetrahymena thermophila.
The Journal of heredity. 2014-01-01; 105.1: 130-5.
PMID: 24190504
Unisexual reproduction enhances fungal competitiveness by promoting habitat exploration via hyphal growth and sporulation.
Eukaryotic cell. 2013-08-01; 12.8: 1155-9.
PMID: 23794511
Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii.
PLoS genetics. 2013-01-01; 9.9: e1003771.
PMID: 24039607
Cryptococcus gattii, no longer an accidental pathogen?
Current fungal infection reports. 2012-12-01; 6.4: 245-256.
PMID: 23243480
Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases.
Eukaryotic cell. 2012-11-01; 11.11: 1391-8.
PMID: 23002105
Is Evolution of Mating Preferences Inevitable? Random Mating in the Multisex System of Tetrahymena thermophila.
International journal of evolutionary biology. 2012-01-01; 2012.201921.
PMID: 23056994
Sex ratio evolution under probabilistic sex determination.
Evolution; international journal of organic evolution. 2011-07-01; 65.7: 2050-60.
PMID: 21729059