Yanbao Yu, PhD

Assistant Professor
301-795-7868

Yanbao Yu is an Assistant Professor in the Department of Infectious Disease. His research laboratory aims to study fundamental questions associated with host-microbe interactions, bacterial pathogenesis, and cell signaling in innate immunity by employing innovative technologies centered on high throughput high accuracy mass spectrometry (MS)-based quantitative proteomics.

He joined JCVI in 2013, first as postdoctoral fellow, and later as Staff Scientist with research focused on urinary tract infections and catheter biofilms. He became an independent investigator in November 2017, with broad research interests in microbiome and metaproteomics.

He obtained his PhD in chemical biology from Fudan University, Shanghai.

Research Priorities

Study of human microbiome and their participation in health and diseases.
  • MS-based microbial detection as potential clinical diagnostic methods
  • Mechanism of host-microbe interactions in infectious diseases
  • Chemical biology approaches to investigate protein interactions
  • Integration of multiple omics
Development of novel MS-based techniques for highly efficient and effective proteome analysis
  • Alternative protein/peptide fractionation and identification methods
  • Large scale clinical/microbial sample processing for biomarker discovery
  • Label-based and label-free proteome quantitation technologies

Publications

Torralba MG, Aleti G, Li W, Moncera KJ, Lin YH, Yu Y, Masternak MM, Golusinski W, Golusinski P, Lamperska K, Edlund A, Freire M, Nelson KE
Oral Microbial Species and Virulence Factors Associated with Oral Squamous Cell Carcinoma.
Microbial ecology. 2020-11-06;
PMID: 33155101
Yu Y, Singh H, Kwon K, Tsitrin T, Petrini J, Nelson KE, Pieper R
Protein signatures from blood plasma and urine suggest changes in vascular function and IL-12 signaling in elderly with a history of chronic diseases compared with an age-matched healthy cohort.
GeroScience. 2020-09-24;
PMID: 32974878
Yu Y, O'Rourke A, Lin YH, Singh H, Eguez RV, Beyhan S, Nelson KE
Predictive Signatures of 19 Antibiotic-Induced Escherichia coli Proteomes.
ACS infectious diseases. 2020-08-14; 6.8: 2120-2129.
PMID: 32673475
Lin YH, Eguez RV, Torralba MG, Singh H, Golusinski P, Goliusinski W, Golusinski W, Masternak M, Nelson KE, Freire M, Yu Y
Self-Assembled STrap for Global Proteomics and Salivary Biomarker Discovery.
Journal of proteome research. 2019-04-05; 18.4: 1907-1915.
PMID: 30848925
Moustafa A, Li W, Singh H, Moncera KJ, Torralba MG, Yu Y, Manuel O, Biggs W, Venter JC, Nelson KE, Pieper R, Telenti A
Microbial metagenome of urinary tract infection.
Scientific reports. 2018-03-12; 8.1: 4333.
PMID: 29531289
Yu Y, Bekele S, Pieper R
Quick 96FASP for high throughput quantitative proteome analysis.
Journal of proteomics. 2017-08-23; 166.1-7.
PMID: 28669814
Singh H, Yu Y, Suh MJ, Torralba MG, Stenzel RD, Tovchigrechko A, Thovarai V, Harkins DM, Rajagopala SV, Osborne W, Cogen FR, Kaplowitz PB, Nelson KE, Madupu R, Pieper R
Type 1 Diabetes: Urinary Proteomics and Protein Network Analysis Support Perturbation of Lysosomal Function.
Theranostics. 2017-07-07; 7.10: 2704-2717.
PMID: 28819457
Yu Y, Kwon K, Tsitrin T, Bekele S, Sikorski P, Nelson KE, Pieper R
Characterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections.
PLoS pathogens. 2017-01-27; 13.1: e1006151.
PMID: 28129394
Yu Y, Sikorski P, Smith M, Bowman-Gholston C, Cacciabeve N, Nelson KE, Pieper R
Comprehensive Metaproteomic Analyses of Urine in the Presence and Absence of Neutrophil-Associated Inflammation in the Urinary Tract.
Theranostics. 2017-01-01; 7.2: 238-252.
PMID: 28042331
Yu Y, Zielinski MD, Rolfe MA, Kuntz MM, Nelson H, Nelson KE, Pieper R
Similar Neutrophil-Driven Inflammatory and Antibacterial Responses in Elderly Patients with Symptomatic and Asymptomatic Bacteriuria.
Infection and immunity. 2015-10-01; 83.10: 4142-53.
PMID: 26238715
Yu Y, Sikorski P, Bowman-Gholston C, Cacciabeve N, Nelson KE, Pieper R
Diagnosing inflammation and infection in the urinary system via proteomics.
Journal of translational medicine. 2015-04-08; 13.111.
PMID: 25889401
Yu Y, Pieper R
Urine sample preparation in 96-well filter plates to characterize inflammatory and infectious diseases of the urinary tract.
Advances in experimental medicine and biology. 2015-01-01; 883.77-87.
PMID: 25355571
Yu Y, Pieper R
Urinary pellet sample preparation for shotgun proteomic analysis of microbial infection and host-pathogen interactions.
Methods in molecular biology (Clifton, N.J.). 2015-01-01; 1295.65-74.
PMID: 25820714
Yu Y, Suh MJ, Sikorski P, Kwon K, Nelson KE, Pieper R
Urine sample preparation in 96-well filter plates for quantitative clinical proteomics.
Analytical chemistry. 2014-06-03; 86.11: 5470-7.
PMID: 24797144

Research Priorities

Study of human microbiome and their participation in health and diseases.
  • MS-based microbial detection as potential clinical diagnostic methods
  • Mechanism of host-microbe interactions in infectious diseases
  • Chemical biology approaches to investigate protein interactions
  • Integration of multiple omics
Development of novel MS-based techniques for highly efficient and effective proteome analysis
  • Alternative protein/peptide fractionation and identification methods
  • Large scale clinical/microbial sample processing for biomarker discovery
  • Label-based and label-free proteome quantitation technologies

Gut Microbiome Sysbiosis in Childhood Acute Lymphoblastic Leukemia (ALL) Patients

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Genomics and Proteomics Approaches to T1D

This study addresses the complex interactions between the host and environmental factors as they relate to the development of Type I Diabetes (T1D). 

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