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Yanbao Yu, PhD, is an Assistant Professor at the J. Craig Venter Institute working in the Department of Infectious Disease. His research laboratory aims to study fundamental questions associated with host-microbe interactions, bacterial pathogenesis, and cell signaling in innate immunity by employing innovative technologies centered on high throughput high accuracy mass spectrometry (MS)-based quantitative proteomics. He obtained his PhD in chemical biology from Fudan University, Shanghai. He joined JCVI in 2013, first as postdoctoral fellow, and later as Staff Scientist with research focused on urinary tract infections and catheter biofilms. He became an independent investigator in November 2017, with broad research interests in microbiome and metaproteomics.

Research Priorities

Study of human microbiome and their participation in health and diseases.

  • MS-based microbial detection as potential clinical diagnostic methods
  • Mechanism of host-microbe interactions in infectious diseases
  • Chemical biology approaches to investigate protein interactions
  • Integration of multiple omics

Development of novel MS-based techniques for highly efficient and effective proteome analysis

  • Alternative protein/peptide fractionation and identification methods
  • Large scale clinical/microbial sample processing for biomarker discovery
  • Label-based and label-free proteome quantitation technologies


Select Publications

Quick 96FASP for high throughput quantitative proteome analysis.
Journal of proteomics. 2017-08-23; 166.1-7.
PMID: 28669814
Comprehensive Metaproteomic Analyses of Urine in the Presence and Absence of Neutrophil-Associated Inflammation in the Urinary Tract.
Theranostics. 2017-01-01; 7.10: 238-252.
PMID: 28042331
Characterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections.
PLoS pathogens. 2017-01-01; 13.1: e1006151.
PMID: 28129394
Similar Neutrophil-Driven Inflammatory and Antibacterial Responses in Elderly Patients with Symptomatic and Asymptomatic Bacteriuria.
Infection and immunity. 2015-10-01; 83.10: 4142-53.
PMID: 26238715
Diagnosing inflammation and infection in the urinary system via proteomics.
Journal of translational medicine. 2015-04-08; 13.111.
PMID: 25889401
Urine sample preparation in 96-well filter plates to characterize inflammatory and infectious diseases of the urinary tract.
Advances in experimental medicine and biology. 2015-01-01; 883.77-87.
PMID: 25355571
Urinary pellet sample preparation for shotgun proteomic analysis of microbial infection and host-pathogen interactions.
Methods in molecular biology (Clifton, N.J.). 2015-01-01; 1275.65-74.
PMID: 25820714
Urine sample preparation in 96-well filter plates for quantitative clinical proteomics.
Analytical chemistry. 2014-06-03; 86.11: 5470-7.
PMID: 24797144