Autoimmune Diseases


Autoimmune diseases are a family of over 80 chronic, disabling illnesses in which defects in the immune system leads the body to attack normal components (self-antigens) of its own tissues. Autoimmune diseases affect 14.7 – 23.5 million people in the U.S. alone (5 – 8%), making it one of the most common classes of human diseases. However, despite several decades of research being devoted to understanding autoimmunity, a coherent explanation of the critical causative events that initiate the autoimmune response is still lacking. JCVI is attacking this problem by applying cutting-edge genomics, bioinformatics and machine learning approaches to discover the causes of autoimmunity and develop novel therapeutic approaches to alleviate and cure these diseases.