The Center for Structural Genomics of Infectious Diseases

The Center for Structural Genomics of Infectious Diseases

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The JCVI has been a consortium member of the Center for Structural Genomics of Infectious Disease (CSGID) sponsored by the National Institute for Allergy and Infectious Disease (NIAID) since 2007. The Center's mission is to solve the three-dimensional structure of proteins from pathogens in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases. The targeted proteins are those with an important biological role or potential targets for vaccine and drug development.

The JCVI CSGID team has developed a high-throughput (HTP) cloning and protein expression pipeline to screen protein candidates for downstream scaled-up expression, protein purification and ultimately HTP structural determination. Clones yielding expressed, soluble protein are transferred to our consortium members who in turn apply state-of-the-art HTP structural biology technologies to experimentally determine the three-dimensional atomic structure. The three-dimensional structure of proteins will assist drug design and development by yielding direct insights into the target molecular mechanisms for interaction with other biological molecules or with synthetic compounds, in order to improve selectivity, specificity and optimize drug development in a rational way.

An individual or collaborative group of investigators interested in proposing a target for protein structure determination at the CSGID can submit a proposal to CSGID through www.csgid.org.

Available Organisms

Viruses

Taxon ID

Cowpox virus (Brighton Red)

265872

Dengue virus 1

11053

Dengue virus 2

11060

Dengue virus 3

11069

Dengue virus 4

11070

Human herpesvirus 6

10368

Monkeypox virus

10244

Myxoma virus (strain Lausanne)

31530

Influenza virus A

197911

Prokaryotes

Taxon ID

Acinetobacter baumannii ATCC 17978

400667

Actinobacillus pleuropneumoniae

228399

Bacillus anthracis str. Ames

198094

Bacillus anthracis str. Sterne

260799

Bacillus cereus ATCC 10987

222523

Bacillus cereus ATCC 14579

226900

Bacillus subtilis subsp. subtilis str. 168

224308

Bacteroides thetaiotaomicron VPI-5482

226186

Bifidobacterium infantis Reuter

391904

Bordetella pertussis Tohama I

257313

Borrelia burgdorferi B31

224326

Burkholderia mallei ATCC 23344

243160

Campylobacter jejuni subsp. jejuni NCTC 11168

192222

Chlamydia muridarum MoPn Nigg II

243161

Chlamydia trachomatis D/UW-3/CX

272561

Chlamydia trachomatis D/UW-3/CX

272561

Clostridium difficile 630

272563

Clostridium perfringens ATCC 13124

195103

Cowpox virus Brighton Red

265872

Coxiella burnetii RSA 493

227377

Enterococcus faecinum TEX16, TX0016

333849

Enterococcus faecalis V583

226185

Escherichia coli 042

216592

Escherichia coli CFT073

199310

Escherichia coli ETEC H10407

316401

Escherichia coli K12 substr. MG1655

511145

Escherichia coli O157:H7 EDL933

155864

Escherichia coli O157:H7 str. Sakai

386585

Escherichia coli UTI89

364106

Francisella tularensis subsp. tularensis SCHU S4

177416

Haemophilus influenzae PittII

374933

Helicobacter pylori 26695

85962

Helicobacter pylori Str RPH 13487

102618

Helicobacter pylori J99

85963

Legionella pneumophila susp.pneumophila str.Philadelphia 1

272624

Listeria monocytogenes 1/2a F6854

267409

Listeria monocytogenes EGD-e

169963

Listeria monocytogenes str. 4b F2365

265669

Listeria monocytogenes str. 4b H7858

267410

Mycobacterium smegmatis str. MC2 155

246196

Mycobacterium tuberculosis CDC1551

83331

Mycobacterium tuberculosis H37Rv

83332

Neisseria gonorrhoeae FA 1090

242231

Neisseria meningitidis MC58

122586

Pseudomonas aeruginosa PA14

652611

Pseudomonas aeruginosa PAO1

208964

Pseudomonas fluorescens Pf-5

220664

Pseudomonas putida KT2440

160488

Rickettsia prowazekii str. Madrid E

272947

Rhizobium radiobacter/Agrobacterium tumefaciens str C58

176299

Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150

295319

Salmonella enterica subsp. enterica serovar Typhi str. CT18

220341

Salmonella enterica subsp. enterica serovar Typhi Ty2

209261

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

99287

Shigella flexneri 2a str. 2457T

198215

Staphylococcus aureus Strain FPR3757

451515

Staphylococcus aureus subsp. aureus COL

93062

Staphylococcus aureus subsp. aureus MRSA252

282458

Staphylococcus aureus subsp. aureus 923

875057

Staphylococcus aureus subsp. aureus Mu3

418127

Staphylococcus aureus subsp. aureus Mu50

158878

Staphylococcus aureus subsp. aureus MW2

196620

Staphylococcus aureus substp.aureus N315

1558879

Staphylococcus aureus substp.aureus NCTC 8325

93061

Staphylococcus epidermidis RP62A

176279

Streptococcus agalactiae Str A909

205921

Streptococcus agalactiae 2603V/R

208435

Streptococcus mutants UA 159

210007

Streptococcus pneumoniae G54

512566

Streptococcus pneumoniae R6

171101

Streptococcus pneumoniae TIGR4

170187

Streptococcus pyogenes Strain NZ131

471876

Streptococcus pyogenes MGAS5005

293653

Streptococcus salivarius subsp. thermophilus Strain LMD-9

322159

Streptococcus thermophilus LMG18311

264199

Vibrio cholerae O1 biovar El Tor str. N16961

243277

Vibrio cholerae O395

345073

Vibrio fischeri ES114

312309

Vibrio parahaemolyticus EB101

670

Vibrio parahaemolyticus RIMD 2210633

223926

Vibrio vulnificus CMCP6

216895

Yersinia enterocolitica str 8081

393305

Yersinia pestis CO92

214092

Yersinia pestis KIM

187410

Yersinia pseudotuberculosis IP 32953

273123

Funding

This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272200700058C and HHSN272201200026C.