Cheng CS, Johnson TL, Hoffmann A
Epigenetic control: slow and global, nimble and local.
Genes & development. 2008-05-01; 22.9: 1110-4.
The regulation of gene expression involves multiple levels of control, from those that are inheritable to those that are highly responsive to environmental changes. In this issue of Genes & Development, Dong and colleagues (pp. 1159-1173) demonstrate that the dynamically controlled immune response transcription factor NF-kappaB may, in fact, have a role in regulating heterochromatin and gene expression at large distances from its actual target sequences and genes.
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