First Report of the Carbapenemase Gene blaOXA-499 in Acinetobacter pittii.

First Report of the Carbapenemase Gene blaOXA-499 in Acinetobacter pittii.

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Authors: D'Souza R, Pinto NA, Higgins PG, Hwang I, Yong D, Choi J, Lee K, Chong Y
Title: First Report of the Carbapenemase Gene blaOXA-499 in Acinetobacter pittii.
Citation: Antimicrobial agents and chemotherapy. 2017-05-01; 61.5: .
Abstract:
We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.
PMID: 28264850

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