Human Health & Performance

A healthy, optimal life that enables individuals to achieve their personal potential is the goal for us all. Genetics, combined with different environmental interactions, makes every individual unique and the current one-size-fits-all medical solutions, inadequate. Building upon genomic expertise at JCVI, the Center for Human Performance aims to widen our understanding of how individualized markers affect human performance, traits and diseases. Utilizing advanced science and artificial intelligence approaches, we will identify key markers that enable optimal living, as well as risk factors for disease. It is our belief that this research will contribute to advancing the understanding of human health, and will enhance lives beyond managing health risks.

Publications

Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging.
Proceedings of the National Academy of Sciences of the United States of America. 2020-01-24;
PMID: 31980526
An unsupervised learning approach to identify novel signatures of health and disease from multimodal data.
Genome medicine. 2020-01-10; 12.1: 7.
PMID: 31924279
Functional characterization of 3D protein structures informed by human genetic diversity.
Proceedings of the National Academy of Sciences of the United States of America. 2019-04-30; 116.18: 8960-8965.
PMID: 30988206
Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders.
European journal of human genetics : EJHG. 2019-01-01; 27.1: 150-159.
PMID: 30254217
Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk.
Cell metabolism. 2018-10-08;
PMID: 30318341
The fecal metabolome as a functional readout of the gut microbiome.
Nature genetics. 2018-06-01; 50.6: 790-795.
PMID: 29808030
Identification of Misclassified ClinVar Variants via Disease Population Prevalence.
American journal of human genetics. 2018-04-05; 102.4: 609-619.
PMID: 29625023
Comparison of phasing strategies for whole human genomes.
PLoS genetics. 2018-04-05; 14.4: e1007308.
PMID: 29621242
Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults.
Proceedings of the National Academy of Sciences of the United States of America. 2018-04-03; 115.14: 3686-3691.
PMID: 29555771
Microbial metagenome of urinary tract infection.
Scientific reports. 2018-03-12; 8.1: 4333.
PMID: 29531289
The human noncoding genome defined by genetic diversity.
Nature genetics. 2018-03-01; 50.3: 333-337.
PMID: 29483654
Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones.
EBioMedicine. 2018-02-01;
PMID: 29398597
Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease.
Clinical and translational gastroenterology. 2018-01-18; 9.1: e132.
PMID: 29345635
Human gene essentiality.
Nature reviews. Genetics. 2018-01-01; 19.1: 51-62.
PMID: 29082913
Identification of individuals by trait prediction using whole-genome sequencing data.
Proceedings of the National Academy of Sciences of the United States of America. 2017-09-19; 114.38: 10166-10171.
PMID: 28874526
Fast and accurate HLA typing from short-read next-generation sequence data with xHLA.
Proceedings of the National Academy of Sciences of the United States of America. 2017-07-25; 114.30: 8059-8064.
PMID: 28674023
Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease.
Cell metabolism. 2017-05-02; 25.5: 1054-1062.e5.
PMID: 28467925
Utilization of defined microbial communities enables effective evaluation of meta-genomic assemblies.
BMC genomics. 2017-04-13; 18.1: 296.
PMID: 28407798
Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites.
Nature genetics. 2017-04-01; 49.4: 568-578.
PMID: 28263315
The Human Microbiome and Cancer.
Cancer prevention research (Philadelphia, Pa.). 2017-04-01; 10.4: 226-234.
PMID: 28096237
The blood DNA virome in 8,000 humans.
PLoS pathogens. 2017-03-22; 13.3: e1006292.
PMID: 28328962
Establishing the involvement of the novel gene AGBL5 in retinitis pigmentosa by whole genome sequencing.
Physiological genomics. 2016-12-01; 48.12: 922-927.
PMID: 27764769
Deep sequencing of 10,000 human genomes.
Proceedings of the National Academy of Sciences of the United States of America. 2016-10-18; 113.42: 11901-11906.
PMID: 27702888
A robust ambient temperature collection and stabilization strategy: Enabling worldwide functional studies of the human microbiome.
Scientific reports. 2016-08-25; 6.31731.
PMID: 27558918
Dynamics of an Aging Genome.
Cell metabolism. 2016-06-14; 23.6: 949-950.
PMID: 27304490
Library preparation methodology can influence genomic and functional predictions in human microbiome research.
Proceedings of the National Academy of Sciences of the United States of America. 2015-11-10; 112.45: 14024-9.
PMID: 26512100

This project is currently seeking a funding partner. Please contact the JCVI Development Office

Jill Mullen
Sr. Vice President of Philanthropy and Strategic Alliances

jmullen@jcvi.org

858-200-1885