Human Health & Performance

A healthy, optimal life that enables individuals to achieve their personal potential is the goal for us all. Genetics, combined with different environmental interactions, makes every individual unique and the current one-size-fits-all medical solutions, inadequate. Building upon genomic expertise at JCVI, the Center for Human Performance aims to widen our understanding of how individualized markers affect human performance, traits and diseases. Utilizing advanced science and artificial intelligence approaches, we will identify key markers that enable optimal living, as well as risk factors for disease. It is our belief that this research will contribute to advancing the understanding of human health, and will enhance lives beyond managing health risks.

Principal Investigator

Key Staff

Related Research

Publications

Hou YC, Yu HC, Martin R, Cirulli ET, Schenker-Ahmed NM, Hicks M, Cohen IV, Jönsson TJ, Heister R, Napier L, Swisher CL, Dominguez S, Tang H, Li W, Perkins BA, Barea J, Rybak C, Smith E, Duchicela K, Doney M, Brar P, Hernandez N, Kirkness EF, Kahn AM, Venter JC, Karow DS, Caskey CT
Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging.
Proceedings of the National Academy of Sciences of the United States of America. 2020-02-11; 117.6: 3053-3062.
PMID: 31980526
Shomorony I, Cirulli ET, Huang L, Napier LA, Heister RR, Hicks M, Cohen IV, Yu HC, Swisher CL, Schenker-Ahmed NM, Li W, Nelson KE, Brar P, Kahn AM, Spector TD, Caskey CT, Venter JC, Karow DS, Kirkness EF, Shah N
An unsupervised learning approach to identify novel signatures of health and disease from multimodal data.
Genome medicine. 2020-01-10; 12.1: 7.
PMID: 31924279
Hicks M, Bartha I, di Iulio J, Venter JC, Telenti A
Functional characterization of 3D protein structures informed by human genetic diversity.
Proceedings of the National Academy of Sciences of the United States of America. 2019-04-30; 116.18: 8960-8965.
PMID: 30988206
Cirulli ET, Guo L, Leon Swisher C, Shah N, Huang L, Napier LA, Kirkness EF, Spector TD, Caskey CT, Thorens B, Venter JC, Telenti A
Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk.
Cell metabolism. 2019-02-05; 29.2: 488-500.e2.
PMID: 30318341
Iranmehr A, Stobdan T, Zhou D, Poulsen O, Strohl KP, Aldashev A, Telenti A, Wong EHM, Kirkness EF, Venter JC, Bafna V, Haddad GG
Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders.
European journal of human genetics : EJHG. 2019-01-01; 27.1: 150-159.
PMID: 30254217
Zierer J, Jackson MA, Kastenmüller G, Mangino M, Long T, Telenti A, Mohney RP, Small KS, Bell JT, Steves CJ, Valdes AM, Spector TD, Menni C
The fecal metabolome as a functional readout of the gut microbiome.
Nature genetics. 2018-06-01; 50.6: 790-795.
PMID: 29808030
Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J
Paternally inherited cis-regulatory structural variants are associated with autism.
Science (New York, N.Y.). 2018-04-20; 360.6386: 327-331.
PMID: 29674594
Shah N, Hou YC, Yu HC, Sainger R, Caskey CT, Venter JC, Telenti A
Identification of Misclassified ClinVar Variants via Disease Population Prevalence.
American journal of human genetics. 2018-04-05; 102.4: 609-619.
PMID: 29625023
Choi Y, Chan AP, Kirkness E, Telenti A, Schork NJ
Comparison of phasing strategies for whole human genomes.
PLoS genetics. 2018-04-05; 14.4: e1007308.
PMID: 29621242
Perkins BA, Caskey CT, Brar P, Dec E, Karow DS, Kahn AM, Hou YC, Shah N, Boeldt D, Coughlin E, Hands G, Lavrenko V, Yu J, Procko A, Appis J, Dale AM, Guo L, Jönsson TJ, Wittmann BM, Bartha I, Ramakrishnan S, Bernal A, Brewer JB, Brewerton S, Biggs WH, Turpaz Y, Venter JC
Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults.
Proceedings of the National Academy of Sciences of the United States of America. 2018-04-03; 115.14: 3686-3691.
PMID: 29555771
Moustafa A, Li W, Singh H, Moncera KJ, Torralba MG, Yu Y, Manuel O, Biggs W, Venter JC, Nelson KE, Pieper R, Telenti A
Microbial metagenome of urinary tract infection.
Scientific reports. 2018-03-12; 8.1: 4333.
PMID: 29531289
di Iulio J, Bartha I, Wong EHM, Yu HC, Lavrenko V, Yang D, Jung I, Hicks MA, Shah N, Kirkness EF, Fabani MM, Biggs WH, Ren B, Venter JC, Telenti A
The human noncoding genome defined by genetic diversity.
Nature genetics. 2018-03-01; 50.3: 333-337.
PMID: 29483654
Cohen IV, Cirulli ET, Mitchell MW, Jonsson TJ, Yu J, Shah N, Spector TD, Guo L, Venter JC, Telenti A
Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones.
EBioMedicine. 2018-02-15; 28.316-323.
PMID: 29398597
Moustafa A, Li W, Anderson EL, Wong EHM, Dulai PS, Sandborn WJ, Biggs W, Yooseph S, Jones MB, Venter JC, Nelson KE, Chang JT, Telenti A, Boland BS
Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease.
Clinical and translational gastroenterology. 2018-01-18; 9.1: e132.
PMID: 29345635
Bartha I, di Iulio J, Venter JC, Telenti A
Human gene essentiality.
Nature reviews. Genetics. 2018-01-01; 19.1: 51-62.
PMID: 29082913
Lippert C, Sabatini R, Maher MC, Kang EY, Lee S, Arikan O, Harley A, Bernal A, Garst P, Lavrenko V, Yocum K, Wong T, Zhu M, Yang WY, Chang C, Lu T, Lee CWH, Hicks B, Ramakrishnan S, Tang H, Xie C, Piper J, Brewerton S, Turpaz Y, Telenti A, Roby RK, Och FJ, Venter JC
Identification of individuals by trait prediction using whole-genome sequencing data.
Proceedings of the National Academy of Sciences of the United States of America. 2017-09-19; 114.38: 10166-10171.
PMID: 28874526
Xie C, Yeo ZX, Wong M, Piper J, Long T, Kirkness EF, Biggs WH, Bloom K, Spellman S, Vierra-Green C, Brady C, Scheuermann RH, Telenti A, Howard S, Brewerton S, Turpaz Y, Venter JC
Fast and accurate HLA typing from short-read next-generation sequence data with xHLA.
Proceedings of the National Academy of Sciences of the United States of America. 2017-07-25; 114.30: 8059-8064.
PMID: 28674023
Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE
Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease.
Cell metabolism. 2017-05-02; 25.5: 1054-1062.e5.
PMID: 28467925
Greenwald WW, Klitgord N, Seguritan V, Yooseph S, Venter JC, Garner C, Nelson KE, Li W
Utilization of defined microbial communities enables effective evaluation of meta-genomic assemblies.
BMC genomics. 2017-04-13; 18.1: 296.
PMID: 28407798
Rajagopala SV, Vashee S, Oldfield LM, Suzuki Y, Venter JC, Telenti A, Nelson KE
The Human Microbiome and Cancer.
Cancer prevention research (Philadelphia, Pa.). 2017-04-01; 10.4: 226-234.
PMID: 28096237
Long T, Hicks M, Yu HC, Biggs WH, Kirkness EF, Menni C, Zierer J, Small KS, Mangino M, Messier H, Brewerton S, Turpaz Y, Perkins BA, Evans AM, Miller LA, Guo L, Caskey CT, Schork NJ, Garner C, Spector TD, Venter JC, Telenti A
Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites.
Nature genetics. 2017-04-01; 49.4: 568-578.
PMID: 28263315
Moustafa A, Xie C, Kirkness E, Biggs W, Wong E, Turpaz Y, Bloom K, Delwart E, Nelson KE, Venter JC, Telenti A
The blood DNA virome in 8,000 humans.
PLoS pathogens. 2017-03-22; 13.3: e1006292.
PMID: 28328962
Branham K, Matsui H, Biswas P, Guru AA, Hicks M, Suk JJ, Li H, Jakubosky D, Long T, Telenti A, Nariai N, Heckenlively JR, Frazer KA, Sieving PA, Ayyagari R
Establishing the involvement of the novel gene AGBL5 in retinitis pigmentosa by whole genome sequencing.
Physiological genomics. 2016-12-01; 48.12: 922-927.
PMID: 27764769
Telenti A, Pierce LC, Biggs WH, di Iulio J, Wong EH, Fabani MM, Kirkness EF, Moustafa A, Shah N, Xie C, Brewerton SC, Bulsara N, Garner C, Metzker G, Sandoval E, Perkins BA, Och FJ, Turpaz Y, Venter JC
Deep sequencing of 10,000 human genomes.
Proceedings of the National Academy of Sciences of the United States of America. 2016-10-18; 113.42: 11901-11906.
PMID: 27702888
Anderson EL, Li W, Klitgord N, Highlander SK, Dayrit M, Seguritan V, Yooseph S, Biggs W, Venter JC, Nelson KE, Jones MB
A robust ambient temperature collection and stabilization strategy: Enabling worldwide functional studies of the human microbiome.
Scientific reports. 2016-08-25; 6.31731.
PMID: 27558918
Abeles SR, Jones MB, Santiago-Rodriguez TM, Ly M, Klitgord N, Yooseph S, Nelson KE, Pride DT
Microbial diversity in individuals and their household contacts following typical antibiotic courses.
Microbiome. 2016-07-30; 4.1: 39.
PMID: 27473422
Telenti A, Perkins BA, Venter JC
Dynamics of an Aging Genome.
Cell metabolism. 2016-06-14; 23.6: 949-950.
PMID: 27304490
Jones MB, Highlander SK, Anderson EL, Li W, Dayrit M, Klitgord N, Fabani MM, Seguritan V, Green J, Pride DT, Yooseph S, Biggs W, Nelson KE, Venter JC
Library preparation methodology can influence genomic and functional predictions in human microbiome research.
Proceedings of the National Academy of Sciences of the United States of America. 2015-11-10; 112.45: 14024-9.
PMID: 26512100

Principal Investigator

Key Staff

Related Research

This project is currently seeking a funding partner. Please contact the JCVI Development Office

Jill Mullen
Sr. Vice President of Philanthropy and Strategic Alliances

jmullen@jcvi.org

858-200-1885