A Study of the Relationship Between the Oral Microbiome and Caries Status of Young Twins

A Study of the Relationship Between the Oral Microbiome and Caries Status of Young Twins

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Host genetics and environmental factors have a significant impact on the oral microbiome. However, such external factors influencing the oral microbiome have yet to be investigated thoroughly using meta-omics approaches. Our study focuses on determining the links between early environment (shared and nonshared), genetics, epigenetics, and caries development. Our goals include characterizing the species and strains of dental plaque collected from twin pairs during a longitudinal study, characterizing the functional component of these samples with metagenomics and metatranscriptomics sequencing, and determining the link between host genetics and caries development—particularly in caries concordant and discordant twins.

Host Genetic Control of the Oral Microbiome in Health and Disease.
Cell host & microbe. 2017-09-13; 22.3: 269-278.e3.
PMID: 28910633
The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health.
Microbial ecology. 2017-02-01; 73.2: 492-503.
PMID: 27628595

Funding for this project provided through the National Institute of Dental and Craniofacial Research (NIDCR).