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TIGRFAMs is a database of protein family definitions. Each entry features a seed alignment of trusted representative sequences, a hidden Markov model (HMM) built from that alignment, cutoff scores that let automated annotation pipelines decide which proteins are members, and annotations for transfer onto member proteins. Most TIGRFAMs models are designated equivalog, meaning they assign a specific name to proteins conserved in function from a common ancestral sequence. Models describing more functionally heterogeneous families are designated subfamily or domain, and assign less specific but more widely applicable annotations.

The Genome Properties database specifies how computed evidence, including TIGRFAMs HMM results, should be used to judge whether an enzymatic pathway, a protein complex or another type of molecular subsystem is encoded in a genome. TIGRFAMs and Genome Properties content are developed in concert because subsystems reconstruction for large numbers of genomes guides selection of seed alignment sequences and cutoff values during protein family construction. Both databases specialize heavily in bacterial and archaeal subsystems. Content derives both from subsystem discovery work and from biocuration of the scientific literature.

To cite the TIGRFAMs resource, please reference "TIGRFAMs: a protein family resource for the functional identification of proteins."

A comprehensive software suite for protein family construction and functional site prediction.
PloS one. 2017-01-01; 12.6: e0171758.
PMID: 28182651
TIGRFAMs and Genome Properties in 2013.
Nucleic acids research. 2013-01-01; 41.Database issue: D387-95.
PMID: 23197656
TIGRFAMs and Genome Properties: tools for the assignment of molecular function and biological process in prokaryotic genomes.
Nucleic acids research. 2007-01-01; 35.Database issue: D260-4.
PMID: 17151080
The TIGRFAMs database of protein families.
Nucleic acids research. 2003-01-01; 31.1: 371-3.
PMID: 12520025
HMM-based databases in InterPro.
Briefings in bioinformatics. 2002-09-01; 3.3: 236-45.
PMID: 12230032
TIGRFAMs: a protein family resource for the functional identification of proteins.
Nucleic acids research. 2001-01-01; 29.1: 41-3.
PMID: 11125044

This project was funded through National Science Foundation (NSF), grant number 1458808.