Journal of hepatology. 2012-06-01; 56.6: 1283-92.

Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease

Fouts DE, Torralba M, Nelson KE, Brenner DA, Schnabl B

PMID: 22326468


Intestinal dysbiosis and bacterial translocation are common in patients with advanced liver disease, and there is strong evidence that the translocation of bacteria and their products across the epithelial barrier drives experimental liver disease progression. The aims of our study were to investigate dynamics of bacterial translocation and changes in the enteric microbiome in early stages of liver disease.