Publications

European urology oncology. 2026-08-07;

Detection and Localization of Unfavorable-histology Prostate Cancer Using MRI and Whole-mount Histopathology

Rojo Domingo M, Dornisch A, Conlin CC, Bagrodia A, Barrett T, Cooperberg M, Desloges JJ, Do DD, Do S, Hahn ME, Harisinghani M, Hollenberg G, Kallis K, Kane CJ, Kim J, Lee KL, Levine J, Liss MA, Liu J, Nakrour N, Osinski T, Pare C, Rakow-Penner R, Rupareliya R, Salmasi A, Simko J, Song Y, Sushentev N, Weinberg E, Woolen S, Dale AM, Shabaik AS, Seibert TM

PMID: 42567735

Abstract

Detecting localized prostate cancer (PC) with metastatic potential-defined as unfavorable-histology PC (uhPC), comprising Grade Group (GG) ≥3 disease or GG 2 disease with cribriform/intraductal features-is critical for guiding appropriate intervention. We evaluated the utility of the Prostate Imaging Reporting and Data System (PI-RADS) and the automated Restriction Spectrum Imaging restriction score (RSIrs; a biophysics-based quantitative MRI biomarker) for uhPC detection and localization.

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