Yooseph S, Li W, Sutton G
Gene identification and protein classification in microbial metagenomic sequence data via incremental clustering.
BMC bioinformatics. 2008-04-10; 9.182.
The identification and study of proteins from metagenomic datasets can shed light on the roles and interactions of the source organisms in their communities. However, metagenomic datasets are characterized by the presence of organisms with varying GC composition, codon usage biases etc., and consequently gene identification is challenging. The vast amount of sequence data also requires faster protein family classification tools.