Biology direct. 2006-10-26; 1.34.

Long intervals of stasis punctuated by bursts of positive selection in the seasonal evolution of influenza A virus

Wolf YI, Viboud C, Holmes EC, Koonin EV, Lipman DJ

PMID: 17067369


The interpandemic evolution of the influenza A virus hemagglutinin (HA) protein is commonly considered a paragon of rapid evolutionary change under positive selection in which amino acid replacements are fixed by virtue of their effect on antigenicity, enabling the virus to evade immune surveillance.

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