Manenzhe RI, Dube FS, Wright M, Lennard K, Zar HJ, Mounaud S, Nierman WC, Nicol MP, Moodley C
Longitudinal changes in the nasopharyngeal resistome of South African infants using shotgun metagenomic sequencing.
PloS one. 2020-04-22; 15.4: e0231887.
Nasopharyngeal (NP) colonization with antimicrobial-resistant bacteria is a global public health concern. Antimicrobial-resistance (AMR) genes carried by the resident NP microbiota may serve as a reservoir for transfer of resistance elements to opportunistic pathogens. Little is known about the NP antibiotic resistome. This study longitudinally investigated the composition of the NP antibiotic resistome in Streptococcus-enriched samples in a South African birth cohort.