Publications

03-Jun-2020

Wesevich A, Sutton G, Ruffin F, Park LP, Fouts D, Fowler VG, Thaden JT

Newly-named Klebsiella aerogenes (formerly Enterobacter aerogenes) is Associated with Poor Clinical Outcomes Relative to other Enterobacter Species in Patients with Bloodstream Infection.

Journal of clinical microbiology. 2020-06-03;

was recently renamed This study aimed to identify differences in clinical characteristics, outcomes, and bacterial genetics among patients with versus species bloodstream infections (BSI). We prospectively enrolled patients with or complex () BSI from 2002-2015. We performed whole genome sequencing (WGS) and pan-genome analysis on all bacteria. Overall, 150 patients with (46/150 [31%]) or (104/150 [69%]) BSI were enrolled. The two groups had similar baseline characteristics. Neither total in-hospital mortality (13/46 [28%] versus 22/104 [21%]; p=0.3) nor attributable in-hospital mortality (9/46 [20%] versus 13/104 [12%]; p=0.3) differed between patients with versus BSI, respectively. However, poor clinical outcome (death before discharge, recurrent BSI, and/or BSI complication) was higher for than BSI (32/46 [70%] versus 42/104 [40%]; p=0.001). In a multivariable regression model, BSI, relative to BSI, was predictive of poor clinical outcome (odds ratio 3.3; 95% confidence interval 1.4-8.1; p=0.008). Pan-genome analysis revealed 983 genes in 323 genomic islands unique to isolates, including putative virulence genes involved in iron acquisition (n=67), fimbriae/pili/flagella production (n=117), and metal homeostasis (n=34). Antibiotic resistance was largely found in Ecc lineage 1, which had a higher rate of multidrug resistant phenotype (23/54 [43%]) relative to all other bacterial isolates (23/96 [24%]; p=0.03). BSI was associated with poor clinical outcomes relative to BSI. Putative virulence factors in may account for these differences.

PMID: 32493786