Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.

Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.

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Authors: Wright MS, Perez F, Brinkac L, Jacobs MR, Kaye K, Cober E, van Duin D, Marshall SH, Hujer AM, Rudin SD, Hujer KM, Bonomo RA, Adams MD
Title: Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.
Citation: Antimicrobial agents and chemotherapy. 2014-08-01; 58.8: 4961-5.
Abstract:
Genome sequencing of carbapenem-resistant Klebsiella pneumoniae isolates from regional U.S. hospitals was used to characterize strain diversity and the bla(KPC) genetic context. A phylogeny based on core single-nucleotide variants (SNVs) supports a division of sequence type 258 (ST258) into two distinct groups. The primary differences between the groups are in the capsular polysaccharide locus (cps) and their plasmid contents. A strict association between clade and KPC variant was found. The bla(KPC) gene was found on variants of two plasmid backbones. This study indicates that highly similar K. pneumoniae subpopulations coexist within the same hospitals over time.
PMID: 24913165