BMC immunology. 2021-06-16; 22.1: 37.

Transcriptomics of type 2 diabetic and healthy human neutrophils

Kleinstein SE, McCorrison J, Ahmed A, Hasturk H, Van Dyke TE, Freire M

PMID: 34134627


Chronic inflammatory diseases, including diabetes and cardiovascular disease, are heterogeneous and often co-morbid, with increasing global prevalence. Uncontrolled type 2 diabetes (T2D) can result in severe inflammatory complications. As neutrophils are essential to normal and aberrant inflammation, we conducted RNA-seq transcriptomic analyses to investigate the association between neutrophil gene expression and T2D phenotype. As specialized pro-resolving lipid mediators (SPM) act to resolve inflammation, we further surveyed the impact of neutrophil receptor binding SPM resolvin E1 (RvE1) on isolated diabetic and healthy neutrophils.