Burkholderia Genome Sequencing and Analysis
We developed some of the earliest annotated genome sequences for the genus Burkholderia including the biothreat agents Burkholderia mallei and Burkholderia pseudomallei. We expanded on our genome sequencing efforts to include efforts in whole genome gene expression analysis and functional analysis of genome variation. We also sequenced several members of the Burkholderia cenocepacia complex that are important pathogens in the lungs of cystic fibrosis patients.
Publications
Frontiers in microbiology. 2015-01-01; 6.1338.
The In vitro Antibiotic Tolerant Persister Population in Burkholderia pseudomallei is Altered by Environmental Factors
PLoS genetics. 2014-09-01; 10.9: e1004640.
The tandem repeats enabling reversible switching between the two phases of β-lactamase substrate spectrum
Genome announcements. 2013-11-07; 1.6:
Sequence Determination of Burkholderia pseudomallei Strain NCTC 13392 Colony Morphology Variants
Genome announcements. 2013-10-17; 1.5:
Draft Genome Sequences of Burkholderia cenocepacia ET12 Lineage Strains K56-2 and BC7
Journal of bacteriology. 2012-11-01; 194.22: 6356-7.
Draft genome sequence determination for cystic fibrosis and chronic granulomatous disease Burkholderia multivorans isolates
PloS one. 2012-05-22; 7.5: e37585.
Twelve positions in a β-lactamase that can expand its substrate spectrum with a single amino acid substitution
Molecules and cells. 2009-02-28; 27.2: 237-41.
Simple sequence repeat (SSR)-based gene diversity in Burkholderia pseudomallei and Burkholderia mallei
BMC genomics. 2008-11-27; 9.566.
Genomic islands from five strains of Burkholderia pseudomallei
PloS one. 2008-04-30; 3.4: e2058.
Characterization of clinically-attenuated Burkholderia mallei by whole genome sequencing: candidate strain for exclusion from Select Agent lists
Funding
Funding for this project provided through the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIAID).