Burkholderia Genome Sequencing and Analysis
We developed some of the earliest annotated genome sequences for the genus Burkholderia including the biothreat agents Burkholderia mallei and Burkholderia pseudomallei. We expanded on our genome sequencing efforts to include efforts in whole genome gene expression analysis and functional analysis of genome variation. We also sequenced several members of the Burkholderia cenocepacia complex that are important pathogens in the lungs of cystic fibrosis patients.
The In vitro Antibiotic Tolerant Persister Population in Burkholderia pseudomallei is Altered by Environmental Factors.
Frontiers in microbiology. 2015-01-01; 6.1338.
The tandem repeats enabling reversible switching between the two phases of β-lactamase substrate spectrum.
PLoS genetics. 2014-09-01; 10.9: e1004640.
Sequence Determination of Burkholderia pseudomallei Strain NCTC 13392 Colony Morphology Variants.
Genome announcements. 2013-11-07; 1.6:
Draft Genome Sequences of Burkholderia cenocepacia ET12 Lineage Strains K56-2 and BC7.
Genome announcements. 2013-10-17; 1.5:
Draft genome sequence determination for cystic fibrosis and chronic granulomatous disease Burkholderia multivorans isolates.
Journal of bacteriology. 2012-11-01; 194.22: 6356-7.
Twelve positions in a β-lactamase that can expand its substrate spectrum with a single amino acid substitution.
PloS one. 2012-01-01; 7.3: e37585.
Simple sequence repeat (SSR)-based gene diversity in Burkholderia pseudomallei and Burkholderia mallei.
Molecules and cells. 2009-02-28; 27.2: 237-41.
Genomic islands from five strains of Burkholderia pseudomallei.
BMC genomics. 2008-11-27; 9.566.
Characterization of clinically-attenuated Burkholderia mallei by whole genome sequencing: candidate strain for exclusion from Select Agent lists.
PloS one. 2008-04-30; 3.4: e2058.
Funding for this project provided through the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIAID).